Results 141 to 150 of about 69,179 (216)

The WAC-downWAC domain in the yeast ISW2 nucleosome remodeling complex forms a structural module essential for ISW2 function but not cell viability. [PDF]

Epigenetics Chromatin
Singh AK, Grünert SI, Pfaller L, Mueller-Planitz F.   +3 more
europepmc   +1 more source

Is Enhancer Function Driven by Protein–Protein Interactions? From Bacteria to Leukemia

BioEssays, Volume 47, Issue 6, June 2025.
Enhancers are key regulatory elements that are conceptually conserved from bacteria to humans. Enhancer dysregulation is common in cancers, including leukemia. We argue that highly specific protein–protein interactions, including transcription factors, mediate enhancer‐promoter proximity to allow enhancer‐bound factors to directly act on RNA polymerase
Nicholas T. Crump, Thomas A. Milne
wiley   +1 more source

Histone tetrasome dynamics affects chromatin transcription. [PDF]

Nucleic Acids Res
Shi X, Fedulova AS, Kotova EY, Maluchenko NV, Armeev GA, Chen Q, Prasanna C, Sivkina AL, Feofanov AV, Kirpichnikov MP, Nordensköld L, Shaytan AK, Studitsky VM.   +12 more
europepmc   +1 more source

A snapshot of the role of estrogen‐regulated divergent non‐coding transcripts

Clinical and Translational Discovery, Volume 5, Issue 3, June 2025.
The expansion of genome‐wide studies has identified widespread transcription that may result in previously unstudied transcripts, such as divergent long non‐coding RNAs. Abstract Recent high‐throughput sequencing technologies have discovered various polymerase II transcribed transcripts.
Barbara Yang, Melina J. Sedano, Kimberly Diwa, Johnathan Dominguez, Gabriela Boisselier, Alana L. Harrison, Victoria A. Reid, Enrique I. Ramos, Maria V. Jimenez, Laura A. Sanchez‐Michael, Shreya Kolli, Jai Patel, Debra Lee, Mahalakshmi Vijayaraghavan, Jessica Chacon, Subramanian Dhandayuthapani, Shrikanth S. Gadad   +16 more
wiley   +1 more source

Plasma H3.1 nucleosomes as biomarkers of infection, inflammation and organ failure. [PDF]

Crit Care
Filippini DFL, Jiang M, Kramer L, van der Poll T, Cremer O, Hla TTW, Retter A, Bos LDJ, MARS consortium.   +8 more
europepmc   +1 more source

Antisenescence therapies for age‐related bone loss: Target factors, medicines, biomedical materials

Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.
With extended lifespans causing population aging, bone aging has become a worldwide issue. Cellular senescence in the bone microenvironment causes bone degeneration and dysfunction. This review summarises targets in cellular senescence and bone aging while detailing potential therapeutic strategies, including novel medicines and innovative biomedical ...
Qiyue Zhu, Menglong Hu, Likun Wu, Erfan Wei, Xingtong Pan, Hao Liu, Yunsong Liu   +6 more
wiley   +1 more source

Regulation of Genome Architecture in Huntington's Disease. [PDF]

Biochemistry
Portillo-Ledesma S, Hang M, Schlick T.
europepmc   +1 more source

Halymenia durvillei Extracts Exert Antiobesity Effects by Targeting hosl‐1‐Mediated Lipolysis in a Glucose‐Induced Caenorhabditis elegans Model

eFood, Volume 6, Issue 3, June 2025.
This study demonstrates the antiobesity potential of Halymenia durvillei (H. durvillei) extracts using a Caenorhabditis elegans (C. elegans) obesity model. The extracts significantly reduced total fat accumulation, lowered reactive oxygen species (ROS) levels, and extended the lifespan in glucose‐fed C. elegans. These beneficial effects may be mediated
Kawita Chumphoochai, Sukrit Promtang, Pawanrat Chalorak, Preeyanuch Manohong, Nakorn Niamnont, Montakan Tamtin, Prasert Sobhon, Simon Tuck, Krai Meemon   +8 more
wiley   +1 more source

MagIC-Cryo-EM, structural determination on magnetic beads for scarce macromolecules in heterogeneous samples. [PDF]

Elife
Arimura Y, Konishi HA, Funabiki H.
europepmc   +1 more source

The INO80 Chromatin Remodeling Complex Regulates Histone H2A.Z Mobility and the G1‐S Transition in Oligodendrocyte Precursors

Glia, Volume 73, Issue 6, Page 1307-1323, June 2025.
Main Points Inactivating the INO80 chromatin remodelling complex greatly extends the oligodendrocyte precursor (OP) cell cycle by prolonging G1. INO80 acts in OPs via histone H2A/H2A.Z exchange. INO80 binds the transcriptional regulator OLIG2 in OPs.
Jordan L. Wright, Yi Jiang, Stuart G. Nayar, Huiliang Li, William D. Richardson   +4 more
wiley   +1 more source