Results 151 to 160 of about 1,959 (184)

Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity

Proceedings of the National Academy of Sciences of the United States of America, 2020
As a prototype of genomics-guided precision medicine, individualized thiopurine dosing based on pharmacogenetics is a highly effective way to mitigate hematopoietic toxicity of this class of drugs.
Motohiro Kato, Prateek Bhatia, Douglas M Fowler   +2 more
exaly   +2 more sources

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Low NUDT15 expression levels due to biallelic NUDT15 variants and 6‐mercaptopurine intolerance

British Journal of Haematology, 2022
Summary6‐Mercaptopurine (6‐MP) is widely used for the treatment of paediatric leukaemia and lymphoma. Recently, germline variants in the NUDT15 gene have been identified as one of the major genetic causes for 6‐MP–associated adverse effects such as myelosuppression.
Masanori Yoshida, Scott A. Brown, Takaya Moriyama, Rina Nishii, Shin‐ichi Tsujimoto, Yuji Yamada, Kaoru Yoshida, Ryota Shirai, Tomoo Osumi, Tomoyuki Utano, Reiji Fukano, Ko Kudo, Kimiyoshi Sakaguchi, Yuki Arakawa, Katsuyoshi Koh, Masahiro Sekiguchi, Masahiro Sekimizu, Takako Miyamura, Hisashi Ishida, Takeshi Inukai, Daisuke Tomizawa, Nobutaka Kiyokawa, Motohiro Kato, Jun J. Yang   +23 more
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NUDT15 polymorphism in healthy children with Bai nationality in Yunnan of China

Pediatrics International, 2021
AbstractBackgroundThiopurine methyltransferase (TPMT) polymorphism is one of the causes of the toxicity of thiopurines, but this is rarely seen in Asian populations. Rather, the nucleoside diphosphate‐linked X‐component motif 15 (NUDT15) gene is frequently linked to mercaptopurine (MP) intolerance and myelotoxicity in children with acute lymphoblastic ...
Gangling Pu, Yali Wang, Shaoqin Duan, Jingpei Chen, Chunhui Yang, Tingting Cui, Chunlian Fang, Yan Zhou, Han Zhang, Xin Tian   +9 more
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NUDT15 genotype distributions in the Korean population

Pharmacogenetics and Genomics, 2017
Thiopurines have a narrow therapeutic range because of frequent toxicity (i.e. marrow suppression), which is only partly explained by TPMT genetic polymorphisms, especially within Asian populations. Recent studies have identified NUDT15 variation as another important factor affecting thiopurine metabolism.
Hyoung-Tae, Kim, Rihwa, Choi, Hong-Hee, Won, Yon Ho, Choe, Ben, Kang, Kiwuk, Lee, Hong Hoe, Koo, Keon Hee, Yoo, Young-Ho, Kim, Soo-Youn, Lee   +9 more
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Cost-effectiveness analysis of pretreatment screening for NUDT15 defective alleles

Pharmacogenetics and Genomics, 2020
Background Nucleotide triphosphate diphosphatase (NUDT15) genetic testing in addition to thiopurine methyl transferase (TPMT) is recommended to reduce the incidence of adverse severe myelotoxicity episodes induced by thiopurines. Objective We assessed the cost-effectiveness ratio of
Kevin, Zarca, Albain, Chansavang, Marie-Anne, Loriot, Isabelle, Durand-Zaleski, Nicolas, Pallet   +4 more
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Preemptive NUDT15 genotyping: redefining the management of patients with thiopurine-induced toxicity

Drug Metabolism and Personalized Therapy, 2018
AbstractBackground:Thiopurine methyltransferase (TPMT) gene variants have achieved limited success in predicting the outcome of thiopurine therapy, which shows wide inter-individual variations. The literature indicates a strong association between theNUDT15gene variant and thiopurine-induced toxicity in Asian patients.
Tester F Ashavaid, Devendra Desai, Swarup Shah   +2 more
exaly   +3 more sources

Pharmacogenomics of thiopurines: distribution of TPMT and NUDT15 polymorphisms in the Brazilian Amazon

Pharmacogenetics and Genomics, 2020
Reduced function alleles in the TPMT and NUDT15 genes are risk factors for thiopurine toxicity. This study evaluated the influence of Native ancestry on the distribution of TPMT (rs1142345, rs1800460 and rs1800462) and NUDT15 (rs116855232) polymorphisms and compound metabolic phenotypes in 128 healthy males from the Brazilian Amazon.
Guilherme Motta Antunes, Ferreira, Anna Beatriz, Ribeiro Elias, Joabi, Nascimento, Wuelton Marcelo, Monteiro, Gisely Cardoso, Melo, Djane Clarys, Baia-da-Silva, Marcus Vinícius Guimarães, Lacerda, Guilherme, Suarez-Kurtz   +7 more
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Comprehensive characterization of pharmacogenetic variants in TPMT and NUDT15 in children with acute lymphoblastic leukemia

Pharmacogenetics and Genomics, 2021
Thiopurines [e.g. 6-mercaptopurine (6MP)] are essential for the cure of acute lymphoblastic leukemia (ALL) but can cause dose-limiting hematopoietic toxicity. Germline variants in drug-metabolizing enzyme genes TPMT and NUDT15 have been linked to the risk of thiopurine toxicity.
Takaya, Moriyama, Wenjian, Yang, Colton, Smith, Ching-Hon, Pui, William E, Evans, Mary V, Relling, Smita, Bhatia, Jun J, Yang   +7 more
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Childhood acute lymphoblastic leukemia mercaptopurine intolerance is associated with NUDT15 variants

Pediatric Research, 2020
Mercaptopurine-induced neutropenia can interrupt chemotherapy and expose patients to infection during childhood acute lymphoblastic leukemia (ALL) treatment. Previously, six candidate gene variants associated with mercaptopurine intolerance were reported.
Der-Shiun, Wang, Chih-Hsiang, Yu, Chien-Yu, Lin, Ya-Hsuan, Chang, Kai-Hsin, Lin, Dong-Tsamn, Lin, Shiann-Tarng, Jou, Meng-Yao, Lu, Hsiu-Hao, Chang, Shu-Wha, Lin, Hsuan-Yu, Chen, Yung-Li, Yang   +11 more
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Influence of TPMT and NUDT15 Genetic Polymorphisms on Mercaptopurine Pharmacokinetics in Healthy Volunteers

Genetic Testing and Molecular Biomarkers
Aims: This study aimed to investigate the impact of genetic polymorphisms of thiopurine methyltransferase (TPMT) and NUDT15 on pharmacokinetics profile of mercaptopurine in healthy adults in China. Methods: Blood samples were obtained from 45 healthy adult volunteers who were administered azathioprine.
Ting Li
exaly   +3 more sources