Results 151 to 160 of about 2,479 (192)

Azathioprine-Associated Acute Pancreatitis Followed by a Probable Autoimmune Hepatitis Flare After Thiopurine Withdrawal: A Case Report. [PDF]

Cureus
Marfo E, Oladoyin V, Liu J.
europepmc   +1 more source

Frequency of thiopurine methyltransferase variants and exploratory predictors of azathioprine-induced leukopenia in Saudi patients with inflammatory bowel disease. [PDF]

Saudi J Gastroenterol
Meeralam YK, Al-Zanbagi AB, Al Saedi M, Sulaimani M, Basfar A, Almutawa W, Albelewi SH, Shariff MK.   +7 more
europepmc   +1 more source

The evolving landscape of pharmacogenomics: Current achievements and future directions. [PDF]

Pharmacol Rev
Lauschke VM, Ingelman-Sundberg M.
europepmc   +1 more source

Efficacy and safety of azathioprine in patients with Cronkhite-Canada syndrome: a case series from Peking Union Medical College Hospital. [PDF]

BMC Pharmacol Toxicol
Xu Q, Jin L, Ou C, Xu T, Yang Z, Zhang R, Liu S, Yan X, Ruan G, Li J, Li J.   +10 more
europepmc   +1 more source

Perspectives in clinical research on Azathioprine for steroid-dependent ulcerative colitis. [PDF]

Front Med (Lausanne)
Qu YT, Ding JY, Pan W, Liu FR, Dong AL.
europepmc   +1 more source

Landscape of TPMT and NUDT15 Pharmacogenetic Variation in a Cohort of Canadian Pediatric Inflammatory Bowel Disease Patients. [PDF]

Inflamm Bowel Dis
Kennedy AM, Griffiths AM, Muise AM, Walters TD, Ricciuto A, Huynh HQ, Wine E, Jacobson K, Lawrence S, Carman N, Mack DR, deBruyn JC, Otley AR, Deslandres C, El-Matary W, Zachos M, Benchimol EI, Critch J, Schneider R, Crowley E, Li M, Warner N, McGovern DPB, Li D, Haritunians T, Rudin S, Cohn I.   +26 more
europepmc   +1 more source

Targeted Protein Degradation of NUDT5 Reveals an Unexpected Non-Enzymatic Role in 6-Thioguanine-Mediated Toxicity

Marques AMC, Bauer LG, Nguyen T, Orta AG, Venne J, Cheng L, Balikci E, Tivon B, London N, Kubicek S, Huber KVM.   +10 more
europepmc   +1 more source

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity [PDF]

Nature Genetics, 2016
Widely used as anticancer and immunosuppressive agents, thiopurines have narrow therapeutic indices owing to frequent toxicities, partly explained by TPMT genetic polymorphisms. Recent studies identified germline NUDT15 variation as another critical determinant of thiopurine intolerance, but the underlying molecular mechanisms and the clinical ...
Takaya Moriyama, Wenjian Yang, Xujie Zhao   +2 more
exaly   +4 more sources

NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir [PDF]

Cell Chemical Biology, 2021
Ganciclovir (GCV) is the first-line therapy against human cytomegalovirus (HCMV), a widespread infection that is particularly dangerous for immunodeficient individuals. Closely resembling deoxyguanosine triphosphate, the tri-phosphorylated metabolite of GCV (GCV-TP) is preferentially incorporated by the viral DNA polymerase, thereby terminating chain ...
Si Min Zhang, Daniel Rehling, Ann-Sofie Jemth   +2 more
exaly   +3 more sources