Results 21 to 30 of about 4,448 (184)
SUMOylation targets O-GlcNAcase to chaperone-mediated autophagy. [PDF]
J Biol ChemO-GlcNAcase (OGA) is the sole eraser for the intracellular O-GlcNAc. OGA has many roles in distinct biological processes, such as cancer and embryonic stem cells, but its precise regulatory mechanism is far from being understood. Herein, we studied the small ubiquitin-like modifier (SUMO) modification of OGA and found that OGA is SUMOylated at K358 ...
Yan S +7 more
europepmc +2 more sources
Frontiers in Immunology, 2022 Inflammation is the immune response to harmful stimuli, including pathogens, damaged cells and toxic compounds. However, uncontrolled inflammation can be detrimental and contribute to numerous chronic inflammatory diseases, such as insulin resistance. At
Lara K. Abramowitz, John A. Hanover
doaj +1 more source
Drosophila O-GlcNAcase Deletion Globally Perturbs Chromatin O-GlcNAcylation. [PDF]
J Biol Chem, 2016 Gene expression during Drosophila development is subject to regulation by the Polycomb (Pc), Trithorax (Trx), and Compass chromatin modifier complexes. O-GlcNAc transferase (OGT/SXC) is essential for Pc repression suggesting that the O-GlcNAcylation of proteins plays a key role in regulating development. OGT transfers O-GlcNAc onto serine and threonine
Akan I +4 more
europepmc +4 more sources
Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis. [PDF]
J Biol Chem, 2021 O-GlcNAcylation is an essential post-translational modification that has been implicated in neurodevelopmental and neurodegenerative disorders. O-GlcNAcase (OGA), the sole enzyme catalyzing the removal of O-GlcNAc from proteins, has emerged as a potential drug target.
Muha V +8 more
europepmc +5 more sources
O-GlcNAcase regulates pluripotency states of human embryonic stem cells. [PDF]
Stem Cell ReportsUnderstanding the regulation of human embryonic stem cells (hESCs) pluripotency is critical to advance the field of developmental biology and regenerative medicine. Despite the recent progress, molecular events regulating hESC pluripotency, especially the transition between naive and primed states, still remain unclear.
Liu Q +8 more
europepmc +3 more sources
Communications Biology, 2022 An in vitro assay in isolated heart mitochondria reveals that O-GlcNAcase inhibitor NButGT rapidly increases protein O-GlcNAcylation leading to increased respiratory capacity and complex I activity and decreased ROS release.
Justine Dontaine +13 more
doaj +1 more source
Frontiers in Neuroscience, 2023 A substantial body of evidence has indicated that intracerebral O-linked N-acetyl-β-D-glucosamine (O-GlcNAc), a generalized post-translational modification, was emerging as an effective regulator of stress-induced emotional and cognitive impairments. Our
Yan Huang +13 more
doaj +1 more source
Frontiers in Oncology, 2022 Blocking ataxia telangiectasia mutated (ATM), a crucial player in DNA repair responses, has been proposed as a promising strategy in anti-cancer therapy.
Ning Wang +5 more
doaj +1 more source
Reduced O-GlcNAcase expression promotes mitotic errors and spindle defects. [PDF]
Cell Cycle, 2016 Alterations in O-GlcNAc cycling, the addition and removal of O-GlcNAc, lead to mitotic defects and increased aneuploidy. Herein, we generated stable O-GlcNAcase (OGA, the enzyme that removes O-GlcNAc) knockdown HeLa cell lines and characterized the effect of the reduction in OGA activity on cell cycle progression.
Lanza C +6 more
europepmc +4 more sources
Increasing O-GlcNAcylation level on organ culture of soleus modulates the calcium activation parameters of muscle fibers. [PDF]
PLoS ONE, 2012 O-N-acetylglucosaminylation is a reversible post-translational modification which presents a dynamic and highly regulated interplay with phosphorylation.
Caroline Cieniewski-Bernard +3 more
doaj +1 more source