Results 141 to 150 of about 1,959 (184)

Influence of xanthine oxidase and inosine monophosphate dehydrogenase polymorphisms on 6-mercaptopurine treatment response in pediatric acute lymphoblastic leukemia. [PDF]

Sci Rep
Sabirova Z, Boucetta MTE, Bensouyad RR, Gagné V, Théorêt Y, Nava T, Leclerc JM, Laverdière C, Sinnett D, Tran TH, Krajinovic M.   +10 more
europepmc   +1 more source

Addressing genetic diversity and health inequities: RELIVAF's proposal for Latin American pharmacogenomic guidelines. [PDF]

Front Pharmacol
Quiñones LA, Martínez MF, Vargas R, Cerpa LC, López-Cortés A, González-Martínez F, Fonseca D, Duconge J, Varela NM, Lares-Asseff I, Redal MA, Esperón P, Ríos-Santos F, Rendón AL, Serrano R, Ortega E, Sullón-Dextre L, Sanchez E, Arias ML, Remírez D, Morales A.   +20 more
europepmc   +1 more source

Clinical Utility and Cost-Effectiveness of Pretreatment NUDT15 Pharmacogenetic Testing to Prevent Thiopurine-Induced Myelosuppression: A Genotype-First Reverse Phenotyping Cohort Study Within the UK NIHR Inflammatory Bowel Disease Bioresource. [PDF]

Aliment Pharmacol Ther
Roberts C, Peters J, Sazonvos A, Goodman N, Sharip M, Smith R, Bishara M, Bewshea C, Lin S, Chanchlani N, Hodges P, Badrulhisham F, Saifuddin A, Carlson S, Centritto A, Marley A, Saad M, Sethi-Aora K, White L, Abdelmeguid A, Pele L, Sebastian S, Selinger C, Irving P, Fachal L, Walker G, Palmer R, Kennedy N, Houghton J, Doona M, Lamb C, Hyde C, Parkes M, Goodhand J, Ahmad T.   +34 more
europepmc   +1 more source

Associations of Nucleoside Diphosphate-Linked Moiety X-Type Motif 15 Variants With Neutropenia During Antiviral Therapy for Cytomegalovirus Disease in Pediatric Liver Transplant Recipients. [PDF]

Transpl Infect Dis
Iwata KI, Torii Y, Fukuda Y, Haruta K, Yamaguchi M, Suzuki T, Ogura Y, Kawada JI.   +7 more
europepmc   +1 more source

Pharmacogenomic Calling From Whole-Exome Sequencing in the Taiwanese Population-A Real-World Experience. [PDF]

Mol Genet Genomic Med
Lin HH, Tsai MM, Chen HA, Hsu RH, Lin YS, Lin YL, Hsu C, Chien YH, Hwu WL, Lee NC.   +9 more
europepmc   +1 more source

Importance of NUDT15 Polymorphisms in Thiopurine Treatments [PDF]

Journal of Personalized Medicine, 2021
Thiopurines, mercaptopurine, and azathioprine are used as immunosuppressants in the treatments of inflammatory bowel disease, rheumatoid arthritis, and organ transplantation and as chemotherapeutic drugs for the treatment of acute leukemia and chronic ...
Yoshiro Saito, Yoichi Tanaka
exaly   +4 more sources

NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir [PDF]

Cell Chemical Biology, 2021
Ganciclovir (GCV) is the first-line therapy against human cytomegalovirus (HCMV), a widespread infection that is particularly dangerous for immunodeficient individuals.
Si Min Zhang, Cecilia Söderberg-Nauclér, Brent Page   +2 more
exaly   +5 more sources

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NUDT15: A bench to bedside success story

Clinical Biochemistry, 2021
Recently, the enzyme nudix hydrolase 15 (NUDT15) has been identified as an additional component of the thiopurine metabolism pathway. NUDT15 (also known as MTH2) catalyzes the dephosphorylation of 6-thioguanosine triphosphate (6-TGTP) and 6-thio-deoxyguanosine triphosphate (6-TdGTP), which is the active metabolite of thiopurine medications.
Ann M Moyer
exaly   +3 more sources

Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity [PDF]

Journal of Biological Chemistry, 2021
The enzyme NUDT15 efficiently hydrolyses the active metabolites of thiopurine drugs, which are routinely used for treating cancer and inflammatory diseases.
Si Min Zhang, Jun J Yang, Sean G Rudd
exaly   +2 more sources