Results 31 to 40 of about 80,558 (329)

The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains [PDF]

, 2011
The ATP-dependent chromatin-remodelling enzyme Chd1 is a 168-kDa protein consisting of a double chromodomain, Snf2-related ATPase domain, and a C-terminal DNA-binding domain.
Aasland, Adams, Alen, Awad, Bailey, Baker, Baudin, Bird, Biswas, Biswas, Blank, Blosser, Boyer, Cairns, Chen, Cheng, Clapier, Clapier, Corona, Dang, Daniel P Ryan, Daubresse, David Martin, de Vries, Delmas, Eberharter, Eddy, Emsley, Fazzio, Ferreira, Flanagan, Flaus, Gangaraju, Gaspar-Maia, Grune, Hamiche, Hauk, Holm, Konev, Kouzarides, Lin, Lusser, McDaniel, Morettini, Okuda, Painter, Park, Pinskaya, Racki, Ramasubramanian Sundaramoorthy, Robinson, Sikorski, Simic, Sims, Stockdale, Stokes, Thastrom, Thompson, Tom Owen-Hughes, Tran, Tsukiyama, Vijender Singh, Walfridsson, Waterhouse, Yang, Zentner   +65 more
core   +3 more sources

Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome [PDF]

, 2007
Objective: Previous studies have shown the importance of somatic mutations and arginine residues in the complementarity-determining regions (CDRs) of pathogenic anti-double-stranded DNA (anti-dsDNA) antibodies in human and murine lupus, and in studies of
Giles, I., Ioannou, Y., Isenberg, D.A., Lambrianides, A., Latchman, D.S., Manson, J.J., Mason, L., Rahman, A.   +7 more
core   +1 more source

DNA-encoded nucleosome occupancy is associated with transcription levels in the human malaria parasite Plasmodium falciparum. [PDF]

, 2014
BackgroundIn eukaryotic organisms, packaging of DNA into nucleosomes controls gene expression by regulating access of the promoter to transcription factors.
Bunnik, Evelien M, Gill, Sarjeet S, Le Roch, Karine G, Lonardi, Stefano, Polishko, Anton, Ponts, Nadia, Prudhomme, Jacques   +6 more
core   +3 more sources

Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription

Cell Reports, 2021
Summary: The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor suppressor. Here, a degron is applied to detect rapid loss of chromatin accessibility at thousands of loci where ARID1A acts to generate accessible minidomains of ...
Seraina Blümli, Nicola Wiechens, Meng-Ying Wu, Vijender Singh, Marek Gierlinski, Gabriele Schweikert, Nick Gilbert, Catherine Naughton, Ramasubramanian Sundaramoorthy, Joby Varghese, Robert Gourlay, Renata Soares, David Clark, Tom Owen-Hughes   +13 more
doaj  

Mechanical properties of nucleoprotein complexes determined by nanoindentation spectroscopy

Nucleus, 2020
The interplay between transcription factors, chromatin remodelers, 3-D organization, and mechanical properties of the chromatin fiber controls genome function in eukaryotes.
Tatini Rakshit, Daniël P. Melters, Emilios K. Dimitriadis, Yamini Dalal   +3 more
doaj   +1 more source

Nucleosomes and neutrophil extracellular traps in septic and burn patients [PDF]

, 2017
NETosis is a host defense mechanism associated with inflammation and tissue damage. Experimental models show that platelets and von Willebrand factor (VWF) are key elements for intravascular NETosis. We determined NETosis in septic and burn patients at 1
Carestia, Agostina, D'Atri, Lina Paola, Fandiño, María Eugenia, Fondevila, Carlos, Guzman, María Alejandra, Kaufman, Tomás, Magosevich, Débora, Moreno, María Carolina, Schattner, Mirta Ana   +8 more
core   +1 more source

Mediator–Nucleosome Interaction [PDF]

Molecular Cell, 2000
Mediator, a multiprotein complex involved in the regulation of RNA polymerase II transcription, binds to nucleosomes and acetylates histones. Three lines of evidence identify the Nut1 subunit of Mediator as responsible for the histone acetyltransferase (HAT) activity. An "in-gel" HAT assay reveals a single band of the appropriate size.
Lawrence C. Myers, Yahli Lorch, Roger D. Kornberg, Claes M. Gustafsson, Jenny Beve   +4 more
openaire   +3 more sources

Charged residues on the side of the nucleosome contribute to normal Spt16-gene interactions in budding yeast

Epigenetics, 2018
Previous work in Saccharomyces cerevisiae identified three residues located in close proximity to each other on the side of the nucleosome whose integrity is required for proper association of the Spt16 component of the FACT complex across transcribed ...
Eugene Nyamugenda, A. Brandon Cox, Jacob B. Pierce, Ryan C. Banning, Michelle L. Huynh, Catey May, Sarah Marshall, Claire E. Turkal, Andrea A. Duina   +8 more
doaj   +1 more source

TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization [PDF]

, 2015
The ends of eukaryotic chromosomes need to be protected from the activation of a DNA damage response that leads the cell to replicative senescence or apoptosis.
Alicata, Claudia, Cacchione, Stefano, Cicconi, Alessandro, Galati, Alessandra, Gilson, Eric, Giraud Panis, Marie Josèphe, Ingegnere, Tiziano, Micheli, Emanuela, Pusch, Miriam Caroline   +8 more
core   +2 more sources

The Significance of Circulating Cell-Free DNA Markers in Chronic Hepatitis B Patients with Hepatocellular Carcinoma

Pathogens, 2021
(1) Background: Hepatocellular carcinoma (HCC) is the most serious complication of chronic hepatitis B (CHB). Recently, the detection of circulating cell-free (cf) DNA and nucleosomes has found numerous applications in oncology.
Alkistis Papatheodoridi, Nikolaos Karakousis, Panagiotis Lembessis, Antonios Chatzigeorgiou, George V. Papatheodoridis   +4 more
doaj   +1 more source