Results 81 to 90 of about 141,257 (371)

Asymmetrically Modified Nucleosomes [PDF]

Cell, 2012
Mononucleosomes, the basic building blocks of chromatin, contain two copies of each core histone. The associated posttranslational modifications regulate essential chromatin-dependent processes, yet whether each histone copy is identically modified in vivo is unclear.
Benjamin A. Garcia, Danny Reinberg, David B. Beck, Barry M. Zee, Nicolas L. Young, William J. Drury, Jinsook Son, Gary LeRoy, Philipp Voigt   +8 more
openaire   +3 more sources

Statistical-mechanical lattice models for protein-DNA binding in chromatin [PDF]

, 2010
Statistical-mechanical lattice models for protein-DNA binding are well established as a method to describe complex ligand binding equilibriums measured in vitro with purified DNA and protein components. Recently, a new field of applications has opened up
Adams C C, Akhrem A A, Bash R C, Gurskii G V, Gurskii G V, Hill T L, Iovanovich B, Karsten Rippe, Lando D Y, Lando D Y, Längst G, Markov A A, Mirny L A, Nechipurenko Y D, Nechipurenko Y D, Nechipurenko Y D, Poland D, Schellman J A, Svaren J, Teif V B, Teif V B, Teif V B, van Holde K E, Vladimir B Teif, Zasedatelev A S   +24 more
core   +2 more sources

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

Biochemical characterization of the placeholder nucleosome for DNA hypomethylation maintenance

Biochemistry and Biophysics Reports, 2019
DNA methylation functions as a prominent epigenetic mark, and its patterns are transmitted to the genomes of offspring. The nucleosome containing the histone H2A.Z variant and histone H3K4 mono-methylation acts as a “placeholder” nucleosome for DNA ...
Rina Hirano, Tomoya Kujirai, Lumi Negishi, Hitoshi Kurumizaka   +3 more
doaj  

Organization of fast and slow chromatin revealed by single-nucleosome dynamics [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Recent live cell imaging has revealed that chromatin is not a static, rigid structure but is dynamically fluctuating in cells. We study chromatin motion by using single-nucleosome tracking data in living human cells.
S. Ashwin, T. Nozaki, K. Maeshima, M. Sasai   +3 more
semanticscholar   +1 more source

Statistical mechanics of nucleosome ordering by chromatin structure-induced two-body interactions

, 2011
One-dimensional arrays of nucleosomes (DNA-bound histone octamers separated by stretches of linker DNA) fold into higher-order chromatin structures which ultimately make up eukaryotic chromosomes.
Chereji, Răzvan V., Locke, George, Morozov, Alexandre V., Tolkunov, Denis   +3 more
core   +1 more source

Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase

Advanced Science, EarlyView.
Fusing the VP16 domain to OCT4 and SOX2 (OvSvK) enhances iPSC generation by activating downstream targets, including those regulating the cell cycle. This accelerates reprogramming by shortening the G1 phase and reducing H3K27me3 levels. Modulating Ccnd1, Cdkn2a, and Ccne1 improves efficiency, linking cell cycle to epigenetic remodeling.
Lin Guo, Jiechun Lin, Qiwen Ren, Hao Sun, Yanhua Wu, Haofei Ge, Xiaolan Wu, Lihui Lin, Lining Liang, Changpeng Li, He Liu, Yuangbang Mai, Shilong Chu, Jiadong Liu, Jing Liu, Jiekai Chen, Duanqing Pei, Hui Zheng   +17 more
wiley   +1 more source

The interaction landscape between transcription factors and the nucleosome

Nature, 2017
Nucleosomes cover most of the genome and are thought to be displaced by transcription factors in regions that direct gene expression. However, the modes of interaction between transcription factors and nucleosomal DNA remain largely unknown.
F. Zhu, L. Farnung, Eevi Kaasinen, Biswajyoti Sahu, Yimeng Yin, Bei Wei, S. Dodonova, K. Nitta, E. Morgunova, Minna Taipale, P. Cramer, J. Taipale   +11 more
semanticscholar   +1 more source

Determinants of nucleosome positioning [PDF]

Nature Structural & Molecular Biology, 2013
Nucleosome positioning is critical for gene expression and most DNA-related processes. Here we review the dominant patterns of nucleosome positioning that have been observed and summarize the current understanding of their underlying determinants. The genome-wide pattern of nucleosome positioning is determined by the combination of DNA sequence, ATP ...
Kevin Struhl, Eran Segal
openaire   +3 more sources

ISWI catalyzes nucleosome sliding in condensed nucleosome arrays

Nature Structural & Molecular Biology, 2023
SummaryHow chromatin enzymes work in condensed chromatin and how they maintain diffusional mobility inside remains unexplored. We investigated these challenges using theDrosophilaISWI remodeling ATPase, which slides nucleosomes along DNA. Folding of chromatin fibers did not affect slidingin vitro. Catalytic rates were also comparable in- and outside of
Petra Vizjak, Dieter Kamp, Nicola Hepp, Alessandro Scacchetti, Mariano Gonzalez Pisfil, Joseph Bartho, Mario Halic, Peter B. Becker, Michaela Smolle, Johannes Stigler, Felix Mueller-Planitz   +10 more
openaire   +3 more sources