Pancreatic β-cell hyper-O-GlcNAcylation leads to impaired glucose homeostasis in vivo
Frontiers in Endocrinology, 2022 Protein O-GlcNAcylation is a nutrient and stress-sensitive protein post-translational modification (PTM). The addition of an O-GlcNAc molecule to proteins is catalyzed by O-GlcNAc transferase (OGT), whereas O-GlcNAcase (OGA) enzyme is responsible for ...
Seokwon Jo +7 more
doaj +1 more source
A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of β-N-acetylglucosaminidases [PDF]
, 2007 The synthesis of an analogue of 6-epi-valienamine bearing an acetamido group and its characterisation as an inhibitor of β-N-acetylglucosaminidases are described.
Adrian Scaffidi +49 more
core +1 more source
Relationship Between O-GlcNAcase Expression and Prognosis of Patients With Osteosarcoma [PDF]
Applied Immunohistochemistry & Molecular Morphology, 2020 Several studies have demonstrated a role of O -GlcNAcylation ( O -GlcNAc) in tumorigenesis of various carcinomas by modification of tumor-associated proteins. However, its implication in the pathogenesis of osteosarcoma remains unclear. This study aimed
Thamonwan Sombutthaweesri +8 more
openaire +3 more sources
A Quantum Mechanics / Molecular Mechanics Study of the Protein-Ligand Interaction of two potent inhibitors of human O-GlcNAcase: PUGNAc and NAG-thiazoline [PDF]
, 2008 O-glycoprotein 2-acetamino-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase) hydrolyzes 2-acetamido-2-deoxy-β-D-glucopyranose (O-GlcNAc) residues of serine/threonine residues of modified proteins.
Kanaan Izquierdo, Natalia +5 more
core +3 more sources
Developmental regulation of protein O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in mammalian brain. [PDF]
PLoS ONE, 2012 O-GlcNAcylation is a common posttranslational modification of nucleocytoplasmic proteins by β-N-acetylglucosamine (GlcNAc). The dynamic addition and removal of O-GlcNAc groups to and from proteins are catalyzed by O-linked N-acetylglucosamine transferase
Ying Liu +11 more
doaj +1 more source
Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain. [PDF]
, 2019 Mounting evidence in animal models indicates potential for rejuvenation of cellular and cognitive functions in the aging brain. However, the ability to utilize this potential is predicated on identifying molecular targets that reverse the effects of ...
Albarran, Eddy +8 more
core +1 more source
O-GlcNAc transferase and O-GlcNAcase: achieving target substrate specificity [PDF]
Amino Acids, 2014 O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) catalyze the dynamic cycling of intracellular, post-translational O-GlcNAc modification on thousands of Ser/Thr residues of cytosolic, nuclear, and mitochondrial signaling proteins. The identification of O-GlcNAc modified substrates has revealed a functionally diverse set of proteins, and the extent of O-
Alexis K, Nagel, Lauren E, Ball
openaire +2 more sources
The effects of O-GlcNAc alteration on Alzheimer-like neurodegeneration in SK-N-SH cells
Biomedical Papers, 2018 Background: O-GlcNAcylation is a highly dynamic post-translational modification that plays a key role in regulating phosphorylation of protein and cell survival.
Nan Ding +6 more
doaj +1 more source
Structural studies of a surface-entropy reduction mutant of O-GlcNAcase. [PDF]
Acta Crystallogr D Struct Biol, 2019 The enzyme O-GlcNAcase catalyses the removal of the O-GlcNAc co/post-translational modification in multicellular eukaryotes. The enzyme has become of acute interest given the intimate role of O-GlcNAcylation in tau modification and stability; small-molecular inhibitors of human O-GlcNAcase are under clinical assessment for the treatment of tauopathies.
Males A, Davies GJ.
europepmc +6 more sources
Substrate specificity provides insights into the sugar donor recognition mechanism of O-GlcNAc transferase (OGT). [PDF]
, 2013 O-Linked β-N-acetylglucosaminyl transferase (OGT) plays an important role in the glycosylation of proteins, which is involved in various cellular events.
Chen, Xi +11 more
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