Results 21 to 30 of about 378 (120)

Nicotinic Receptors in the Medial Habenula to Interpeduncular Nucleus Pathway: Modulators of Reward, Aversion and Emotion. [PDF]

Eur J Neurosci
ABSTRACT The medial habenula–interpeduncular nucleus pathway is a highly conserved and densely innervated brain circuit known for its unique cholinergic transmission and exceptional expression of nicotinic acetylcholine receptors. This pathway plays a critical role in regulating motivational and emotional processes, particularly those related to ...
Ciscato M, Chouvaeff M, Mourot A.
europepmc   +2 more sources

Postnatal development of the relaxin-3 innervation of the rat medial septum

Frontiers in Neuroscience, 2023
IntroductionThe septal area provides a rich innervation to the hippocampus regulating hippocampal excitability to different behavioral states and modulating theta rhythmogenesis.
Francisco Ros-Bernal, Isis Gil-Miravet, Jorge Lucerón, Mónica Navarro-Sánchez, Esther Castillo-Gómez, Esther Castillo-Gómez, Andrew L. Gundlach, Francisco E. Olucha-Bordonau, Francisco E. Olucha-Bordonau   +8 more
doaj   +1 more source

Efferent projections of Nps-expressing neurons in the parabrachial region. [PDF]

J Comp Neurol
We mapped the efferent projections of neuropeptide S (NPS) neurons in the parabrachial nucleus and peri‐locus coeruleus using a genetic approach combined with a neural network algorithm (BoutonNet). NPS neurons project via a periventricular and ventral pathway and target the paraventricular nucleus of the thalamus, bed nucleus of the stria terminalis ...
Zhang R, Huang D, Gasparini S, Geerling JC.   +3 more
europepmc   +2 more sources

Brainwide Projections of Mouse Dopaminergic Zona Incerta Neurons. [PDF]

J Comp Neurol
Cre‐dependent viral tracing from medial dopaminergic ZI neurons revealed abundant fiber projections rostrocaudally throughout the brain. Interestingly, the midbrain motor regions, including the periaqueductal gray area and superior colliculus, contained the densest accumulation of fiber projections, and this fiber density was independent of the region ...
Bono BS, Negishi K, Dumiaty Y, Ponce-Ruiz MS, Akinbode TC, Baker KS, Spencer CDP, Mejia E, Guirguis M, Hebert AJ, Khan AM, Chee MJ.   +11 more
europepmc   +2 more sources

Contribution of hypothalamic orexin (hypocretin) circuits to pathologies of motivation. [PDF]

Br J Pharmacol
Abstract The orexin (also known as hypocretin) system, consisting of neuropeptides orexin‐A and orexin‐B, was discovered over 25 years ago and was immediately identified as a central regulator of sleep and wakefulness. These peptides interact with two G‐protein coupled receptors, orexin 1 (OX1) and orexin 2 (OX2) receptors which are capable of coupling
Mohammadkhani A, Mitchell C, James MH, Borgland SL, Dayas CV.   +4 more
europepmc   +2 more sources

History of key regulatory peptide systems and perspectives for future research

Journal of Neuroendocrinology, Volume 35, Issue 11, November 2023., 2023
The history of the International Regulatory Peptide Society and RegPep symposia reflects the evolution of regulatory peptide discovery since 1902, which is exemplified by scientific works of Viktor Mutt, Wylie W. Vale Jr and Rolf Håkanson and research on corticotropin‐releasing factor (CRF), enterochromaffin‐like (ECL) cells, cholecystokinin (CCK ...
Duan Chen, Jens F. Rehfeld, Alan G. Watts, Patrik Rorsman, Andrew L. Gundlach   +4 more
wiley   +1 more source

Trans-Synaptic Virus Tracing Reveals Reciprocal Connections of the Interpeduncular Nucleus With the Mood, Exteroceptive, Interoceptive, and Motor Control Systems. [PDF]

J Comp Neurol
The interpeduncular nucleus (IPN) in zebrafish plays a pivotal role in directional decision‐making, social conflict, and fear responses. The anterograde and retrograde connections of the dorsal and intermediate IPN are revealed through the use of monosynaptic and trans‐synaptic viral tracers.
Wong AK, Cherng BW, Kakinuma H, Wyart C, Okamoto H.   +4 more
europepmc   +2 more sources

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

British Journal of Pharmacology, Volume 180, Issue S2, Page S23-S144, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Arthur Christopoulos, Anthony P. Davenport, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Maria Pia Abbracchio, George Abraham, Alexander Agoulnik, Wayne Alexander, Khaled Al‐hosaini, Magnus Bäck, Jillian G. Baker, Nicholas M. Barnes, Ross Bathgate, Jean‐Martin Beaulieu, Annette G. Beck‐Sickinger, Maik Behrens, Kenneth E. Bernstein, Bernhard Bettler, Nigel J. M. Birdsall, Victoria Blaho, Francois Boulay, Corinne Bousquet, Hans Bräuner‐Osborne, Geoffrey Burnstock, Girolamo Caló, Justo P. Castaño, Kevin J. Catt, Stefania Ceruti, Paul Chazot, Nan Chiang, Bice Chini, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H. Clapp, Réjean Couture, Helen M. Cox, Zsolt Csaba, Claes Dahlgren, Gordon Dent, Steven D. Douglas, Pascal Dournaud, Satoru Eguchi, Emanuel Escher, Edward J. Filardo, Tung Fong, Marta Fumagalli, Raul R. Gainetdinov, Michael L. Garelja, Marc de Gasparo, Craig Gerard, Marvin Gershengorn, Fernand Gobeil, Theodore L. Goodfriend, Cyril Goudet, Lukas Grätz, Karen J. Gregory, Andrew L. Gundlach, Jörg Hamann, Julien Hanson, Richard L. Hauger, Debbie L. Hay, Akos Heinemann, Deron Herr, Morley D. Hollenberg, Nicholas D. Holliday, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P. IJzerman, Tadashi Inagami, Kenneth A. Jacobson, Robert T. Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Yasuyuki Kihara, Takio Kitazawa, Pawel Kozielewicz, Hans‐Jürgen Kreienkamp, Jyrki P. Kukkonen, Tobias Langenhan, Dan Larhammar, Katie Leach, Davide Lecca, John D. Lee, Susan E. Leeman, Jérôme Leprince, Xaria X. Li, Stephen J. Lolait, Amelie Lupp, Robyn Macrae, Janet Maguire, Davide Malfacini, Jean Mazella, Craig A. McArdle, Shlomo Melmed, Martin C. Michel, Laurence J. Miller, Vincenzo Mitolo, Bernard Mouillac, Christa E. Müller, Philip M. Murphy, Jean‐Louis Nahon, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne‐Marie O’Carroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Roger G. Pertwee, Jean‐Philippe Pin, Eric R. Prossnitz, Mark Quinn, Rithwik Ramachandran, Manisha Ray, Rainer K. Reinscheid, Philippe Rondard, G. Enrico Rovati, Chiara Ruzza, Gareth J. Sanger, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L. Segaloff, Charles N. Serhan, Khuraijam Dhanachandra Singh, Craig M. Smith, Leigh A. Stoddart, Yukihiko Sugimoto, Roger Summers, Valerie P. Tan, David Thal, Walter ( Wally) Thomas, Pieter B. M. W. M. Timmermans, Kalyan Tirupula, Lawrence Toll, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Jean‐Pierre Vilardaga, Christopher S. Walker, Ji Ming Wang, Donald T. Ward, Hans‐Jürgen Wester, Gary B. Willars, Tom Lloyd Williams, Trent M. Woodruff, Chengcan Yao, Richard D. Ye   +165 more
wiley   +1 more source

Macroscale connections of the mouse lateral preoptic area and anterior lateral hypothalamic area

Journal of Comparative Neurology, Volume 530, Issue 13, Page 2254-2285, September 2022., 2022
Prominent multilevel lateral preoptic area (LPO) and lateral hypothalamic area anterior region (LHAa) functional associations. Three nested tiers of functional grouping are represented (gray shaded tiles), and for each is listed functional grouping‐related gray matter regions with prominent connections to LPO and LHAa; outputs and inputs are indicated ...
Joel D. Hahn, Lei Gao, Tyler Boesen, Lin Gou, Houri Hintiryan, Hong‐Wei Dong   +5 more
wiley   +1 more source

Relaxin family peptide receptor 3 (RXFP3) expressing cells in the zona incerta/lateral hypothalamus augment behavioural arousal. [PDF]

J Neurochem
Relaxin family peptide receptor 3 (RXFP3) is an inhibitory G‐protein coupled receptor expressed widely throughout the mammalian brain. We show that RXFP3‐expressing cells in the mouse zona incerta and lateral hypothalamus (LH/ZIRXFP3) send efferent projections to fear and arousal‐implicated nuclei.
Richards BK, Ch'ng SS, Simon AB, Pang TY, Kim JH, Lawrence AJ, Perry CJ.   +6 more
europepmc   +2 more sources