Results 211 to 220 of about 74,179 (293)

The Double Face of Base Excision Repair: Preventing and Triggering Double‐Strand Breaks

open access: yesBioEssays, Volume 48, Issue 1, January 2026.
Base excision repair is conserved from bacteria to man, robustly eliminating oxidized bases in DNA and reinserting the appropriate nucleotide to restore an intact double helix. Recent results describe conditions and mechanisms that misregulate long‐patch BER to generate double‐strand breaks, triggering chromosome fragmentation and cell death, altering ...
Susan M. Gasser
wiley   +1 more source

Where, When, and How? Integrating Spatiotemporal Cues in Cell Division

open access: yesBioEssays, Volume 48, Issue 1, January 2026.
Accurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Luca Cirillo   +3 more
wiley   +1 more source

Native nucleosome-positioning elements as alternatives to the 601 sequence for nucleosome repositioning studies. [PDF]

open access: yesNucleic Acids Res
Chen RW   +7 more
europepmc   +1 more source

Primed to Burst: Corepressors Coordinate Transcriptional Activation and Efficient Switching Between Cell States

open access: yesBioEssays, Volume 48, Issue 1, January 2026.
We hypothesize that the TPL corepressor (and likely others) acts as a transcriptional linchpin, stabilizing a state similar yet distinct from the metazoan paused state by recruiting Mediator and other components needed to initiate and coordinate transcriptional bursts across multiple genes.
Alexander R. Leydon   +1 more
wiley   +1 more source

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