Results 171 to 180 of about 2,433 (185)

NUDT15 polymorphism in healthy children with Bai nationality in Yunnan of China

Pediatrics International, 2021
AbstractBackgroundThiopurine methyltransferase (TPMT) polymorphism is one of the causes of the toxicity of thiopurines, but this is rarely seen in Asian populations. Rather, the nucleoside diphosphate‐linked X‐component motif 15 (NUDT15) gene is frequently linked to mercaptopurine (MP) intolerance and myelotoxicity in children with acute lymphoblastic ...
Gangling Pu, Yali Wang, Shaoqin Duan, Jingpei Chen, Chunhui Yang, Tingting Cui, Chunlian Fang, Yan Zhou, Han Zhang, Xin Tian   +9 more
openaire   +2 more sources

Preemptive NUDT15 genotyping: redefining the management of patients with thiopurine-induced toxicity

Drug Metabolism and Personalized Therapy, 2018
AbstractBackground:Thiopurine methyltransferase (TPMT) gene variants have achieved limited success in predicting the outcome of thiopurine therapy, which shows wide inter-individual variations. The literature indicates a strong association between theNUDT15gene variant and thiopurine-induced toxicity in Asian patients.
Swarup A.V. Shah, Minal U. Paradkar, Devendra C. Desai, Tester F. Ashavaid   +3 more
openaire   +2 more sources

472 - NUDT15 Variants Contribute to Thiopurine-Induced Myelosuppression in European Populations

Gastroenterology, 2018
Introduction Thiopurines are commonly used in the maintenance treatment of inflammatory bowel disease (IBD) but this is limited by myelosuppression in 7% of patients.1 Thiopurine S-methyltransferase (TPMT) variants only explain 20% of thiopurine-induced myelosuppression (TIM) in Europeans suggesting the presence of other genetic determinants.2 We ...
Gareth J. Walker, James W. Harrison, Michiel D. Voskuil, Graham A. Heap, Neel Heerasing, Peter J. Hendy, Jukka Koskela, Mark J. Daly, Harry Sokol, Rinse K. Weersma, Dermot McGovern, Claire M. Bewshea, Mike Weedon, James Goodhand, Nicholas A. Kennedy, Tariq Ahmad   +15 more
openaire   +1 more source

NUDT15 Variants Alter Thiopurine-Associated Hematopoietic Toxicity

Cancer Discovery, 2016
Abstract Inactivating NUDT15 polymorphisms are associated with thiopurine intolerance.
openaire   +1 more source

Nudt15-mediated inflammatory signaling contributes to divergent outcomes in leukemogenesis and hematopoiesis

Leukemia
NUDT15 encodes nucleotide triphosphate diphosphatase that is responsible for metabolizing purine analog drugs, and its genetic mutation results in severe side effects from thiopurine therapy. However, the functions of Nudt15 in leukemic stem cells (LSCs) and hematopoietic stem cells (HSCs) remain unknown.
Jiachen Wang, Yu Zhang, Lei Li, Liujiao Wang, Shuainan Sun, Bowu Wang, Yanwen Ge, Zhonghui Zhang   +7 more
openaire   +2 more sources

Characterization of Reference Materials for TPMT and NUDT15

The Journal of Molecular Diagnostics, 2022
Victoria M. Pratt, Wendy Y. Wang, Erin C. Boone, Ulrich Broeckel, Neal Cody, Lisa Edelmann, Andrea Gaedigk, Ty C. Lynnes, Elizabeth B. Medeiros, Ann M. Moyer, Matthew W. Mitchell, Stuart A. Scott, Petr Starostik, Amy Turner, Lisa V. Kalman   +14 more
openaire   +1 more source

Genetic variants in NUDT15 gene their clinical implications in cancer therapy

Drug Metabolism and Personalized Therapy
Abstract Individual variations in the response to thiopurine-based anticancer drugs are influenced by genetic and environmental factors, making it challenging to optimize dosing and minimize toxicity. Among the key genes involved, genetic variations in the nudix hydrolase 15 (NUDT15) gene affect on thiopurine metabolism, thus influencing
Yazun, Jarrar, Maria, Ghishan, Fatima, Khirfan, Nancy, Hakooz   +3 more
openaire   +2 more sources

Novel risk factor for valganciclovir toxicity—NUDT15 genetic variant

Transplant Infectious Disease, 2022
Ashay Shingare, Nikhil Dhope, Madan M. Bahadur   +2 more
openaire   +2 more sources

NUDT15 genotype testing in inflammatory bowel disease patients in Australia

Internal Medicine Journal, 2022
Natalie Yu, Jonathan P. Segal, Nik S. Ding   +2 more
openaire   +3 more sources

Influence of TPMT and NUDT15 Genetic Polymorphisms on Mercaptopurine Pharmacokinetics in Healthy Volunteers

Genetic Testing and Molecular Biomarkers
Aims: This study aimed to investigate the impact of genetic polymorphisms of thiopurine methyltransferase (TPMT) and NUDT15 on pharmacokinetics profile of mercaptopurine in healthy adults in China. Methods: Blood samples were obtained from 45 healthy adult volunteers who were administered azathioprine.
Qihui Kong, Qiqi Zhang, Di Chen, Jinfang Lou, Jian Zhu, Mingjing Chen, Ting Li   +6 more
openaire   +2 more sources