Results 121 to 130 of about 69,179 (216)

Effects of the Missense Variants on Complete Phenotype and Splicing Variant on Severe Growth Retardation in the BPTF Gene

Developmental Neurobiology, Volume 85, Issue 3, July 2025.
ABSTRACT Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies (NEDDFL, OMIM no #617755) is an ultra‐rare syndrome associated with heterozygous pathogenic variants in the BPTF gene. Haploinsufficiency of the BPTF gene, a chromatin remodeling gene that is related to epigenetic modification, is the cause of this disease.
Gül Ünsel‐Bolat, Hamide Betul Gerik‐Celebi, Betül Diler Durgut, Ayberk Türkyılmaz, Hilmi Bolat   +4 more
wiley   +1 more source

Sunflower seed‐specific HSFA9 induces persistent chromatin accessibility during seed‐to‐seedling developmental transition [PDF]

Plant J
SUMMARY HSFA9 (A9) is a seed‐specific transcription factor that contributes to seed longevity in sunflower. A9 also links the regulation of seed maturation with that of early seedling greening through its effects on various light receptors. Transcriptomic analyses of transgenic tobacco seeds suggested that A9 might affect chromatin remodeling.
Prieto‐Dapena P, Carranco R, Almoguera C, Jordano J.   +3 more
europepmc   +2 more sources

Double the Double: Revisiting BCL11B's Multimerization

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 7, Page 1205-1211, July 2025.
ABSTRACT The transcription factor B Cell Lymphoma/Leukemia 11B (BCL11B) exerts a bi‐directional function in cancer, with its role as an emerging therapeutic target in cancer treatment being particularly intriguing. BCL11B knockouts in cultured T cells revealed the acquisition of properties characteristic of natural killer cells, hinting at its ...
Anne Susemihl, Norman Geist, Piotr Grabarczyk, Christian A. Schmidt, Mihaela Delcea, Lukas Schulig   +5 more
wiley   +1 more source

Gene promoters are genomically encoded to facilitate histone exchange/incorporation. [PDF]

PLoS Biol
Bartholomew B.
europepmc   +1 more source

H2A.Z deposition by the SWR complex is stimulated by polyadenine DNA sequences in nucleosomes. [PDF]

PLoS Biol
Converso C, Pierrakeas L, Chan L, Chowdhury S, de Onis E, Kuznetsov VI, Denu JM, Luk E.   +7 more
europepmc   +1 more source

Nucleosome Structure [PDF]

Science, 1986
openaire   +2 more sources

Cryo-EM Structures of Native Chromatin Units From Human Cells. [PDF]

Genes Cells
Hatazawa S, Fukuda Y, Kobayashi Y, Negishi L, Kikkawa M, Takizawa Y, Kurumizaka H.   +6 more
europepmc   +1 more source

Chemical Switching: A Concept Inspired by Strategies from Biocatalysis and Organocatalysis

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
Chemical Switching is introduced as a novel technology that exploits the promiscuity of enzymatic transformations by applying small molecule organocatalytic switches (ORCAs) or gain‐of‐function protein variants. The modulation of underlying chemical principles thereby amplifies low‐rate or installs otherwise absent enzymatic activities to dominate ...
Torkild Visnes, Kaixin Zhou, Aurino M. Kemas, Dominic Campopiano, Volker M. Lauschke, Maurice Michel   +5 more
wiley   +1 more source

Quantitative spatial analysis of chromatin biomolecular condensates using cryoelectron tomography. [PDF]

Proc Natl Acad Sci U S A
Zhou H, Hutchings J, Shiozaki M, Zhao X, Doolittle LK, Yang S, Yan R, Jean N, Riggi M, Yu Z, Villa E, Rosen MK.   +11 more
europepmc   +1 more source

Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes. [PDF]

Biochemistry
Delvaux de Fenffe CM, Govers J, Mattiroli F.   +2 more
europepmc   +1 more source