Results 151 to 160 of about 74,179 (293)
International Journal of Cancer, Volume 158, Issue 5, Page 1336-1347, 1 March 2026.What's New? Small cell lung cancer (SCLC) is aggressive and difficult to treat but exhibits high levels of stathmin 1 (STMN1), a candidate therapeutic target. In this study, the authors synthesized a chlorambucil (Chb)‐conjugated pyrrole–imidazole polyamide (PIP) compound targeting the STMN1 promoter and DNA sequences and evaluated its efficacy in ...
Ryohei Yoshikawa +23 more
wiley +1 more source
Nucleosome core particles can be reconstituted using mixtures of histones from two eukaryotic kingdoms [PDF]
, 1979 M.L. Wilhelm +3 more
openalex +1 more source
Molecular polymorphisms that underlie trait variation in crops: Lessons learned from soybean
The Plant Genome, Volume 19, Issue 1, March 2026.Abstract Genetic variation within a germplasm is important in crop improvement, providing a foundation for breeders to develop new varieties. Traits of agronomic and economic importance are often mapped to identify the genetic basis of observed phenotypes, oftentimes using quantitative trait locus (QTL) analysis.
Mary Jane C. Espina +2 more
wiley +1 more source
International Journal of Cancer, Volume 158, Issue 4, Page 1116-1125, 15 February 2026.What's new? Cervical cancer screening is challenging in postmenopausal women, partly due to physiological changes that reduce the sensitivity of cytology and colposcopy. This study evaluated the diagnostic performance of combined PAX1 and JAM3 gene methylation testing in a large cohort of postmenopausal women undergoing colposcopy. Compared to cytology
Huanzi Peng +11 more
wiley +1 more source
American Journal of Medical Genetics Part A, Volume 200, Issue 2, Page 348-352, February 2026.ABSTRACT Genome‐wide non‐invasive prenatal testing (NIPT) is a powerful tool for prenatal detection of the common aneuploidies causing Down‐, Edwards‐, and Patau syndrome. Its genome‐wide reach also enables the detection of unbalanced structural chromosomal abnormalities.
Servi J. C. Stevens +9 more
wiley +1 more source
Chromatin Fibers Are Formed by Heterogeneous Groups of Nucleosomes In Vivo
Cell, 2015 M. A. Ricci +4 more
semanticscholar +1 more source
Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling
Brain and Behavior, Volume 16, Issue 2, February 2026.Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu +1 more
wiley +1 more source
ISWI proteins participate in the genome‐wide nucleosome distribution in Arabidopsis [PDF]
, 2014 Guang Li +6 more
openalex +1 more source
Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.SpliCOOL‐seq achieves high‐throughput single‐cell co‐profiling of DNA methylation and chromatin accessibility. DNMT inhibitors caused cancer cell demethylation with divergent patterns. SpliCOOL‐seq enables the discovery of genes related to LUAD tumorigenesis. Ageing and LUAD tumorigenesis may share similar epigenetic alterations.
Qingmei Shen +6 more
wiley +1 more source