Results 11 to 20 of about 72,215 (324)
Circulating Nucleosomes and Nucleosome Modifications as Biomarkers in Cancer [PDF]
Cancers, 2017 Traditionally the stratification of many cancers involves combining tumour and clinicopathological features (e.g., patient age; tumour size, grade, receptor status and location) to inform treatment options and predict recurrence risk and survival ...
P. McAnena, James A. L. Brown, M. Kerin
semanticscholar +3 more sources
Science Advances, 2015 Reestablishment of the nucleosome landscape behind the replication fork is fundamental for epigenetic memory during development. Eukaryotic replication disrupts each nucleosome as the fork passes, followed by reassembly of disrupted nucleosomes and ...
S. Ramachandran, S. Henikoff
semanticscholar +3 more sources
Nucleosomes impede Cas9 access to DNA in vivo and in vitro
eLife, 2016 The prokaryotic CRISPR (clustered regularly interspaced palindromic repeats)-associated protein, Cas9, has been widely adopted as a tool for editing, imaging, and regulating eukaryotic genomes.
Max A Horlbeck +8 more
doaj +2 more sources
Asymmetrically Modified Nucleosomes [PDF]
Cell, 2012 Mononucleosomes, the basic building blocks of chromatin, contain two copies of each core histone. The associated posttranslational modifications regulate essential chromatin-dependent processes, yet whether each histone copy is identically modified in vivo is unclear.
P. Voigt +8 more
semanticscholar +4 more sources
Histone dynamics mediate DNA unwrapping and sliding in nucleosomes
Nature Communications, 2021 Nucleosomes are elementary building blocks of chromatin in eukaryotes. They tightly wrap ∼147 DNA base pairs around an octamer of histone proteins. How nucleosome structural dynamics affect genome functioning is not completely clear.
G. Armeev +4 more
semanticscholar +1 more source
bioRxiv, 2021 Single-molecule imaging of cell-free nucleosomes detects colorectal cancer with high accuracy and sensitivity. The analysis of cell-free DNA (cfDNA) in plasma provides information on pathological processes in the body.
Vadim Fedyuk +18 more
semanticscholar +1 more source
Physical Review Letters, 2008 We present a statistical-mechanical analysis of the positioning of nucleosomes along one of the chromosomes of yeast DNA as a function of the strength of the binding potential and of the chemical potential of the nucleosomes. We find a significant density of two-level nucleosome switching regions where, as a function of the chemical potential, the ...
David J. Schwab +3 more
openaire +4 more sources
Mechanisms of OCT4-SOX2 motif readout on nucleosomes
Science, 2020 Engaging the nucleosome Cell identity is defined by gene expression patterns that are established through the binding of specific transcription factors.
A. Michael +14 more
semanticscholar +1 more source
Structural basis for the inhibition of cGAS by nucleosomes
Science, 2020 Saving a host cell from itself A fundamental mammalian defense mechanism against pathogens and damaged cellular DNA is to recognize DNA fragments in the cytosol and trigger an inflammatory response.
T. Kujirai +8 more
semanticscholar +1 more source
A systematic analysis of nucleosome core particle and nucleosome-nucleosome stacking structure [PDF]
Scientific Reports, 2018 AbstractChromatin condensation is driven by the energetically favourable interaction between nucleosome core particles (NCPs). The close NCP-NCP contact, stacking, is a primary structural element of all condensed states of chromatin in vitro and in vivo.
Korolev, Nikolay +2 more
openaire +4 more sources