Results 1 to 10 of about 72,215 (324)

Circulating Nucleosomes and Histones in the Development of Lung Injury and Sepsis [PDF]

Current Issues in Molecular Biology
Cellular nucleosomes—the structural and functional units of chromatin—are inherently present in cells. During cellular damage or cell death, nucleosomes are released into circulation, either actively or passively.
Saugata Dutta, Sauradeep Dutta, Payaningal R. Somanath, S. Priya Narayanan, Xiaoyun Wang, Duo Zhang   +5 more
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Breaking the aging epigenetic barrier

Frontiers in Cell and Developmental Biology, 2022
Aging is an inexorable event occurring universally for all organisms characterized by the progressive loss of cell function. However, less is known about the key events occurring inside the nucleus in the process of aging.
Sweta Sikder, Ganesan Arunkumar, Daniël P. Melters, Yamini Dalal   +3 more
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The TFIIH complex is required to establish and maintain mitotic chromosome structure

eLife, 2022
Condensins compact chromosomes to promote their equal segregation during mitosis, but the mechanism of condensin engagement with and action on chromatin is incompletely understood.
Julian Haase, Richard Chen, Wesley M Parker, Mary Kate Bonner, Lisa M Jenkins, Alexander E Kelly   +5 more
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Histone Modifications, Internucleosome Dynamics, and DNA Stresses: How They Cooperate to “Functionalize” Nucleosomes

Frontiers in Genetics, 2022
Tight packaging of DNA in chromatin severely constrains DNA accessibility and dynamics. In contrast, nucleosomes in active chromatin state are highly flexible, can exchange their histones, and are virtually “transparent” to RNA polymerases, which ...
Wladyslaw A. Krajewski
doaj   +1 more source

Proximal-end bias from in-vitro reconstituted nucleosomes and the result on downstream data analysis.

PLoS ONE, 2021
The most basic level of eukaryotic gene regulation is the presence or absence of nucleosomes on DNA regulatory elements. In an effort to elucidate in vivo nucleosome patterns, in vitro studies are frequently used.
David A Bates, Charles E Bates, Andrew S Earl, Colin Skousen, Ashley N Fetbrandt, Jordon Ritchie, Paul M Bodily, Steven M Johnson   +7 more
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An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability

eLife, 2023
In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to impact histone N-termini availability to the epigenetic machinery. Notably, H3 tail acetylation (
Kanishk Jain, Matthew R Marunde, Jonathan M Burg, Susan L Gloor, Faith M Joseph, Karl F Poncha, Zachary B Gillespie, Keli L Rodriguez, Irina K Popova, Nathan W Hall, Anup Vaidya, Sarah A Howard, Hailey F Taylor, Laylo Mukhsinova, Ugochi C Onuoha, Emily F Patteson, Spencer W Cooke, Bethany C Taylor, Ellen N Weinzapfel, Marcus A Cheek, Matthew J Meiners, Geoffrey C Fox, Kevin EW Namitz, Martis W Cowles, Krzysztof Krajewski, Zu-Wen Sun, Michael S Cosgrove, Nicolas L Young, Michael-Christopher Keogh, Brian D Strahl   +29 more
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A species-specific nucleosomal signature defines a periodic distribution of amino acids in proteins [PDF]

Open Biology, 2015
Nucleosomes are the basic structural units of chromatin. Most of the yeast genome is organized in a pattern of positioned nucleosomes that is stably maintained under a wide range of physiological conditions.
Luis Quintales, Ignacio Soriano, Enrique Vázquez, Mónica Segurado, Francisco Antequera   +4 more
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Dominant effects of the histone mutant H3-L61R on Spt16-gene interactions in budding yeast

Epigenetics, 2022
Recent studies have unveiled an association between an L61R substitution within the human histone H3.3 protein and the presentation of neurodevelopmental disorders in two patients.
Alex Pablo-Kaiser, McKenzie G. Tucker, Grace A. Turner, Elijah G. Dilday, Avery G. Olmstead, Caroline L. Tackett, Andrea A. Duina   +6 more
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Cellular uptake of extracellular nucleosomes induces innate immune responses by binding and activating cGMP-AMP synthase (cGAS)

Scientific Reports, 2020
The nucleosome is the basic structural repeating unit of chromatin. DNA damage and cell apoptosis release nucleosomes into the blood circulatory system, and increased levels of circulating nucleosomes have been observed to be related to inflammation and ...
Huawei Wang, Chuanlong Zang, Mengtian Ren, Mengdi Shang, Zhenghua Wang, Xuemei Peng, Qiangzhe Zhang, Xin Wen, Zhen Xi, Chuanzheng Zhou   +9 more
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The esBAF and ISWI nucleosome remodeling complexes influence occupancy of overlapping dinucleosomes and fragile nucleosomes in murine embryonic stem cells

BMC Genomics, 2023
Background Nucleosome remodeling factors regulate the occupancy and positioning of nucleosomes genome-wide through ATP-driven DNA translocation. While many nucleosomes are consistently well-positioned, some nucleosomes and alternative nucleosome ...
David C. Klein, Kris Troy, Sarah A. Tripplehorn, Sarah J. Hainer   +3 more
doaj   +1 more source