Results 31 to 40 of about 69,179 (216)

Control of nucleosome movement: To space or not to space nucleosomes? [PDF]

Epigenetics, 2010
A key feature of ATP-dependent chromatin remodeling complexes is how they control the ability of the complex to translocate along DNA within the context of a nucleosome. Although these complexes generally initiate DNA translocation near the dyad axis of the nucleosome, the progression and eventual termination is regulated in quite distinct ways.
Blaine Bartholomew, Punit Prasad
openaire   +3 more sources

The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains [PDF]

, 2011
The ATP-dependent chromatin-remodelling enzyme Chd1 is a 168-kDa protein consisting of a double chromodomain, Snf2-related ATPase domain, and a C-terminal DNA-binding domain.
Aasland, Adams, Alen, Awad, Bailey, Baker, Baudin, Bird, Biswas, Biswas, Blank, Blosser, Boyer, Cairns, Chen, Cheng, Clapier, Clapier, Corona, Dang, Daniel P Ryan, Daubresse, David Martin, de Vries, Delmas, Eberharter, Eddy, Emsley, Fazzio, Ferreira, Flanagan, Flaus, Gangaraju, Gaspar-Maia, Grune, Hamiche, Hauk, Holm, Konev, Kouzarides, Lin, Lusser, McDaniel, Morettini, Okuda, Painter, Park, Pinskaya, Racki, Ramasubramanian Sundaramoorthy, Robinson, Sikorski, Simic, Sims, Stockdale, Stokes, Thastrom, Thompson, Tom Owen-Hughes, Tran, Tsukiyama, Vijender Singh, Walfridsson, Waterhouse, Yang, Zentner   +65 more
core   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Modeling the dynamics of bivalent histone modifications [PDF]

, 2013
Epigenetic modifications to histones may promote either activation or repression of the transcription of nearby genes. Recent experimental studies show that the promoters of many lineage-control genes in stem cells have "bivalent domains" in which the ...
Girvan, Michelle, Ku, Wai Lim, Ott, Edward, Sorrentino, Francesco, Yuan, Guo-Cheng   +4 more
core   +12 more sources

High-throughput sequencing reveals a simple model of nucleosome energetics

, 2010
We use nucleosome maps obtained by high-throughput sequencing to study sequence specificity of intrinsic histone-DNA interactions. In contrast with previous approaches, we employ an analogy between a classical one-dimensional fluid of finite-size ...
A. V. Morozov, Adams, D. Tolkunov, Deckert, Fedor, Felsenfeld, Field, G. Locke, Horz, Ioshikhes, Jenuwein, K. Struhl, Kaplan, Kornberg, Lee, Mavrich, Miller, Richmond, Segal, Sekinger, Tillo, Tolstorukov, Wang, Widom, Wingert, Yuan, Z. Moqtaderi   +26 more
core   +1 more source

The dynamics of individual nucleosomes controls the chromatin condensation pathway: direct AFM visualization of variant chromatin [PDF]

, 2009
Chromatin organization and dynamics is studied in this work at scales ranging from single nucleosome to nucleosomal array by using a unique combination of biochemical assays, single molecule imaging technique and numerical modeling. We demonstrate that a
Akiyama, Angelov, Bao, Boulard, Cendrine Faivre-Moskalenko, Chadwick, Claudet, Dalal, Dimitar Angelov, Doyen, Fabien Montel, Gautier, Gonzales, Gonzalez-Romero, Hervé Menoni, Huynh, Jan Bednar, Kepert, Koch, Lebedev, Lowary, Luger, Luger, Lyubchenko, Martin Castelnovo, Menoni, Montel, Mutskov, Poirier, Robinson, Robinson, Routh, Schalch, Schiessel, Shogren-Knaak, Sims, Stefan Dimitrov, Valle, van Holde, Wu, Yodh, Zhou, Zlatanova   +42 more
core   +4 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Nucleosome destabilization by polyamines

Archives of Biochemistry and Biophysics, 2022
The roles and molecular interactions of polyamines (PAs) in the nucleus are not fully understood. Here their effect on nucleosome stability, a key regulatory factor in eukaryotic gene control, is reported, as measured in agarose embedded nuclei of H2B-GFP expressor HeLa cells.
Laszlo Imre, Erfaneh Firouzi Niaki, Rosevalentine Bosire, Peter Nanasi, Peter Nagy, Zsolt Bacso, Nubar Hamidova, Yves Pommier, Albert Jordan, Gabor Szabo   +9 more
openaire   +3 more sources

Hyperoxia Induced Alteration of Chromatin Structure in Human Bone Marrow Derived Primary Mesenchymal Stromal Cells

Advanced Biology, EarlyView.
Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and found variability in how different parts of chromatin remodel.
Lauren Monroe, Samantha Kaonis, Natalie Calahan, Neda Kabi, Soham Ghosh   +4 more
wiley   +1 more source

Quantitative Analysis of Single-Molecule Force Spectroscopy on Folded Chromatin Fibers

, 2015
Single-molecule techniques allow for picoNewton manipulation and nanometer accuracy measurements of single chromatin fibers. However, the complexity of the data, the heterogeneity of the composition of individual fibers and the relatively large ...
Andresen, Kurt, Meng, He, Van Noort, John   +2 more
core   +2 more sources