Results 101 to 110 of about 37,468 (260)

Cardiac transcription factor Nkx2.5 is downregulated under excessive O-GlcNAcylation condition. [PDF]

PLoS ONE, 2012
Post-translational modification of proteins with O-linked N-acetylglucosamine (O-GlcNAc) is linked the development of diabetic cardiomyopathy. We investigated whether Nkx2.5 protein, a cardiac transcription factor, is regulated by O-GlcNAc.
Hoe Suk Kim, Ji Soo Woo, Hyun Jung Joo, Woo Kyung Moon   +3 more
doaj   +1 more source

O-GlcNAc Modification Is an Endogenous Inhibitor of the Proteasome [PDF]

Cell, 2003
The ubiquitin proteasome system classically selects its substrates for degradation by tagging them with ubiquitin. Here, we describe another means of controlling proteasome function in a global manner. The 26S proteasome can be inhibited by modification with the enzyme, O-GlcNAc transferase (OGT). This reversible modification of the proteasome inhibits
Zhang, Fengxue, Su, Kaihong, Yang, Xiaoyong, Bowe, Damon B., Paterson, Andrew J., Kudlow, Jeffrey E.   +5 more
openaire   +2 more sources

Multimodal Chromatography in the Downstream Processing of mAb‐Based Products: Mechanisms, Strategies, and Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Multimodal chromatography has emerged as a powerful tool for the purification of monoclonal antibodies (mAbs) and their derivatives—including antibody fragments (Fabs), Fc‐fusions, bispecific (BsAb), and antibody–drug conjugates (ADCs)—offering enhanced selectivity through the integration of ionic, hydrophobic, hydrogen‐bonding, and π–π ...
Amin Javidanbardan, Marco P․ C․ Marques, Ana M. Azevedo, Daniel G. Bracewell, Stephen Goldrick   +4 more
wiley   +1 more source

A Quantum Mechanics / Molecular Mechanics Study of the Protein-Ligand Interaction of two potent inhibitors of human O-GlcNAcase: PUGNAc and NAG-thiazoline [PDF]

, 2008
O-glycoprotein 2-acetamino-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase) hydrolyzes 2-acetamido-2-deoxy-β-D-glucopyranose (O-GlcNAc) residues of serine/threonine residues of modified proteins.
Kanaan Izquierdo, Natalia, Lameira, Jerônimo, Martí Forés, Sergio, Moliner, Vicent, Nahum Alves, Cláudio, Tuñón, Iñaki   +5 more
core   +3 more sources

Chemical Arsenal for the Study of O-GlcNAc

Molecules, 2011
The concepts of both protein glycosylation and cellular signaling have been influenced by O-linked-β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) on the hydroxyl group of serine or threonine residues. Unlike conventional protein glycosylation, O-GlcNAcylation is localized in the nucleocytoplasm and its cycling is a dynamic process that
openaire   +3 more sources

Synthesis, -GlcNAc Modification, and Potential Applications of -Acetylglucosamine Derivatives

Natural Product Communications
N-acetylglucosamine (GlcNAc) is a versatile monosaccharide with broad applications in medicine, food, and cosmetics due to its antimicrobial, antioxidant, and anti-tumor properties. Efficient synthesis methods for GlcNAc remain a prominent research focus.
Boyuan Wang, Jiale Mao, Yihan Ma, Ming Ke, Wei Zhao, Usman Dawood Butt, Shuang Liu, Xiaoqin Zhang, Zunjing Zhang   +8 more
doaj   +1 more source

DeepO-GlcNAc: a web server for prediction of protein O-GlcNAcylation sites using deep learning combined with attention mechanism

Frontiers in Cell and Developmental Biology
IntroductionProtein O-GlcNAcylation is a dynamic post-translational modification involved in major cellular processes and associated with many human diseases.
Liyuan Zhang, Tingzhi Deng, Tingzhi Deng, Shuijing Pan, Minghui Zhang, Yusen Zhang, Chunhua Yang, Xiaoyong Yang, Geng Tian, Jia Mi   +9 more
doaj   +1 more source

RING1B O-GlcNAcylation regulates gene targeting of polycomb repressive complex 1 in human embryonic stem cells

Stem Cell Research, 2015
O-linked-N-acetylglucosamine (O-GlcNAc) post-translationally modifies and regulates thousands of proteins involved in various cellular mechanisms. Recently, O-GlcNAc has been linked to human embryonic stem cells (hESC) differentiation, however the ...
Julien Jean Pierre Maury, Chadi A. EL Farran, Daniel Ng, Yuin-Han Loh, Xuezhi Bi, Muriel Bardor, Andre Boon-Hwa Choo   +6 more
doaj   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Identification of the Plasticity-Relevant Fucose-α(1−2)-Galactose Proteome from the Mouse Olfactory Bulb [PDF]

, 2009
Fucose-α(1−2)-galactose [Fucα(1−2)Gal] sugars have been implicated in the molecular mechanisms that underlie neuronal development, learning, and memory. However, an understanding of their precise roles has been hampered by a lack of information regarding
Domino, Steven E., Ficarro, Scott B., Hsieh-Wilson, Linda C., Krishnamurthy, Chithra, Murrey, Heather E., Peters, Eric C.   +5 more
core   +4 more sources