Results 111 to 120 of about 20,888 (214)

The Critical Role of GALNTs‐Regulated O‐GalNAc Glycosylation in Cancer Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The GALNT family initiates mucin‐type O‐GalNAc glycosylation in the Golgi apparatus and how regulatory mechanisms, including GALNT relocalization and microRNA control, modulate this process. Dysregulated O‐GalNAc glycosylation alters key cellular behaviors and promotes cancer malignancy, highlighting its relevance to tumor progression as well as its ...
Jiahao Liu, Sihan Wu, Ge Zhang, Jiehan Li, Yuhan Yin, Aman Uiiah, Sanfei Peng, Yang Fu   +7 more
wiley   +1 more source

Regulation and clinical significance of O-GlcNAc transferase in cancer

Oncotarget, 2018
// Xinling Zhang 1 , Yuchao Gu 2 , Wengong Yu 2 and Hui Liang 1 1 The Institute of Human Nutrition, Medical College of Qingdao University, Qingdao 266021, China 2 Key Laboratory of Marine Drugs, Chinese Ministry of Education, Key Laboratory of Glycoscience and Glycotechnology of Shandong Province; School of Medicine and Pharmacy, Ocean ...
Xinling Zhang, Yuchao Gu, Wengong Yu, Hui Liang   +3 more
openaire   +2 more sources

T Cell O‐GlcNAcylation Increases in Patients With Allergic Rhinitis After the Natural Pollen Season

Clinical &Experimental Allergy, EarlyView.
Eduardo I. Cardenas, Maryam Jafari, Emma Nilsson, Agnetha Karlsson, Marianne Petro, Monika Ezerskyte, Ola Winqvist, Lars Olaf Cardell   +7 more
wiley   +1 more source

Synthesis of Polyhydroxylated Pyrrolidinyl Analogs of Sugar Nucleotides. Experimental and Computational Studies on Their Interactions With GalNAC‐T's

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
A multidisciplinary approach based on organic synthesis supported by quantum mechanical calculations, efficient phosphorylation methods, affinity studies using conventional techniques and saturation transfer difference nuclear magnetic resonance, together with molecular dynamics simulations, has enabled the preparation of nucleotide analogs with ...
Pedro Merino, Veronica Juste, Alejandro Montesa, Sandra Pereira, Sara Orta, Manuel Pedrón, Ana I. Jiménez, Sonsoles Martín‐Santamaría, Ramón Hurtado‐Guerrero, Ignacio Delso, Tomás Tejero   +10 more
wiley   +1 more source

Structural snapshots of the reaction coordinate for O-GlcNAc transferase [PDF]

, 2014
Visualization of the reaction coordinate undertaken by glycosyltransferases has remained elusive, but is critical for understanding this important class of enzyme.
Gloster, Tracey M., Jiang, Jiaoyang, Lazarus, Michael B., Vocadlo, David J., Walker, Suzanne, Whitworth, Garrett E., Zandberg, Wesley F.   +6 more
core   +1 more source

Post‐Translational Regulation of CD8+ T Cell Fate and Dysfunction in Tumor Immunity

Advanced Science, Volume 13, Issue 21, 13 April 2026.
This review delineates how post‐translational modifications (PTMs) function as a central regulatory interface governing CD8+ T cell activation, differentiation, persistence, and exhaustion in antitumor immunity. By integrating antigenic, metabolic, and microenvironmental cues, diverse PTM programs coordinate transcriptional and chromatin states that ...
Zihao Zhou, Xu Chen, Nina Li, Meiyan Zou, Yunfan Lin, Pei Lin, Weiyao Feng, Xinyuan Zhao, Li Cui   +8 more
wiley   +1 more source

The decisive role of fumarase: Responsive signaling to glucose deficiency

Molecular & Cellular Oncology, 2018
Our recent study shows that AMPK normally phosphorates fumarase (FH) at Ser75 under glucose deprivation, resulting in FH-ATF2 complex formation that facilitates transcription for cell growth arrest.
Qiujing Yu, Ting Wang, Yuhui Jiang
doaj   +1 more source

The Metabolic Role of Mitochondria in the Perinatal Cardiac Development and Cardiovascular Diseases

Exploration, Volume 6, Issue 2, April 2026.
This review explores the critical role of mitochondria in heart development and cardiovascular disease. It highlights how mitochondrial maturation during embryonic‐to‐postnatal transition, regulated by oxygen and metabolic changes, shapes cardiac structure and function.
Minghao Li, Ruiyi Zhang, Xinyuan Li, Hefeng Huang   +3 more
wiley   +1 more source

Changes in Protein O-GlcNAcylation During Mouse Epididymal Sperm Maturation

Frontiers in Cell and Developmental Biology, 2018
After leaving the testis, sperm undergo two sequential maturational processes before acquiring fertilizing capacity: sperm maturation in the male epididymis, and sperm capacitation in the female reproductive tract.
Darya A. Tourzani, Bidur Paudel, Patricia V. Miranda, Pablo E. Visconti, María G. Gervasi   +4 more
doaj   +1 more source

Post‐translational Modifications in Proteins: Prediction Methods, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Posttranslational modifications (PTMs) serve as rapid and reversible molecular switches that reshape protein activity, stability, and interactomes, thereby governing virtually all physiological cues ranging from signal transduction to epigenetic memory. Mass spectrometry‐based proteomics has substantially expanded our understanding of PTM emergence and
Shuning Zhang, Jingmin Li, Meihuan Chen, Hailong Huang   +3 more
wiley   +1 more source