Results 81 to 90 of about 20,888 (214)

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Proteolysis of HCF-1 by Ser/Thr glycosylation-incompetent O-GlcNAc transferase:UDP-GlcNAc complexes [PDF]

, 2016
In complex with the cosubstrate UDP-N-acetylglucosamine (UDP-GlcNAc),O-linked-GlcNAc transferase (OGT) catalyzes Ser/ThrO-GlcNAcylation of many cellular proteins and proteolysis of the transcriptional coregulator HCF-1.
Bhuiyan, Tanja, Borodkin, Vladimir S., Herr, Winship, Kapuria, Vaibhav, Röhrig, Ute F., van Aalten, Daan M F, Zoete, Vincent   +6 more
core   +3 more sources

The N‐Glycome to Differentiate Mesenchymal Stem Cells Upon Chondrogenic Differentiation, Dedifferentiation, and Senescence

PROTEOMICS, EarlyView.
ABSTRACT Mesenchymal stem cells (MSCs) are adult stem cells able to self‐renewal or differentiation into different cell types, including chondrocytes. N‐Glycans are post‐translational modifications of glycoproteins that contribute to vital cell functions.
Houda Montacir, Karina Biskup, Michael Sittinger, Rudolf Tauber, Véronique Blanchard   +4 more
wiley   +1 more source

Nutrient sensitive protein O -GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis

Life Science Alliance, 2022
Maternal hyperglycemia and elevated O-GlcNAc levels perturb promoter bivalency and lead to transcriptional up-regulation of neurogenic transcription factors during embryonic neurogenesis.
Shama Parween, Thilina T Alawathugoda, Ashok D Prabakaran, S Thameem Dheen, Randall H Morse, Bright Starling Emerald, Suraiya A Ansari   +6 more
doaj   +1 more source

O‐GlcNAcylation of KAT2A Enhances Bladder Cancer Proliferation by Inhibiting the KAT2A‐TRIM22 Interaction

Cancer Science, EarlyView.
Lysine acetyltransferase 2A (KAT2A) is a transcriptional coactivator and a member of the Histone Acetyltransferase (HAT) family. While altered KAT2A activity has been implicated in various cancers, its role in bladder cancer (BLCA) remains poorly understood.
Wenjie Yang, Zhaoheng Jin, Ziyi Li, Weifeng Xu, Yingjie Li, Yueqiang Peng, Jie Dong, Lin Ma, Zhigang Ji   +8 more
wiley   +1 more source

Centrosomes: Til O-GlcNAc Do Us Apart

Frontiers in Endocrinology, 2021
The centrosome apparatus is vital for spindle assembly and chromosome segregation during mitotic divisions. Its replication, disjunction and separation have to be fine-tuned in space and time.
Aiyun Yuan, Xiangyan Tang, Jing Li
doaj   +1 more source

Nucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins [PDF]

, 2016
O-linked N-acetylglucosamine modification (O-GlcNAcylation) is a nutrient-dependent protein post-translational modification (PTM), dynamically and reversibly driven by two enzymes: O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) that catalyse the ...
Akimoto, Andrew T. Ferenbach, Banerjee, Butkinaree, Cao, Comer, Corrado, Daan M.F. van Aalten, Daniel Mariappa, Dassanayaka, Dias, Dong, Exner, Frezza, Gawlowski, Gu, Haltiwanger, Haltiwanger, Hanover, Hanover, Hart, Hart, Hofer, Housley, Hu, Hube, Iyer, Iyer, Johnsen, Kreppel, Lazarus, Lazarus, Liu, Love, Love, Lozano, Ma, Ma, Nolte, Olichon, Pathak, Pekkurnaz, Riccardo Trapannone, Ruan, Shafi, Shin, Sohn, Tan, Torres, van den Ent, Walgren, Wang, Yang, Yi, Zhao, Zhou, Zhu   +56 more
core   +3 more sources

Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity [PDF]

, 2020
Type III secretion systems are used by many Gram-negative bacterial pathogens to inject proteins, known as effectors, into the cytosol of host cells. These virulence factors interfere with a diverse array of host signal transduction pathways and cellular
Araujo Garrido, Juan Luis, Bernal Bayard, Joaquín, Ramos Morales, Francisco   +2 more
core   +1 more source

O-GlcNAc transferase inhibitors: current tools and future challenges

Biochemical Society Transactions, 2016
The O-linked N-acetylglucosamine (O-GlcNAc) post-translational modification (O-GlcNAcylation) is the dynamic and reversible attachment of N-acetylglucosamine to serine and threonine residues of nucleocytoplasmic target proteins. It is abundant in metazoa, involving hundreds of proteins linked to a plethora of biological functions with implications in ...
Trapannone, Riccardo, Rafie, Karim, Van Aalten, Daan M. F.   +2 more
openaire   +3 more sources

The Diagnostic Odyssey of a Biochemically Confirmed Case of ML II: The First Western Patient With LYSET Deficiency

Clinical Genetics, EarlyView.
We identify a female patient with a homozygous nonsense variant (p.Gln38Ter) in the LYSET gene. This is the first western report of a challenging case of an extensive diagnostic odyssey and demonstrates that the LYSET gene must be considered in the differential diagnosis when M6P‐labeled lysosomal enzymes are altered.
Fernanda Sperb‐Ludwig, Taciane Alegra, Leonardo Martinello da Rosa, Nataniel Floriano Ludwig, Renata Voltolini Velho, Ida Vanessa Doederlein Schwartz   +5 more
wiley   +1 more source