Results 161 to 170 of about 1,959 (184)

Nudt15-mediated inflammatory signaling contributes to divergent outcomes in leukemogenesis and hematopoiesis

Leukemia
NUDT15 encodes nucleotide triphosphate diphosphatase that is responsible for metabolizing purine analog drugs, and its genetic mutation results in severe side effects from thiopurine therapy. However, the functions of Nudt15 in leukemic stem cells (LSCs) and hematopoietic stem cells (HSCs) remain unknown.
Jiachen Wang, Yu Zhang, Lei Li, Liujiao Wang, Shuainan Sun, Bowu Wang, Yanwen Ge, Zhonghui Zhang   +7 more
openaire   +2 more sources

Severe myelosuppression and alopecia with thiopurine initiation and NUDT15 deficiency

Thiopurines are a class of immunosuppressant and anti-neoplastic agents. They are widely used in the treatment of inflammatory bowel disease, hematological malignancies, and autoimmune diseases, but can cause significant toxicity. Inherited gene mutations are now recognized as independent risk factors for severe adverse drug reactions to thiopurines ...
Annie Wu, Lee Mozessohn, Richard Kim, Jonathan S. Zipursky   +3 more
openaire   +1 more source

Genetic variants in NUDT15 gene their clinical implications in cancer therapy

Drug Metabolism and Personalized Therapy
Abstract Individual variations in the response to thiopurine-based anticancer drugs are influenced by genetic and environmental factors, making it challenging to optimize dosing and minimize toxicity. Among the key genes involved, genetic variations in the nudix hydrolase 15
Yazun, Jarrar, Maria, Ghishan, Fatima, Khirfan, Nancy, Hakooz   +3 more
openaire   +2 more sources

Detection of NUDT15 R139C variants and azathioprine utilization in patients with dermatologic conditions

International Journal of Dermatology, 2023
Kyung B. Chung, Haejune Sung, Do‐Young Kim   +2 more
openaire   +2 more sources

Thiopurine pharmacogenomic landscape in India: TPMT and NUDT15 allele frequencies

Blood
Abstract Thiopurines—such as azathioprine, mercaptopurine, and thioguanine—are commonly used in hematology as immunosuppressants and chemotherapeutic agents. However, they carry a risk of myelosuppression, potentially leading to treatment delays or discontinuation. Genetic variants in TPMT and
Chepsy Philip, Rajdeep Raha, Bani Jolly, Minu Luckose, Aakash Chozakade, Bonnie George, Anupa Jacob, Magdelin Simon, Bobby George, Sudhir Venkatesh, Vinod Scaria   +10 more
openaire   +1 more source

NUDT15: A major determinant of thiopurine sensitivity in Asians

Pediatrics International, 2021
openaire   +2 more sources

NUDT15 Polymorphism in Native American Populations of Brazil

Clinical Pharmacology & Therapeutics, 2019
Guilherme, Suarez-Kurtz, Gisele D, Brisson, Mara H, Hutz, Maria Luiza, Petzl-Erler, Francisco M, Salzano   +4 more
openaire   +2 more sources

Novel risk factor for valganciclovir toxicity—NUDT15 genetic variant

Transplant Infectious Disease, 2022
Ashay Shingare, Nikhil Dhope, Madan M. Bahadur   +2 more
openaire   +2 more sources

NUDT15 Variants Alter Thiopurine-Associated Hematopoietic Toxicity

Cancer Discovery, 2016
Abstract Inactivating NUDT15 polymorphisms are associated with thiopurine intolerance.
openaire   +1 more source

NUDT15 genotype testing in inflammatory bowel disease patients in Australia

Internal Medicine Journal, 2022
Natalie Yu, Jonathan P. Segal, Nik S. Ding   +2 more
openaire   +3 more sources