Results 1 to 10 of about 71,049 (222)

Breaking the aging epigenetic barrier

Frontiers in Cell and Developmental Biology, 2022
Aging is an inexorable event occurring universally for all organisms characterized by the progressive loss of cell function. However, less is known about the key events occurring inside the nucleus in the process of aging.
Sweta Sikder, Ganesan Arunkumar, Daniël P. Melters, Yamini Dalal   +3 more
doaj   +1 more source

An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability

eLife, 2023
In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to impact histone N-termini availability to the epigenetic machinery. Notably, H3 tail acetylation (
Kanishk Jain, Matthew R Marunde, Jonathan M Burg, Susan L Gloor, Faith M Joseph, Karl F Poncha, Zachary B Gillespie, Keli L Rodriguez, Irina K Popova, Nathan W Hall, Anup Vaidya, Sarah A Howard, Hailey F Taylor, Laylo Mukhsinova, Ugochi C Onuoha, Emily F Patteson, Spencer W Cooke, Bethany C Taylor, Ellen N Weinzapfel, Marcus A Cheek, Matthew J Meiners, Geoffrey C Fox, Kevin EW Namitz, Martis W Cowles, Krzysztof Krajewski, Zu-Wen Sun, Michael S Cosgrove, Nicolas L Young, Michael-Christopher Keogh, Brian D Strahl   +29 more
doaj   +1 more source

The TFIIH complex is required to establish and maintain mitotic chromosome structure

eLife, 2022
Condensins compact chromosomes to promote their equal segregation during mitosis, but the mechanism of condensin engagement with and action on chromatin is incompletely understood.
Julian Haase, Richard Chen, Wesley M Parker, Mary Kate Bonner, Lisa M Jenkins, Alexander E Kelly   +5 more
doaj   +1 more source

A species-specific nucleosomal signature defines a periodic distribution of amino acids in proteins [PDF]

Open Biology, 2015
Nucleosomes are the basic structural units of chromatin. Most of the yeast genome is organized in a pattern of positioned nucleosomes that is stably maintained under a wide range of physiological conditions.
Luis Quintales, Ignacio Soriano, Enrique Vázquez, Mónica Segurado, Francisco Antequera   +4 more
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Histone Modifications, Internucleosome Dynamics, and DNA Stresses: How They Cooperate to “Functionalize” Nucleosomes

Frontiers in Genetics, 2022
Tight packaging of DNA in chromatin severely constrains DNA accessibility and dynamics. In contrast, nucleosomes in active chromatin state are highly flexible, can exchange their histones, and are virtually “transparent” to RNA polymerases, which ...
Wladyslaw A. Krajewski
doaj   +1 more source

Dominant effects of the histone mutant H3-L61R on Spt16-gene interactions in budding yeast

Epigenetics, 2022
Recent studies have unveiled an association between an L61R substitution within the human histone H3.3 protein and the presentation of neurodevelopmental disorders in two patients.
Alex Pablo-Kaiser, McKenzie G. Tucker, Grace A. Turner, Elijah G. Dilday, Avery G. Olmstead, Caroline L. Tackett, Andrea A. Duina   +6 more
doaj   +1 more source

Cellular uptake of extracellular nucleosomes induces innate immune responses by binding and activating cGMP-AMP synthase (cGAS)

Scientific Reports, 2020
The nucleosome is the basic structural repeating unit of chromatin. DNA damage and cell apoptosis release nucleosomes into the blood circulatory system, and increased levels of circulating nucleosomes have been observed to be related to inflammation and ...
Huawei Wang, Chuanlong Zang, Mengtian Ren, Mengdi Shang, Zhenghua Wang, Xuemei Peng, Qiangzhe Zhang, Xin Wen, Zhen Xi, Chuanzheng Zhou   +9 more
doaj   +1 more source

Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation

eLife, 2021
In meiosis, DNA double-strand break (DSB) formation by Spo11 initiates recombination and enables chromosome segregation. Numerous factors are required for Spo11 activity, and couple the DSB machinery to the development of a meiosis-specific ‘axis ...
Dorota Rousová, Vaishnavi Nivsarkar, Veronika Altmannova, Vivek B Raina, Saskia K Funk, David Liedtke, Petra Janning, Franziska Müller, Heidi Reichle, Gerben Vader, John R Weir   +10 more
doaj   +1 more source

Epichromatin and chromomeres: a ‘fuzzy’ perspective [PDF]

Open Biology, 2018
‘Epichromatin’, the surface of chromatin beneath the interphase nuclear envelope (NE) or at the surface of mitotic chromosomes, was discovered by immunostaining with a specific bivalent mouse monoclonal anti-nucleosome antibody (mAb PL2-6). ‘Chromomeres’,
Donald E. Olins, Ada L. Olins
doaj   +1 more source

The Role of Histone Variants in the Epithelial-To-Mesenchymal Transition

Cells, 2020
The epithelial-to-mesenchymal transition (EMT) is a physiological process activated during early embryogenesis, which continues to shape tissues and organs later on. It is also hijacked by tumor cells during metastasis. The regulation of EMT has been the
Imtiaz Nisar Lone, Burcu Sengez, Ali Hamiche, Stefan Dimitrov, Hani Alotaibi   +4 more
doaj   +1 more source