Results 211 to 220 of about 74,179 (293)
The Double Face of Base Excision Repair: Preventing and Triggering Double‐Strand Breaks
Base excision repair is conserved from bacteria to man, robustly eliminating oxidized bases in DNA and reinserting the appropriate nucleotide to restore an intact double helix. Recent results describe conditions and mechanisms that misregulate long‐patch BER to generate double‐strand breaks, triggering chromosome fragmentation and cell death, altering ...
Susan M. Gasser
wiley +1 more source
Where, When, and How? Integrating Spatiotemporal Cues in Cell Division
Accurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Luca Cirillo +3 more
wiley +1 more source
Native nucleosome-positioning elements as alternatives to the 601 sequence for nucleosome repositioning studies. [PDF]
Chen RW +7 more
europepmc +1 more source
Refined mechanism of promoter nucleosome-depleted regions resetting after replication. [PDF]
Zencir S, Gill JK, Stutz F, Soudet J.
europepmc +1 more source
An octamer of histones H3 and 114 forms a compact complex with DNA of nucleosome size
Richard H. Simon +2 more
openalex +2 more sources
We hypothesize that the TPL corepressor (and likely others) acts as a transcriptional linchpin, stabilizing a state similar yet distinct from the metazoan paused state by recruiting Mediator and other components needed to initiate and coordinate transcriptional bursts across multiple genes.
Alexander R. Leydon +1 more
wiley +1 more source
Comprehensive profiling of chromatin occupancy dynamics through the cell cycle. [PDF]
Li Y, MacAlpine DM, Hartemink AJ.
europepmc +1 more source

