Results 81 to 90 of about 37,468 (260)

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

O‐GlcNAc modification of CaMKIV

The FASEB Journal, 2008
Similar to phosphorylation, O‐GlcNAcylation (or simply GlcNAcylation) is an abundant, dynamic, and inducible post‐translational modification. In some cases, GlcNAcylation and phosphorylation occur at the same or adjacent sites, modulating each other.
Wagner Barbosa Dias, Win Cheung, Zihao Wang, Gerald Hart   +3 more
openaire   +1 more source

O-GlcNAcylation: an important post-translational modification and a potential therapeutic target for cancer therapy

Molecular Medicine, 2022
O-linked β-d-N-acetylglucosamine (O-GlcNAc) is an important post-translational modification of serine or threonine residues on thousands of proteins in the nucleus and cytoplasm of all animals and plants.
Qingsong Lu, Xiaozhen Zhang, Tingbo Liang, Xueli Bai   +3 more
doaj   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy [PDF]

, 2016
Sustained glucose and glutamine transport are essential for activated T lymphocytes to support ATP and macromolecule biosynthesis. We now show that glutamine and glucose also fuel an indispensible dynamic regulation of intracellular protein O ...
A Boudil, A Golks, A Suzuki, A Wolfer, AJ Marko, AL Doedens, AN Macintyre, AP Kelly, C-H Chang, C-Y Huang, Daan M F van Aalten, DC Turnock, DK Finlay, Doreen A Cantrell, EL Carr, EL Pearce, FV Rao, G Balciunaite, GC Preston, GW Hart, GW Hart, HC Dorfmueller, HJ Hinton, J Rolf, J Zhang, J Zhong, Katarzyna M Grzes, KP Kearse, Linda V Sinclair, LJ Beverly, LV Sinclair, M Ciofani, M Ciofani, M Dose, M Dose, M Nakaya, Mahima Swamy, MP Mycko, MR Bond, N O'Donnell, NJ MacIver, P Ramakrishnan, P-C Ho, R Shafi, R Wang, Sebastian Damerow, Shalini Pathak, TJ Hagenbeek, TJ Hagenbeek, TM Gloster, TM Schmitt, TY Chou, U Koch, W Liao, Z Wang   +54 more
core   +3 more sources

O-GlcNAc-ylation in the Nuclear Pore Complex [PDF]

Cellular and Molecular Bioengineering, 2016
O-GlcNAc-ylation is the post-translational addition of an O-linked β-N-acetylglucosamine to the serine and threonine residues of thousands of proteins in eukaryotic cells. Specifically, half of the thirty different types of protein components in the nuclear pore complex (NPC) are modified by O-GlcNAc, of which the majority are intrinsically disordered ...
Andrew, Ruba, Weidong, Yang
openaire   +2 more sources

Sex alters thyroid hormone’s effect on protein O-GlcNAcylation in the aged mouse heart

BMC Molecular and Cell Biology
Background The aging heart undergoes physiological changes, many of which are sex dependent and encompass differential responses to cardiac stress. However, much about the molecular changes that occur within the aging heart is still unknown.
Aaron K. Olson, Wei Zhong Zhu, Dolena Ledee   +2 more
doaj   +1 more source

Identification of O-GlcNAc modification targets in mouse retinal pericytes: implication of p53 in pathogenesis of diabetic retinopathy.

PLoS ONE, 2014
Hyperglycemia is the primary cause of the majority of diabetes complications, including diabetic retinopathy (DR). Hyperglycemic conditions have a detrimental effect on many tissues and cell types, especially the retinal vascular cells including early ...
Zafer Gurel, Balyn W Zaro, Matthew R Pratt, Nader Sheibani   +3 more
doaj   +1 more source

Developmental regulation of protein O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in mammalian brain. [PDF]

PLoS ONE, 2012
O-GlcNAcylation is a common posttranslational modification of nucleocytoplasmic proteins by β-N-acetylglucosamine (GlcNAc). The dynamic addition and removal of O-GlcNAc groups to and from proteins are catalyzed by O-linked N-acetylglucosamine transferase
Ying Liu, Xiaojing Li, Yang Yu, Jianhua Shi, Zhihou Liang, Xiaoqin Run, Yi Li, Chun-ling Dai, Inge Grundke-Iqbal, Khalid Iqbal, Fei Liu, Cheng-Xin Gong   +11 more
doaj   +1 more source

Nutrient sensitive protein O -GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis

Life Science Alliance, 2022
Maternal hyperglycemia and elevated O-GlcNAc levels perturb promoter bivalency and lead to transcriptional up-regulation of neurogenic transcription factors during embryonic neurogenesis.
Shama Parween, Thilina T Alawathugoda, Ashok D Prabakaran, S Thameem Dheen, Randall H Morse, Bright Starling Emerald, Suraiya A Ansari   +6 more
doaj   +1 more source