Results 21 to 30 of about 74,179 (293)

Dominant effects of the histone mutant H3-L61R on Spt16-gene interactions in budding yeast

Epigenetics, 2022
Recent studies have unveiled an association between an L61R substitution within the human histone H3.3 protein and the presentation of neurodevelopmental disorders in two patients.
Alex Pablo-Kaiser, McKenzie G. Tucker, Grace A. Turner, Elijah G. Dilday, Avery G. Olmstead, Caroline L. Tackett, Andrea A. Duina   +6 more
doaj   +1 more source

The TFIIH complex is required to establish and maintain mitotic chromosome structure

eLife, 2022
Condensins compact chromosomes to promote their equal segregation during mitosis, but the mechanism of condensin engagement with and action on chromatin is incompletely understood.
Julian Haase, Richard Chen, Wesley M Parker, Mary Kate Bonner, Lisa M Jenkins, Alexander E Kelly   +5 more
doaj   +1 more source

Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription

Cell Reports, 2021
Summary: The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor suppressor. Here, a degron is applied to detect rapid loss of chromatin accessibility at thousands of loci where ARID1A acts to generate accessible minidomains of ...
Seraina Blümli, Nicola Wiechens, Meng-Ying Wu, Vijender Singh, Marek Gierlinski, Gabriele Schweikert, Nick Gilbert, Catherine Naughton, Ramasubramanian Sundaramoorthy, Joby Varghese, Robert Gourlay, Renata Soares, David Clark, Tom Owen-Hughes   +13 more
doaj   +1 more source

Interaction of the pioneer transcription factor GATA3 with nucleosomes

Nature Communications, 2020
During cellular reprogramming, the pioneer transcription factor GATA3 binds chromatin, and in a context-dependent manner directs local chromatin remodeling and enhancer formation.
Hiroki Tanaka, Y. Takizawa, Motoki Takaku, Daiki Kato, Yusuke Kumagawa, Sara A. Grimm, P. Wade, H. Kurumizaka   +7 more
semanticscholar   +1 more source

Cellular uptake of extracellular nucleosomes induces innate immune responses by binding and activating cGMP-AMP synthase (cGAS)

Scientific Reports, 2020
The nucleosome is the basic structural repeating unit of chromatin. DNA damage and cell apoptosis release nucleosomes into the blood circulatory system, and increased levels of circulating nucleosomes have been observed to be related to inflammation and ...
Huawei Wang, Chuanlong Zang, Mengtian Ren, Mengdi Shang, Zhenghua Wang, Xuemei Peng, Qiangzhe Zhang, Xin Wen, Zhen Xi, Chuanzheng Zhou   +9 more
doaj   +1 more source

EXTRACELLULAR DNA AND THE LEVEL OF ITS METHYLATION IN DIFFERENT RHEUMATIC DISEASES

Научно-практическая ревматология, 2012
Objective: to study the qualitative and quantitative composition of serum extracellular DNA (exDNA); apoptotic (nucleosomes) and necrotic fragmentation; complexification of monometinic proteins with exDNA; and the levels of exDNA methylation as compared ...
N O Shubayeva, V A Kuzmin, O A Kupavtseva, E N Aleksandrova, A I Speransky   +4 more
doaj   +1 more source

A species-specific nucleosomal signature defines a periodic distribution of amino acids in proteins [PDF]

Open Biology, 2015
Nucleosomes are the basic structural units of chromatin. Most of the yeast genome is organized in a pattern of positioned nucleosomes that is stably maintained under a wide range of physiological conditions.
Luis Quintales, Ignacio Soriano, Enrique Vázquez, Mónica Segurado, Francisco Antequera   +4 more
doaj   +1 more source

Gammaretroviruses tether to mitotic chromatin by directly binding nucleosomal histone proteins

Microbial Cell, 2018
The gammaretroviral gag cleavage product, p12, is essential for replication at both early and late stages of the virus life cycle. During the early stage of infection, the viral core is released into the cytoplasm, the viral RNA genome is reversed ...
Madushi Wanaguru, Kate N. Bishop
doaj   +1 more source

The esBAF and ISWI nucleosome remodeling complexes influence occupancy of overlapping dinucleosomes and fragile nucleosomes in murine embryonic stem cells

BMC Genomics, 2023
Background Nucleosome remodeling factors regulate the occupancy and positioning of nucleosomes genome-wide through ATP-driven DNA translocation. While many nucleosomes are consistently well-positioned, some nucleosomes and alternative nucleosome ...
David C. Klein, Kris Troy, Sarah A. Tripplehorn, Sarah J. Hainer   +3 more
doaj   +1 more source

Live‐cell imaging reveals the interplay between transcription factors, nucleosomes, and bursting

EMBO Journal, 2019
Transcription factors show rapid and reversible binding to chromatin in living cells, and transcription occurs in sporadic bursts, but how these phenomena are related is unknown.
Benjamin T. Donovan, Anh Huynh, David A. Ball, Heta P. Patel, M. Poirier, D. Larson, M. Ferguson, T. Lenstra   +7 more
semanticscholar   +1 more source