Results 181 to 190 of about 104,131 (352)
We report on the clinical characteristics of three new patients with pathogenic TRRAP variants expanding the syndrome's phenotype. In order to investigate the TRRAP potential involvement in skeletal development, osteoclastogenesis in Patient 1 was evaluated and TRRAP expression in osteoclasts and osteoblasts were analyzed.
Chiara Minotti+17 more
wiley +1 more source
IntroductionImmune-mediated hemolytic anemia (IMHA) is an important immunologic disorder in dogs that is associated with high mortality rates, frequently due to thromboembolism.
Robert Goggs+3 more
doaj +1 more source
Preferential in vitro assembly of nucleosome cores on some AT-rich regions of SV40 DNA [PDF]
Bohdan Wasylyk, P Oudet, Pierre Chambon
openalex +1 more source
Chromatin: a tunable spring at work inside chromosomes
This paper focuses on mechanical aspects of chromatin biological functioning. Within a basic geometric modeling of the chromatin assembly, we give for the first time the complete set of elastic constants (twist and bend persistence lengths, stretch ...
A. E. H. Love+50 more
core +1 more source
Membraneless Organelles and Phase Separation in Tumours: Mechanisms and Prospects
The Salient and Novel Findings: This article summarises the latest research advancements in phase separation within tumours, with a particular focus on the role and molecular mechanisms of liquid–liquid phase separation (LLPS) in tumour progression.
Hao Yang+3 more
wiley +1 more source
Chromatin and nucleosome structure [PDF]
Richard Mandel, Gerald D. Fasman
openalex +1 more source
The two-angle model and the phase diagram for Chromatin
We have studied the phase diagram for chromatin within the framework of the two-angle model. Rather than improving existing models with finer details our main focus of the work is getting mathematically rigorous results on the structure, especially on ...
Dieter W. Heermann+6 more
core +1 more source
Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang+4 more
wiley +1 more source
The nature of the interaction of nucleosomes with a eukaryotic RNA polymerase II [PDF]
David M.J. Lilley+2 more
openalex +1 more source
Chromatin machinery influences how DNA is ‘wrapped’ around histones in the nucleosome of immune and brain cells. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16299 Abstract We report eight children with de novo pathogenic DNA variants in chromatin‐related genes: MORC2, CHD7, KANSL1, KMT2D, ZMYND11, HIST1HIE, EP300, and KMT2B.
Russell C. Dale+14 more
wiley +1 more source