Results 11 to 20 of about 71,049 (222)
Circulating Nucleosomes and Histones in the Development of Lung Injury and Sepsis [PDF]
Current Issues in Molecular BiologyCellular nucleosomes—the structural and functional units of chromatin—are inherently present in cells. During cellular damage or cell death, nucleosomes are released into circulation, either actively or passively.
Saugata Dutta +5 more
doaj +2 more sources
Nucleosomes impede Cas9 access to DNA in vivo and in vitro
eLife, 2016 The prokaryotic CRISPR (clustered regularly interspaced palindromic repeats)-associated protein, Cas9, has been widely adopted as a tool for editing, imaging, and regulating eukaryotic genomes.
Max A Horlbeck +8 more
doaj +2 more sources
Histone dynamics mediate DNA unwrapping and sliding in nucleosomes
Nature Communications, 2021 Nucleosomes are elementary building blocks of chromatin in eukaryotes. They tightly wrap ∼147 DNA base pairs around an octamer of histone proteins. How nucleosome structural dynamics affect genome functioning is not completely clear.
G. Armeev +4 more
semanticscholar +1 more source
Mechanisms of OCT4-SOX2 motif readout on nucleosomes
Science, 2020 Engaging the nucleosome Cell identity is defined by gene expression patterns that are established through the binding of specific transcription factors.
A. Michael +14 more
semanticscholar +1 more source
Structural basis for the inhibition of cGAS by nucleosomes
Science, 2020 Saving a host cell from itself A fundamental mammalian defense mechanism against pathogens and damaged cellular DNA is to recognize DNA fragments in the cytosol and trigger an inflammatory response.
T. Kujirai +8 more
semanticscholar +1 more source
Nucleosome sliding can influence the spreading of histone modifications [PDF]
, 2021 Nucleosomes are the fundamental building blocks of chromatin that not only help in the folding of chromatin but also in carrying epigenetic information. It is known that nucleosome sliding is responsible for dynamically organizing chromatin structure and the resulting gene regulation.
arxiv +1 more source
Interaction of the pioneer transcription factor GATA3 with nucleosomes
Nature Communications, 2020 During cellular reprogramming, the pioneer transcription factor GATA3 binds chromatin, and in a context-dependent manner directs local chromatin remodeling and enhancer formation.
Hiroki Tanaka +7 more
semanticscholar +1 more source
PLoS ONE, 2021 The most basic level of eukaryotic gene regulation is the presence or absence of nucleosomes on DNA regulatory elements. In an effort to elucidate in vivo nucleosome patterns, in vitro studies are frequently used.
David A Bates +7 more
doaj +2 more sources
Specialization of the chromatin remodeler RSC to mobilize partially-unwrapped nucleosomes
eLife, 2020 SWI/SNF-family chromatin remodeling complexes, such as S. cerevisiae RSC, slide and eject nucleosomes to regulate transcription. Within nucleosomes, stiff DNA sequences confer spontaneous partial unwrapping, prompting whether and how SWI/SNF-family ...
Alisha Schlichter +3 more
doaj +1 more source
Live‐cell imaging reveals the interplay between transcription factors, nucleosomes, and bursting
EMBO Journal, 2019 Transcription factors show rapid and reversible binding to chromatin in living cells, and transcription occurs in sporadic bursts, but how these phenomena are related is unknown.
Benjamin T. Donovan +7 more
semanticscholar +1 more source