Results 91 to 100 of about 20,888 (214)
Targeting O-GlcNAcylation to overcome resistance to anti-cancer therapies
Frontiers in Oncology, 2022 In cancer cells, metabolic reprogramming is associated with an alteration of the O-GlcNAcylation homeostasis. This post-translational modification (PTM) that attaches O-GlcNAc moiety to intracellular proteins is dynamically and finely regulated by the O ...
Ninon Very, Ikram El Yazidi-Belkoura
doaj +1 more source
Zhongguo aizheng zazhi, 2020 Background and purpose: O-GlcNAc transferase (OGT) is widely involved in biological behaviors of tumor cells and associated with tumor progression. In this study, we measured expression level of OGT in osteosarcoma tissues, and evaluated its effect on ...
祝开忠 +4 more
doaj
OGA heterozygosity suppresses intestinal tumorigenesis in Apc min/+ mice [PDF]
, 2014 Emerging evidence suggests that aberrant O-GlcNAcylation is associated with tumorigenesis. Many oncogenic factors are O-GlcNAcylated, which modulates their functions.
A Sveen +24 more
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The Journal of Physiology, EarlyView.Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu +7 more
wiley +1 more source
O-GlcNAc-specific antibody CTD110.6 cross-reacts with N-GlcNAc2-modified proteins induced under glucose deprivation. [PDF]
PLoS ONE, 2011 Modification of serine and threonine residues in proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) glycosylation is a feature of many cellular responses to the nutritional state and to stress. O-GlcNAc modification is reversibly regulated by O-linked
Takahiro Isono
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Antioxidants, 2023 Purkinje cells (PCs), as a unique type of neurons output from the cerebellar cortex, are essential for the development and physiological function of the cerebellum.
Fengjiao Liu +10 more
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Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture
Advanced Genetics, Volume 7, Issue 2, June 2026.This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
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Advanced Materials Technologies, Volume 11, Issue 9, 6 May 2026.This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang +4 more
wiley +1 more source
Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.ABSTRACT Cancer cells rewire their metabolism to sustain a high proliferation rate. Sensing external cues is essential to match the metabolic fluxes of the cells to the external stimuli. As part of the glucose metabolism, the hexosamine biosynthesis pathway (HBP) is considered a nutrient‐sensing pathway. The HBP produces UDP‐GlcNAc, a key precursor for
Pegah Rahimizadeh +4 more
wiley +1 more source
Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation [PDF]
, 2018 Elevated O-GlcNAcylation is associated with disease states such as diabetes and cancer. O-GlcNAc transferase (OGT) is elevated in multiple cancers and inhibition of this enzyme genetically or pharmacologically inhibits oncogenesis.
Bacigalupa, Zachary A. +8 more
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