Results 101 to 110 of about 20,888 (214)

Liver Stiffness Characterization of OGTLKO Mouse Model of Progressive Liver Fibrosis

Journal of Ultrasound in Medicine, Volume 45, Issue 5, Page 1069-1082, May 2026.
Objectives O‐GlcNAcylation plays a key regulatory role in hepatic physiology, and its disruption leads to fibrosis in liver‐specific OGT knockout mice (OGTLKO), making this model valuable for studying advanced metabolic dysfunction‐associated steatohepatitis (MASH).
Gilles Renault, Lenin Chinchilla, Lourdes Massengo, Pierre Monbernard, Fadila Benhamed, Marion Regnier, Raphael Denis, Catherine Postic, Anthony Novell, Jean‐Luc Gennisson   +9 more
wiley   +1 more source

The role of Alg13 N-acetylglucosaminyl transferase in the expression of pathogenic features of Candida albicans. [PDF]

, 2017
Background: The pathogenic potential of Candida albicans depends on adhesion to the host cells mediated by highly glycosylated adhesins, hyphae formation and growth of biofilm. These factors require effective N-glycosylation of proteins.
Janik, Anna, Kruszewska, Joanna S., Niewiadomska, Monika, Palamarczyk, Grazyna, Perlinska-Lenart, Urszula, Piłsyk, Sebastian   +5 more
core   +1 more source

Hcfc1 and Ogt Mediate Zebrafish CNS Regeneration Through Hippo/Yap Signalling

Cell Proliferation, Volume 59, Issue 5, May 2026.
This work identifies Hcfc1 and Ogt as key regulators of zebrafish CNS regeneration through modulation of Hippo/Yap signalling. Loss of Hcfc1 or Ogt activity inhibition impairs regeneration, which is restored by Yap overexpression, revealing a new regulatory axis that enhances CNS regenerative capacity.
Priyanka P. Srivastava, Sidharth Bhasin, Poonam Sharma, Omkar Mahadeo Desai, Kshitiz Yadav, Ayushma, Rohan Chakraborty, Suhel Parvez, Rajesh Ramachandran, Shilpi Minocha   +9 more
wiley   +1 more source

Small molecule splicing modulators that disrupt O-GlcNAc homeostasis

Nature Communications
O-Linked N-acetylglucosamine (O-GlcNAc) is a nucleocytoplasmic post-translational modification that is tightly regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA).
Steven S. Cheng, Alison C. Mody, Amedeo Vetere, Ashwin Govindan, Yewon Lee, Danielle E. Khost, Rohan Narayan, Timothy B. Sackton, Nicholas K. Conrad, Bridget K. Wagner, Christina M. Woo   +10 more
doaj   +1 more source

Effects of exercise on the hexosamine biosynthetic pathway and glycosylation

Journal of Physical Fitness and Sports Medicine, 2012
Minor amounts of glucose incorporated into the cells is metabolized via the hexosamine biosynthetic pathway, resulting in the production of uridine-5’-diphosphate-N-acetylglucosamine (UDP-GlcNAc), which is utilized as a donor substrate for the N- and O ...
Ken Shirato, Takako Kizaki, Hideki Ohno, Kazuhiko Imaizumi   +3 more
doaj   +1 more source

Solving the mystery of human sleep schedules one mutation at a time. [PDF]

, 2013
Sleep behavior remains one of the most enigmatic areas of life. The unanswered questions range from "why do we sleep?" to "how we can improve sleep in today's society?" Identification of mutations responsible for altered circadian regulation of human ...
Fu, Ying-Hui, Hallows, William C, Ptáček, Louis J   +2 more
core   +1 more source

The Split Personality of Human O‐GlcNAc Transferase

The FASEB Journal, 2015
O‐GlcNAc Transferase (OGT) is an essential glycosyltransferase that catalyzes the attachment of N‐acetylglucosamine (GlcNAc) to serines and threonines of numerous nuclear and cytoplasmic proteins. Global O‐GlcNAcylation is sensitive to changes in the concentration of OGT's substrate, UDP‐GlcNAc, which is affected by cellular glucose levels. Increased O‐
openaire   +1 more source

Elevated Expression of O-GlcNAc–Modified Proteins and O-GlcNAc Transferase in Corneas of Diabetic Goto-Kakizaki Rats

Investigative Opthalmology & Visual Science, 2003
The hexosamine biosynthetic pathway is one of the possible mechanisms involved in diabetic keratopathy. The purpose of this study was to examine the role of O-glycoside-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in the pathogenesis of diabetic keratopathy in the Goto-Kakizaki (GK) rat, which has spontaneous development of diabetes ...
Yoshihiro, Akimoto, Hayato, Kawakami, Koji, Yamamoto, Eiji, Munetomo, Tetsuo, Hida, Hiroshi, Hirano   +5 more
openaire   +2 more sources

O-GlcNAc transferase and O-GlcNAcase: achieving target substrate specificity [PDF]

Amino Acids, 2014
O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) catalyze the dynamic cycling of intracellular, post-translational O-GlcNAc modification on thousands of Ser/Thr residues of cytosolic, nuclear, and mitochondrial signaling proteins. The identification of O-GlcNAc modified substrates has revealed a functionally diverse set of proteins, and the extent of O-
Alexis K, Nagel, Lauren E, Ball
openaire   +2 more sources

An atlas of plant selenium metabolism

New Phytologist, Volume 250, Issue 4, Page 2041-2060, May 2026.
Summary Selenium (Se) is not only a rare and toxic element but also an essential micronutrient for humans and animals that is often in short supply. Terrestrial plants do not require Se, but it can have growth‐promoting or negative effects, depending on the exposure level.
Jeroen van der Woude, Mark G. M. Aarts, Michela Schiavon, Antony van der Ent   +3 more
wiley   +1 more source