Specialization of the chromatin remodeler RSC to mobilize partially-unwrapped nucleosomes
SWI/SNF-family chromatin remodeling complexes, such as S. cerevisiae RSC, slide and eject nucleosomes to regulate transcription. Within nucleosomes, stiff DNA sequences confer spontaneous partial unwrapping, prompting whether and how SWI/SNF-family ...
Alisha Schlichter+3 more
doaj +1 more source
Abstract P-18: PARP1-Induced Structural Rearrangements are Enhanced in Cisplatin-Treated Nucleosomes [PDF]
Background: Cisplatin (Fig. 1) is a low molecular weight platinum-containing compound with a square planar geometry. It is widely used for the treatment of different cancers.
Natalya Maluchenko+4 more
doaj +1 more source
Conserved substitution patterns around nucleosome footprints in eukaryotes and Archaea derive from frequent nucleosome repositioning through evolution. [PDF]
Nucleosomes, the basic repeat units of eukaryotic chromatin, have been suggested to influence the evolution of eukaryotic genomes, both by altering the propensity of DNA to mutate and by selection acting to maintain or exclude nucleosomes in particular ...
Becker, Erin+4 more
core +2 more sources
Dissociation rate compensation mechanism for budding yeast pioneer transcription factors
Nucleosomes restrict the occupancy of most transcription factors (TF) by reducing binding and accelerating dissociation, while a small group of TFs have high affinities to nucleosome-embedded sites and facilitate nucleosome displacement.
Benjamin T Donovan+4 more
doaj +1 more source
Nucleosomes indicate the in vitro radiosensitivity of irradiated bronchoepithelial and lung cancer cells [PDF]
Nucleosomes, which are typical cell death products, are elevated in the serum of cancer patients and are known to rapidly increase during radiotherapy.
Al-Batran SE+14 more
core +1 more source
Evaluation of nucleosome forming potentials (NFPs) of forensically important STRs [PDF]
Degraded forensic samples have proved difficult to analyze and interpret. New analysis techniques are constantly being discovered and improved but researchers have overlooked the structural properties that could prevent or slow the process of degradation.
Thanakiatkrai, Phuvadol, Welch, Lindsey
core +1 more source
The dynamics of individual nucleosomes controls the chromatin condensation pathway: direct AFM visualization of variant chromatin [PDF]
Chromatin organization and dynamics is studied in this work at scales ranging from single nucleosome to nucleosomal array by using a unique combination of biochemical assays, single molecule imaging technique and numerical modeling. We demonstrate that a
Akiyama+42 more
core +4 more sources
Live‐cell imaging reveals the interplay between transcription factors, nucleosomes, and bursting
Transcription factors show rapid and reversible binding to chromatin in living cells, and transcription occurs in sporadic bursts, but how these phenomena are related is unknown.
Benjamin T. Donovan+7 more
semanticscholar +1 more source
Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms [PDF]
Alteration of chromatin structure by chromatin modifying and remodelling activities is a key stage in the regulation of many nuclear processes. These activities are frequently interlinked, and many chromatin remodelling enzymes contain motifs that ...
Ferreira, Helder+2 more
core +3 more sources
Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes
Epigenetic regulation is mediated by protein complexes that couple recognition of chromatin marks to activity or recruitment of chromatin-modifying enzymes. Polycomb repressive complex 2 (PRC2), a gene silencer that methylates lysine 27 of histone H3, is
S. Poepsel, V. Kasinath, E. Nogales
semanticscholar +1 more source