Results 111 to 120 of about 74,179 (293)

Phase separation directs ubiquitination of gene-body nucleosomes

Nature, 2020
Laura D. Gallego, Maren Schneider, Chitvan Mittal, Anete Romanauska, Ricardo M. Gudino Carrillo, Tobias Schubert, B. F. Pugh, A. Köhler   +7 more
semanticscholar   +1 more source

Circular RNAs: Epigenetic Puppeteers Pulling the Strings of Cancer Pathogenesis

Medicine Bulletin, EarlyView.
ABSTRACT Circular RNAs (circRNAs), a unique class of endogenous noncoding RNAs characterized by their covalently closed loop structure, have emerged as pivotal players in cancer biology due to their exceptional stability, tissue‐specific expression, and diverse regulatory functions.
Yimao Wu, Zichang Chen, Junying Lee, Gokhan Zengin, Meng‐Yao Li   +4 more
wiley   +1 more source

Nonhistone Scm3 and Histones CenH3-H4 Assemble the Core of Centromere-Specific Nucleosomes [PDF]

, 2007
Gaku Mizuguchi, Hua Xiao, Jan Wiśniewski, M. Mitchell Smith, Carl Wu   +4 more
openalex   +1 more source

A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome.

Genome Research, 2008
Most nucleosomes are well-organized at the 5' ends of S. cerevisiae genes where "-1" and "+1" nucleosomes bracket a nucleosome-free promoter region (NFR). How nucleosomal organization is specified by the genome is less clear.
Travis N. Mavrich, I. Ioshikhes, Bryan J. Venters, Cizhong Jiang, L. Tomsho, J. Qi, S. Schuster, I. Albert, B. Pugh   +8 more
semanticscholar   +1 more source

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, EarlyView.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Tissue plasminogen activator modified thromboelastography identifies fibrinolysis resistance in dogs with immune-mediated hemolytic anemia

Frontiers in Veterinary Science
IntroductionImmune-mediated hemolytic anemia (IMHA) is an important immunologic disorder in dogs that is associated with high mortality rates, frequently due to thromboembolism.
Robert Goggs, Robert Goggs, Samantha Davis, Marjory B. Brooks   +3 more
doaj   +1 more source

Histone Tail Dynamics in Partially Disassembled Nucleosomes During Chromatin Remodeling

Frontiers in Molecular Biosciences, 2019
Nucleosomes are structural units of the chromosome consisting of DNA wrapped around histone proteins, and play important roles in compaction and regulation of the chromatin structure.
Takeru Kameda, Akinori Awazu, Akinori Awazu, Yuichi Togashi, Yuichi Togashi, Yuichi Togashi   +5 more
doaj   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

Whole genome regulatory effect of MoISW2 and consequences for the evolution of the rice plant pathogenic fungus Magnaporthe oryzae

mBio
Isw2 proteins, ubiquitous across eukaryotes, exhibit a propensity for DNA binding and exert dynamic influences on local chromosome condensation in an ATP-dependent fashion, thereby modulating the accessibility of neighboring genes to transcriptional ...
Mengtian Pei, Yakubu Saddeeq Abubakar, Hina Ali, Lianyu Lin, Xianying Dou, Guodong Lu, Zonghua Wang, Stefan Olsson, Ya Li   +8 more
doaj   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source