Analytical Validation of Variants to Aid in Genotype-Guided Therapy for Oncology [PDF]
, 2019 The Clinical Laboratory Improvement Amendments (CLIA) of 1988 requires that pharmacogenetic genotyping methods need to be established according to technical standards and laboratory practice guidelines before testing can be offered to patients.
Kiel, Patrick J. +7 more
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PLoS ONE, 2020 IntroductionThe nudix hydrolase 15 (NUDT15) gene acts in the metabolism of thiopurine, by catabolizing its active metabolite thioguanosine triphosphate into its inactivated form, thioguanosine monophosphate.
Juliana Carla Gomes Rodrigues +19 more
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Pharmacogenetics-based personalized treatment in patients with inflammatory bowel disease: A review [PDF]
Precision and Future Medicine, 2021 The development of treatment options has revolutionized the prognosis of inflammatory bowel disease (IBD). However, a particular group of patients still experience therapeutic failure or drug side effects.
Ji Young Chang, Jae Hee Cheon
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Expression of oxidative stress and antioxidant defense genes in the kidney of inbred mice after intestinal ischemia and reperfusion [PDF]
, 2013 PURPOSE: To determine the gene expressions profile related to the oxidative stress and the antioxidant response in the kidneys of mice subjected to intestinal ischemia and reperfusion.
Bertoletto, Paulo Roberto +6 more
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Genomic medicine in inflammatory bowel disease [PDF]
, 2020 Inflammatory bowel disease (IBD) is a term for two conditions (Crohn’s disease [CD] and ulcerative colitis [UC]) that are characterised by chronic inflammation of the gastrointestinal tract.
Voskuil, Michiel
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6-methylmercaptopurine-induced leukocytopenia during thiopurine therapy in inflammatory bowel disease patients [PDF]
, 2017 Background and Aim: Thiopurines have a favorable benefit–risk ratio in the treatment of inflammatory bowel disease. A feared adverse event of thiopurine therapy is myelotoxicity, mostly occurring due to toxic concentrations of the pharmacologically ...
Bodegraven, A.A. (Ad) van +9 more
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NUDT15: a novel player in thiopurine metabolism
Journal of Gastrointestinal and Liver Diseases, 2016 .
Meijer, Berrie +2 more
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Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion. [PDF]
, 2016 Estrogen receptor (ER)-negative cancers have a poor prognosis, and few targeted therapies are available for their treatment. Our previous analyses have identified potential kinase targets critical for the growth of ER-negative, progesterone receptor (PR)-
Brown, Powel H +13 more
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Azathioprine dose tailoring based on pharmacogenetic information: Insights of clinical implementation [PDF]
, 2023 Supplementary data associated with this article can be found in the online version at doi:10.1016/j.biopha.2023.115706Azathioprine is commonly used as an immunosuppressive antimetabolite in the treatment of acute lymphoblastic leukemia, autoimmune ...
Cabeza Barrera, José +7 more
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Second Korean Guideline for the Management of Ulcerative Colitis [PDF]
, 2017 Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by a relapsing and remitting course. The direct and indirect costs of the treatment of UC are high, and the quality of life of patients is reduced, especially during ...
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