Unveiling a novel memory center in human brain: neurochemical identification of the nucleus incertus, a key pontine locus implicated in stress and neuropathology [PDF]
Biological ResearchBackground The nucleus incertus (NI) was originally described by Streeter in 1903, as a midline region in the floor of the fourth ventricle of the human brain with an ‘unknown’ function.
Camila de Ávila +14 more
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Sox2 Ablation in the Suprachiasmatic Nucleus Perturbs Anxiety- and Depressive-like Behaviors [PDF]
Neurology International, 2021 Mood disorders negatively impact the lives of hundreds of millions of individuals worldwide every year, yet the precise molecular mechanisms by which they manifest remain elusive.
Nicholas A. Boehler +4 more
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Silencing relaxin-3 in nucleus incertus of adult rodents: a viral vector-based approach to investigate neuropeptide function. [PDF]
PLoS ONE, 2012 Relaxin-3, the most recently identified member of the relaxin peptide family, is produced by GABAergic projection neurons in the nucleus incertus (NI), in the pontine periventricular gray.
Gabrielle E Callander +6 more
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Sex hormones in the nucleus incertus: a novel perspective on sex/gender differences in memory and mood dysfunction in Alzheimer’s disease [PDF]
Frontiers in Aging NeuroscienceAbout 60% of the individuals living with Alzheimer’s disease (AD) in the United States are women. Increasing evidence points to a role for sex hormones, especially estrogen, in making women more vulnerable to AD than men.
Camila de Ávila +5 more
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NUCLEUS INCERTUS RESPONSES TO AN AVERSIVE STIMULUS
IBRO Neuroscience Reports, 2023 Olga Mierniczek +6 more
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Hypothalamic-hindbrain circuit for consumption-induced fear regulation [PDF]
Nature CommunicationsTo ensure survival, animals must sometimes suppress fear responses triggered by potential threats during feeding. However, the mechanisms underlying this process remain poorly understood.
Qin Wang +7 more
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Brainstem nucleus incertus controls contextual memory formation. [PDF]
Science, 2019 What inhibits the inhibitors? In the hippocampus, each memory trace is encoded by a specific subset of pyramidal cells. The other pyramidal cells must be actively excluded from the memory encoding process by inhibition, which is done by selective dendrite-targeting interneurons. Szőnyi et al.
Szőnyi A +14 more
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Neuropeptide S (NPS) neurons: Parabrachial identity and novel distributions. [PDF]
J Comp Neurol, 2022 Neuropeptide S (NPS) neurons in the parabrachial region are a subset of Atoh1‐derived, Foxp2‐expressing neurons that do not express Pdyn, Calca, or Cck. We also identified novel populations of NPS neurons from Cre‐reporter expression in the nucleus incertus, anterior hypothalamus, and lateral habenula.
Huang D +5 more
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Mapping Cell Types and Efferent Pathways in the Ascending Relaxin-3 System of the Nucleus Incertus. [PDF]
eNeuro, 2020 AbstractRelaxin-3 (Rln3) is an insulin-family peptide neurotransmitter expressed primarily in neurons of the nucleus incertus (NI) of the pontine tegmentum, with smaller populations located in the deep mesencephalon (DpMe) and periaqueductal gray (PAG). Here, we have used targeted recombination at theRln3gene locus to generate anRln3Cretransgenic mouse
Nasirova N +4 more
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Modulation of forebrain function by nucleus incertus and relaxin-3/RXFP3 signaling. [PDF]
CNS Neurosci Ther, 2018 SummaryThe nucleus incertus (NI) in the pontine tegmentum sends ascending projections to the midbrain, hypothalamus, amygdala, basal forebrain, hippocampus, and prefrontal cortex, and has a postulated role in modulating several forebrain functions. A substantial population of GABAergic NI neurons expresses the neuropeptide, relaxin‐3, which acts via ...
Olucha-Bordonau FE +7 more
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