Results 121 to 130 of about 20,888 (214)

Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity [PDF]

, 2015
Liver X receptor (LXR)α and LXRβ play key roles in hepatic de novo lipogenesis through their regulation of lipogenic genes, including sterol regulatory element-binding protein (SREBP)-1c and carbohydrate responsive element-binding protein (ChREBP).
Bindesbøll, Christian, Fan, Qiong, Grønning-Wang, Line M, MacPherson, Laura, Mandrup, Susanne, Matthews, Jason, Nebb, Hilde I, Nørgaard, Rikke C, Pedersen, Thomas Å, Ruan, Hai-Bin, Steffensen, Knut R, Wu, Jing, Yang, Xiaoyong   +12 more
core   +2 more sources

Systematic Chemoenzymatic Synthesis of O-Sulfated Sialyl Lewis x Antigens. [PDF]

, 2015
O-Sulfated sialyl Lewis x antigens play important roles in nature. However, due to their structural complexity, they are not readily accessible by either chemical or enzymatic synthetic processes.
Chen, Xi, Kenyond, Nicholas J, Li, Yanhong, Louie, Angelique Y, Muthana, Musleh M, Santra, Abhishek, Tasnima, Nova, Yu, Hai, Zeng, Jie   +8 more
core   +1 more source

Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice. [PDF]

, 2019
Hepcidin is a liver-derived peptide hormone that controls systemic iron homeostasis. Its expression is regulated by the bone morphogenetic protein 6 (BMP6)/SMAD1/5/8 pathway and by the proinflammatory cytokine interleukin 6 (IL6).
Anower-E-Khuda, Ferdous, Arosio, Paolo, Asperti, Michela, Denardo, Andrea, Esko, Jeffrey D, Gordts, Philip LSM, Gryzik, Magdalena, Poli, Maura, Ruzzenenti, Paola   +8 more
core  

The roles of OGT and its mechanisms in cancer

Cell & Bioscience
O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a common and important post-translational modification (PTM) linking O-linked β-N-acetylglucosamine (O-GlcNAc) to serine and threonine residues in proteins.
Xin Liu, Jing Wang, Yaoxian Xiang, Kangjie Wang, Dong Yan, Yingying Tong   +5 more
doaj   +1 more source

The effect of peri-conception hyperglycaemia and the involvement of the hexosamine biosynthesis pathway in mediating oocyte and embryo developmental competence [PDF]

, 2014
The environment that the oocyte is exposed to during the peri-conception period can have a significant impact on oocyte developmental competence (the ability of the oocyte to support fertilisation and subsequent embryo development) and the long-term ...
Akimoto, Akimoto, Ali, Alvino, Anderson, Arias, Arias, Arnot, Assidi, Baccetti, Badet, Banfalvi, Becerra, Bell, Bergh, Biggers, Boney, Brownlee, Buse, Butkinaree, Caixeta, Carrette, Casson, Cetica, Chalepakis, Chang, Chatot, Chatot, Chen, Cheng, Cheng, Chou, Chou, Chou, Colton, Colton, Comer, Comer, Copeland, Cornblath, Dalton, Datta, DeHaven, Diamond, Dokras, Dong, Downs, Downs, Downs, Downs, Du, Dunne, Dunning, El Shourbagy, El-Sayed, Eppig, Eppig, Farrell, Fleming, Frank, Frank, Frolova, Funahashi, Fuster, Gao, Gardner, Greene, Grondahl, Guerin, Gupta, Gutnisky, Haltiwanger, Haltiwanger, Haltiwanger, Harris, Hart, Hashimoto, Hedderson, Hendryx, Holing, Holt, Horal, Jimenez, Johnson, Julenius, Jungheim, Jungheim, Kang, Kanji, Kelly, Kim, Kreppel, Kreppel, Kreppel, Kumar, Lapolla, Lapolla, Lazarus, Lea, Leese, Leese, Lefebvre, Lubas, Lubas, Luciano, Marquard, Marshall, Marshall, Marshall, McClain, Medina, Merriman, Metwally, Middleton, Mikkelsen, Milewski, Miller, Mills, Mills, Moley, Moley, Moley, Moley, Monauni, Nandi, Nataprawira, Nelkin, Nelson, Nishimoto, Norman, O'Brien, Oh, Oki, Pantaleon, Pantaleon, Park, Parker, Patti, Pearson, Petersen, Purcell, Ratchford, Ray, Reece, Rich-Edwards, Roberts, Robker, Robker, Rolo, Roquemore, Roquemore, Runft, Russell, Sadler, Salustri, Santos, Sayeski, Sayeski, Schaefer, Schelbach, Schelbach, Seshiah, Shafi, Silverman, Slawson, Slawson, Slawson, Steeves, Stothard, Sturmey, Suhonen, Sutton, Sutton-McDowall, Sutton-McDowall, Sutton-McDowall, Sutton-McDowall, Sutton-McDowall, Tamassia, Tanghe, The Jackson Laboratory, Thompson, Thomson, Torres, Tsai, Uldry, Unwin, Van Blerkom, Van den Steen, Virkamaki, Vosseller, Vosseller, Wang, Wang, Wang, Wang, Webb, Wells, Wells, Wells, Whelan, Wilkinson, Williams, Wittmaack, Wongsrikeao, Woolford, Wyman, Xu, Yang, Yang, Yang, Zachara, Zachara, Zachara, Zhang, Zhang, Zhou   +215 more
core   +1 more source

System-based proteomic and metabonomic analysis of the Df(16)A+/- mouse identifies potential miR-185 targets and molecular pathway alterations [PDF]

, 2017
Deletions on chromosome 22q11.2 are a strong genetic risk factor for development of schizophrenia and cognitive dysfunction. We employed shotgun liquid chromatography-mass spectrometry (LC-MS) proteomic and metabonomic profiling approaches on prefrontal ...
Bahn, S. (Sabine), Gogos, J.A., Guest, P.C. (Paul), Holmes, E., Karayiorgou, M., Want, E.J. (Elizabeth J.), Wesseling, H. (Hendrik), Xu, B. (B.)   +7 more
core   +2 more sources

Synthesis of \u3cem\u3eN\u3c/em\u3e-Acetyl-ᴅ-quinovosamine in \u3cem\u3eRhizobium etli\u3c/em\u3e CE3 is Completed After Its 4-keto-precursor is Linked to a Carrier Lipid [PDF]

, 2017
Bacterial O-antigens are synthesized on lipid carriers before being transferred to lipopolysaccharide core structures. Rhizobium etli CE3 lipopolysaccharide is a model for understanding O-antigen biological function.
Li, Tiezheng, Noel, K. Dale
core   +1 more source

GALNT2 as a novel modulator of adipogenesis and adipocyte insulin signaling [PDF]

, 2019
Background/objectives: A better understanding of adipose tissue biology is crucial to tackle insulin resistance and eventually coronary heart disease and diabetes, leading causes of morbidity and mortality worldwide.
Antonucci, A., De Bonis, Maria Caterina, Di Paola, R., Mangiacotti, D., Marucci, A., Scarale, M. G., Trischitta, V.   +6 more
core   +1 more source

Functional genomic profiling of O-GlcNAc reveals its context-specific interplay with RNA polymerase II

Genome Biology
Background How reversible glycosylation of DNA-bound proteins acts on transcription remains scarcely understood. O-linked β-N-acetylglucosamine (O-GlcNAc) is the only known form of glycosylation modifying nuclear proteins, including RNA polymerase II ...
Sofia Rucli, Nicolas Descostes, Yulia Ermakova, Urvashi Chitnavis, Jeanne Couturier, Ana Boskovic, Matthieu Boulard   +6 more
doaj   +1 more source

O-GlcNAc cycling in neuroinflammation: From molecular mechanisms and therapeutic perspectives

Neurobiology of Disease
O-GlcNAcylation is a dynamic post-translational modification that regulates diverse cellular processes by modifying nuclear and cytoplasmic proteins in response to metabolic cues.
Chanhaeng Lee, Sang-Min Kim, Dong Yeol Kim, Inn-Oc Han   +3 more
doaj   +1 more source