Results 71 to 80 of about 37,468 (260)
Advanced Materials, EarlyView.Inspired by viral entry mechanisms, the FUSION assay enables autonomous detection of respiratory viruses via membrane fusion–triggered CRISPR‐Cas13a activation. VEACON selectively fuses with fusion‐competent viruses, triggering fluorescence within confined vesicles.
Jae Chul Park +15 more
wiley +1 more source
OGA heterozygosity suppresses intestinal tumorigenesis in Apc min/+ mice [PDF]
, 2014 Emerging evidence suggests that aberrant O-GlcNAcylation is associated with tumorigenesis. Many oncogenic factors are O-GlcNAcylated, which modulates their functions.
A Sveen +24 more
core +1 more source
Molecular Interrogation to Crack the Case of O‐GlcNAc [PDF]
Chemistry – A European Journal, 2020 AbstractThe O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) modification, termed O‐GlcNAcylation, is an essential and dynamic post‐translational modification in cells. O‐GlcNAc transferase (OGT) installs this modification on serine and threonine residues, whereas O‐GlcNAcase (OGA) hydrolyzes it.
Arielis Estevez +3 more
openaire +2 more sources
Interaction between O-GlcNAc modification and tyrosine phosphorylation of prohibitin: implication for a novel binary switch. [PDF]
PLoS ONE, 2009 Prohibitin (PHB or PHB1) is an evolutionarily conserved, multifunctional protein which is present in various cellular compartments including the plasma membrane. However, mechanisms involved in various functions of PHB are not fully explored yet. Here we
Sudharsana R Ande +2 more
doaj +1 more source
O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer
Advanced Science, EarlyView.This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu +10 more
wiley +1 more source
Glycosylation in the thyroid gland : vital aspects of glycoprotein function in thyrocyte physiology and thyroid disorders [PDF]
, 2018 The key proteins responsible for hormone synthesis in the thyroid are glycosylated. Oligosaccharides strongly affect the function of glycosylated proteins.
Ewa Pocheć +2 more
core +1 more source
Mapping the O-GlcNAc Modified Proteome: Applications for Health and Disease
Frontiers in Molecular Biosciences, 2022 O-GlcNAc is a pleotropic, enigmatic post-translational modification (PTM). This PTM modifies thousands of proteins differentially across tissue types and regulates diverse cellular signaling processes. O-GlcNAc is implicated in numerous diseases, and the
Rajan A. Burt +6 more
doaj +1 more source
Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems
Advanced Science, EarlyView.A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller +9 more
wiley +1 more source
Solving the mystery of human sleep schedules one mutation at a time. [PDF]
, 2013 Sleep behavior remains one of the most enigmatic areas of life. The unanswered questions range from "why do we sleep?" to "how we can improve sleep in today's society?" Identification of mutations responsible for altered circadian regulation of human ...
Fu, Ying-Hui +2 more
core +1 more source
Respiratory Research, 2023 Background The level of linked N-acetylglucosamine (O-GlcNAc) has been proved to be a sensor of cell state, but its relationship with hyperoxia-induced alveolar type 2 epithelial cells injure and bronchopulmonary dysplasia (BPD) has not been clarified ...
Yu Xuefei +4 more
doaj +1 more source