Results 21 to 30 of about 72,215 (324)
Proceedings of the National Academy of Sciences, 1997 Archaeacontain histones that have primary sequences in common with eukaryal nucleosome core histones and a three-dimensional structure that is essentially only the histone fold. Here we report the results of experiments that document that archaeal histones compact DNAin vivointo structures similar to the structure formed by the histone (H3+H4)2tetramer
Rudi Lurz +3 more
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Interaction of the pioneer transcription factor GATA3 with nucleosomes
Nature Communications, 2020 During cellular reprogramming, the pioneer transcription factor GATA3 binds chromatin, and in a context-dependent manner directs local chromatin remodeling and enhancer formation.
Hiroki Tanaka +7 more
semanticscholar +1 more source
Pathogens, 2021 (1) Background: Hepatocellular carcinoma (HCC) is the most serious complication of chronic hepatitis B (CHB). Recently, the detection of circulating cell-free (cf) DNA and nucleosomes has found numerous applications in oncology.
Alkistis Papatheodoridi +4 more
doaj +1 more source
The insulator binding protein CTCF positions 20 nucleosomes around its binding sites across the human genome. [PDF]
PLoS Genetics, 2008 Chromatin structure plays an important role in modulating the accessibility of genomic DNA to regulatory proteins in eukaryotic cells. We performed an integrative analysis on dozens of recent datasets generated by deep-sequencing and high-density tiling ...
Yutao Fu +3 more
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The Role of Histone Variants in the Epithelial-To-Mesenchymal Transition
Cells, 2020 The epithelial-to-mesenchymal transition (EMT) is a physiological process activated during early embryogenesis, which continues to shape tissues and organs later on. It is also hijacked by tumor cells during metastasis. The regulation of EMT has been the
Imtiaz Nisar Lone +4 more
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Nucleosome Positioning, Nucleosome Spacing and the Nucleosome Code [PDF]
Journal of Biomolecular Structure and Dynamics, 2010 Nucleosome positioning has been the subject of intense study for many years. The properties of micrococcal nuclease, the enzyme central to these studies, are discussed. The various methods used to determine nucleosome positions in vitro and in vivo are reviewed critically.
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Nucleosome—nucleosome interaction in chromatin
FEBS Letters, 1979 The available data suggest that transcriptional activity of chromatin is connected with its structural changes [ 1,2]. According to the electron microscope evidence, the elementary 100 A chromatin thread can exist in two main states, i.e., in a compact state, which is characterized by tight packing of nucleosomes and in an extended state when the ...
S. B. Svetlikova +2 more
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Specialization of the chromatin remodeler RSC to mobilize partially-unwrapped nucleosomes
eLife, 2020 SWI/SNF-family chromatin remodeling complexes, such as S. cerevisiae RSC, slide and eject nucleosomes to regulate transcription. Within nucleosomes, stiff DNA sequences confer spontaneous partial unwrapping, prompting whether and how SWI/SNF-family ...
Alisha Schlichter +3 more
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Abstract P-18: PARP1-Induced Structural Rearrangements are Enhanced in Cisplatin-Treated Nucleosomes [PDF]
International Journal of Biomedicine, 2019 Background: Cisplatin (Fig. 1) is a low molecular weight platinum-containing compound with a square planar geometry. It is widely used for the treatment of different cancers.
Natalya Maluchenko +4 more
doaj +1 more source
Dissociation rate compensation mechanism for budding yeast pioneer transcription factors
eLife, 2019 Nucleosomes restrict the occupancy of most transcription factors (TF) by reducing binding and accelerating dissociation, while a small group of TFs have high affinities to nucleosome-embedded sites and facilitate nucleosome displacement.
Benjamin T Donovan +4 more
doaj +1 more source