DNTTIP1 drives leukaemogenesis through MiDAC‐mediated epigenetic silencing of BMF
Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.DNTTIP1 cooperates with SP1 to recruit HDAC1/2, leading to BMF silencing and reduced competitive binding of BMF to BCL2.This suppresses autophagy and apoptosis, promoting leukaemic cell survival. Targeting the DNTTIP1‐HDAC1/2‐BMF axis reactivates BMF and induces anti‐leukaemic effects.
Ruolin Xiu +12 more
wiley +1 more source
ChIP-seq of plasma cell-free nucleosomes identifies cell-of-origin gene expression programs
, 2020 Nir Friedman +3 more
openalex +1 more source
International Journal of Cancer, Volume 158, Issue 3, Page 511-526, 1 February 2026.Abstract Viral infections play a significant role in cancer development, making detecting viral signatures a promising approach for early cancer diagnosis. Circulating free DNA (cfDNA), released into the bloodstream by tumors and other cells, has emerged as a powerful biomarker for non‐invasive cancer screening.
Richard Donkor Amponsah +4 more
wiley +1 more source
In vivo assembly of complete eukaryotic nucleosomes and (H3-H4)-only non-canonical nucleosomal particles in the model bacterium Escherichia coli [PDF]
Xiaojuan Zhou +9 more
openalex +1 more source
Diagnostic and Prognostic Value of cfDNA Concentration and Fragmentation in Prostate Cancer
The Prostate, Volume 86, Issue 3, Page 338-348, February 15, 2026.ABSTRACT Objective To evaluate the value of circulating free DNA (cfDNA) in prostate cancer (PCa) by cfDNA assay and analysis of plasma and urinary cfDNA fragmentation to determine the usefulness of this parameter for risk staging and tumor progression monitoring.
Marta Victoria Lorenzo‐Sánchez +8 more
wiley +1 more source
Parasite nucleosomes: Chromatin dynamics rewired. [PDF]
PLoS PathogDeák G, Wilson MD.
europepmc +1 more source
Characterizing nucleosome dynamics from genomic and epigenetic information using rule induction learning [PDF]
, 2009 Ngoc Tu Le, Tu Bao Ho, Dang Hung Tran
openalex +1 more source
A hitchhiker's guide to single‐cell epigenomics: Methods and applications for cancer research
International Journal of Cancer, Volume 158, Issue 2, Page 291-304, 15 January 2026.Abstract Genetic mutations are well known to influence tumorigenesis, tumor progression, treatment response and relapse, but the role of epigenetic variation in cancer progression is still largely unexplored. The lack of epigenetic understanding in cancer evolution is in part due to the limited availability of methods to examine such a heterogeneous ...
Marta Moreno‐Gonzalez +2 more
wiley +1 more source
Tension-Dependent Free Energies of Nucleosome Unwrapping
, 2016 Joshua Lequieu +3 more
openalex +1 more source
The incorporation of the novel histone variant H2AL2 confers unusual structural and functional properties of the nucleosome [PDF]
, 2009 Sajad Hussain Syed +8 more
openalex +1 more source