Results 191 to 200 of about 5,258 (215)

MDR1 and OAT1/OAT3 Mediate the Drug-Drug Interaction between Puerarin and Methotrexate

Pharmaceutical Research, 2013
To conduct in vivo and in vitro experiments to investigate puerarin (PUR), an isoflavone C-glyoside, and elucidate its ability to alter methotrexate (MTX) transport and pharmacokinetics.In vivo absorption studies, in vitro everted intestinal sac preparation, kidney slices in rats and bi-directional transport assay with mock-/MDCK-MDR1 cells, uptake ...
Qi, Liu, Changyuan, Wang, Qiang, Meng, Xiaokui, Huo, Huijun, Sun, Jinyong, Peng, Xiaochi, Ma, Pengyuan, Sun, Kexin, Liu   +8 more
openaire   +2 more sources

OAT1 and OAT3 also mediate the drug-drug interaction between piperacillin and tazobactam

International Journal of Pharmaceutics, 2018
This study aimed to demonstrate that organic anion transporters (OATs) mediate the drug-drug interaction (DDI) between piperacillin and tazobactam. After co-administration with piperacillin in rats, the AUC of tazobactam in plasma was significantly increased, and t1/2β was prolonged with significant reduction in plasma clearance, renal clearance and ...
Shijie, Wen, Changyuan, Wang, Yingjie, Duan, Xiaokui, Huo, Qiang, Meng, Zhihao, Liu, Shilei, Yang, Yanna, Zhu, Huijun, Sun, Xiaodong, Ma, Siyun, Yang, Kexin, Liu   +11 more
openaire   +2 more sources

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics

Clinical Pharmacology & Therapeutics, 2003
Our objective was to quantitate the contribution of the genetic polymorphisms of the genes for 2 human organic anion transporters-organic anion transporting polypeptide C (OATP-C) and organic anion transporter 3 (OAT3)-to the pharmacokinetics of pravastatin.Genetic polymorphisms were screened by polymerase chain reaction-single-strand conformation ...
Yohei, Nishizato, Ichiro, Ieiri, Hiroshi, Suzuki, Miyuki, Kimura, Kiyoshi, Kawabata, Takeshi, Hirota, Hiroshi, Takane, Shin, Irie, Hiroyuki, Kusuhara, Yoko, Urasaki, Akinori, Urae, Shun, Higuchi, Kenji, Otsubo, Yuichi, Sugiyama   +13 more
openaire   +2 more sources

Molecular Cloning and Functional Analyses of OAT1 and OAT3 from Cynomolgus Monkey Kidney

Pharmaceutical Research, 2005
The functional characterization of monkey OAT1 (SLC22A6) and OAT3 (SLC22A8) was carried out to elucidate species differences in the OAT1- and OAT3-mediated transport between monkey and human.The cDNAs of monkey OAT1 and OAT3 were isolated from monkey kidney, and their stable transfectants were established in HEK293 cells (mkOAT1- and mkOAT3-HEK ...
Harunobu, Tahara, Masayuki, Shono, Hiroyuki, Kusuhara, Hajime, Kinoshita, Eiichi, Fuse, Akira, Takadate, Masaki, Otagiri, Yuichi, Sugiyama   +7 more
exaly   +3 more sources

Acute regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules

American Journal of Physiology-Renal Physiology, 2004
We investigated the regulation of organic anion transport driven by the organic anion transporter 3 (OAT3), a multispecific OAT localized at the basolateral membrane of the renal proximal tubule. PMA, a PKC activator, inhibited uptake of estrone sulfate (ES), a prototypic substrate for OAT3, in a dose- and time-dependent manner.
S, Soodvilai, V, Chatsudthipong, K K, Evans, S H, Wright, W H, Dantzler   +4 more
openaire   +2 more sources

Characterization of zebrafish (Danio rerio) organic anion transporters Oat1 and Oat3

2018
OATS/Oats are transmembrane proteins that transport a variety of compounds including drugs, environmental toxins and endogenous metabolites into the cell. Human OAT1 and OAT3 are primarily expressed in the kidney where their physiological role is uptake of urate into the kidneys, thus representing the first step in urate excretion.
Dragojević, Jelena, Popović, Marta, Smital, Tvrtko   +2 more
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Prijenosnik organskih aniona Oat3 u jetri spolno nezrelih štakora

2009
Jetra sudjeluje u sekreciji i/ili reapsorpciji endogenih i egzogenih organskih aniona, uključujući produkte metabolizma, lijekove i toksine, posredstvom različitih transmembranskih prijenosnih proteina. Jedan od njih je prijenosnik organskih aniona 3 u štakora (rOat3) koji pripada porodici Slc22 proteina (Slc22a8).
openaire   +1 more source

Organic anion transporter Oat3 in the liver of prepubertal rats

2009
Jetra sudjeluje u sekreciji i/ili reapsorpciji endogenih i egzogenih organskih aniona, uključujući produkte metabolizma, lijekove i toksine, posredstvom različitih transmembranskih prijenosnih proteina. Jedan od njih je prijenosnik organskih aniona 3 u štakora (rOat3) koji pripada porodici Slc22 proteina (Slc22a8).
openaire  

OAT3

2022
openaire   +1 more source

OAT3, Organic Anion Transporter 3

2007
Yohannes Hagos, Gerhard Burckhardt
openaire   +1 more source