Results 11 to 20 of about 74,179 (293)
Uncovering the forces between nucleosomes using DNA origami
Science Advances, 2016 Electron microscopy with a DNA origami force spectrometer reveals the energy landscapes for nucleosome-nucleosome interactions. Revealing the energy landscape for nucleosome association may contribute to the understanding of higher-order chromatin ...
Jonas J Funke +2 more
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Pathogens, 2021 (1) Background: Hepatocellular carcinoma (HCC) is the most serious complication of chronic hepatitis B (CHB). Recently, the detection of circulating cell-free (cf) DNA and nucleosomes has found numerous applications in oncology.
Alkistis Papatheodoridi +4 more
doaj +1 more source
Single-molecule decoding of combinatorially modified nucleosomes
Science, 2016 Daniel Jones +2 more
exaly +2 more sources
bioRxiv, 2021 Single-molecule imaging of cell-free nucleosomes detects colorectal cancer with high accuracy and sensitivity. The analysis of cell-free DNA (cfDNA) in plasma provides information on pathological processes in the body.
Vadim Fedyuk +18 more
semanticscholar +1 more source
Abstract P-18: PARP1-Induced Structural Rearrangements are Enhanced in Cisplatin-Treated Nucleosomes [PDF]
International Journal of Biomedicine, 2019 Background: Cisplatin (Fig. 1) is a low molecular weight platinum-containing compound with a square planar geometry. It is widely used for the treatment of different cancers.
Natalya Maluchenko +4 more
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Fine Chromatin-Driven Mechanism of Transcription Interference by Antisense Noncoding Transcription
Cell Reports, 2020 Summary: Eukaryotic genomes are almost entirely transcribed by RNA polymerase II. Consequently, the transcription of long noncoding RNAs often overlaps with coding gene promoters, triggering potential gene repression through a poorly characterized ...
Jatinder Kaur Gill +4 more
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Breaking the aging epigenetic barrier
Frontiers in Cell and Developmental Biology, 2022 Aging is an inexorable event occurring universally for all organisms characterized by the progressive loss of cell function. However, less is known about the key events occurring inside the nucleus in the process of aging.
Sweta Sikder +3 more
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An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability
eLife, 2023 In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to impact histone N-termini availability to the epigenetic machinery. Notably, H3 tail acetylation (
Kanishk Jain +29 more
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CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere
Science, 2015 , Evan M Smoak, Tomoyasu Mani
exaly +2 more sources
Frontiers in Genetics, 2022 Tight packaging of DNA in chromatin severely constrains DNA accessibility and dynamics. In contrast, nucleosomes in active chromatin state are highly flexible, can exchange their histones, and are virtually “transparent” to RNA polymerases, which ...
Wladyslaw A. Krajewski
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