Results 171 to 180 of about 1,959 (184)

Low NUDT15 expression levels due to biallelic NUDT15 variants and 6-mercaptopurine intolerance

British Journal of Haematology, 2022
Motohiro Kato, Tomoo Osumi, Takako Miyamura   +2 more
exaly  

Increased DNA-incorporated thiopurine metabolite as a possible mechanism for leukocytopenia through cell apoptosis in inflammatory bowel disease patients with NUDT15 mutation

Journal of Gastroenterology, 2021
Hideki Terai, Shintaro Sagami, Taku Kobayashi   +2 more
exaly  

NUDT15 R139C-related thiopurine leukocytopenia is mediated by 6-thioguanine nucleotide-independent mechanism in Japanese patients with inflammatory bowel disease

Journal of Gastroenterology, 2015
Akira Andoh, Atsushi Nishida, Hirotsugu Imaeda   +2 more
exaly  

Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry

Genetics in Medicine, 2019
Jun J Yang, Martin Stanulla, Matthias Schwab   +2 more
exaly  

NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study

Journal of Gastroenterology, 2018
Tomoo Nakagawa, Hisashi Shiga, Atsushi Masamune   +2 more
exaly  

Combined Detection of NUDT15 Variants Could Highly Predict Thiopurine-induced Leukopenia in Chinese Patients with Inflammatory Bowel Disease: A Multicenter Analysis.

Inflammatory Bowel Diseases, 2017
xiang GAO, Kang Chao, Xue-Ding Wang
exaly  

Diagnostic accuracy of NUDT15 gene variants for thiopurine-induced leukopenia: a systematic review and meta-analysis

Pharmacological Research, 2018
Sarah Cargnin, Salvatore Terrazzino, Armando A. Genazzani   +2 more
exaly  

Thiopurine intolerance-causing mutations in NUDT15 induce temperature-dependent destabilization of the catalytic site

Biochimica Et Biophysica Acta - Proteins and Proteomics, 2019
Petr Novák, Petr Man, Aleš Hnízda
exaly  

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Frontiers in Pharmacology, 2019
Heng Xu, Xiaoli Fan, Li Yang
exaly  

NUDT15 p.R139C variant is common and strongly associated with azathioprine-induced early leukopenia and severe alopecia in Korean patients with various neurological diseases

Journal of the Neurological Sciences, 2017
Jin-Sung Park, Jong Kuk Kim, So Young Huh   +2 more
exaly