Results 181 to 190 of about 5,258 (215)

Dihydrophenanthrenes from Juncus effusus as Inhibitors of OAT1 and OAT3

Journal of Natural Products, 2019
Organic anion transporters 1 (OAT1) and 3 (OAT3) play important roles in the renal elimination of a range of substrate molecules. Little is known about natural products that can modulate OAT1 and OAT3 activities. The medullae of Juncus effusus is often used for the treatment of dysuria in traditional Chinese medicine.
Xue Li, Yilin Qiao, Xue Wang, Ruicong Ma, Tianxiang Li, Youcai Zhang, Robert P. Borris   +6 more
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Chlorothiazide is a Substrate for the Human Uptake Transporters OAT1 and OAT3

Journal of Pharmaceutical Sciences, 2013
The thiazide diuretic chlorothiazide is poorly metabolized, and is predominantly excreted via the kidneys. We have previously shown that chlorothiazide is transported by ATP-binding cassette transporter G2, suggesting a potential role for this transporter in apical efflux of chlorothiazide in the kidney.
Viktória, Juhász, Erzsébet, Beéry, Zoltán, Nagy, Annamária, Bui, Eva, Molnár, Joseph Krisjanis, Zolnerciks, Rémi, Magnan, Márton, Jani, Peter, Krajcsi   +8 more
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Benzylpenicillin inhibits the renal excretion of acyclovir by OAT1 and OAT3

Pharmacological Reports, 2013
Acyclovir is acyclic guanosine derivative. Benzylpenicillin (PCG) is a β-lactam antibiotic. The purpose of this study was to investigate the pharmacokinetic drug-drug interaction (DDI) between PCG and acyclovir.When acyclovir and PCG were co-administered, plasma concentration of acyclovir, urinary excretion of acyclovir in vivo, uptake of acyclovir in ...
Jianghao, Ye, Qi, Liu, Changyuan, Wang, Qiang, Meng, Huijun, Sun, Jinyong, Peng, Xiaochi, Ma, Kexin, Liu   +7 more
openaire   +2 more sources

Isoflavones from Camphorosma lessingii Inhibit the Organic Anion Transporters OAT1 and OAT3

Planta Medica, 2018
AbstractPhytochemical investigation of Camphorosma lessingii has resulted in the isolation of four previously unreported isoflavones (1–4) and eight known compounds (5–12). Nine of these compounds (1–6, 8–10) are reported for the first time from members of the family Amaranthaceae.
Xinhui, Wang, Dujuan, Wang, Xue, Wang, Manana, Khutsishvili, Kamilla, Tamanyan, George, Fayvush, Daniel, Atha, Youcai, Zhang, Robert P, Borris   +8 more
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Caffeic acid inhibits organic anion transporters OAT1 and OAT3 in rat kidney

dmdi, 2013
Abstract Background: Some food components influence drug elimination. Previously, we found that caffeic acid, present in coffee, fruits, and vegetables, strongly inhibited human homologs of organic anion transporters (OATs) OAT1 and OAT3, which are responsible for renal tubular secretion of anionic drugs. In this study,
Yuichi, Uwai, Tatsuya, Kawasaki, Tomohiro, Nabekura   +2 more
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Renal Expression and Function of Oat1 and Oat3 in Rats with Vascular Calcification

Pharmacology, 2012
Calcium overload in vascular smooth muscle is a highly pathogenic event, which progresses with advancing age. Old patients are polymedicated, and several pharmacotherapeutic agents circulate in the plasma as organic anions. The organic anion transporters 1 and 3 (Oat1 and Oat3) are present in renal basolateral membranes, which transport organic anions ...
Romina, Bulacio, María Herminia, Hazelhoff, Adriana Mónica, Torres   +2 more
openaire   +2 more sources

New insight in cell localization of Oat3 in the mouse kidney : different sex-dependent expression of Oat3 and Oat1

2012
Immunolocalization of the organic anion transporter 3 in the mouse kidney (mOAT3, Slc22a8) was previously studied with antibodies against the rat (rOAT3-Ab) and mouse (mOAT3-Ab) proteins, and detected in both species in the basolateral membrane (BLM) of various nephron segments, including proximal tubule (PT), thick ascending limb of Henle, cortical ...
Breljak, Davorka, Brzica, Hrvoje, Sweet, Douglas H., Anzai, Naohiko, Sabolić, Ivan   +4 more
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Expression and function of Oat1 and Oat3 in rat kidney exposed to mercuric chloride

Archives of Toxicology, 2009
This study was designed to evaluate the expression and function of the organic anion transporters, Oat1 and Oat3, in rats exposed to a nephrotoxic dose of HgCl(2). Oat1 protein expression increased in renal homogenates and decreased in renal basolateral membranes from HgCl(2) rats, while Oat3 protein abundance decreased in both kidney homogenates and ...
Gisela Di Giusto, Naohiko Anzai, Adriana Mónica Torres   +2 more
exaly   +3 more sources

Abstract 5471: Identification of OAT1/OAT3 as contributors to cisplatin nephrotoxicity

Cancer Research, 2015
Abstract Cisplatin is among the most widely used anticancer drugs and known to cause dose-limiting nephrotoxicity. We previously reported that renal organic cation transporters (OCT2 in humans, Oct1/Oct2 in mice) are involved in the etiology of this side effect (Filipski et al, CPT 2009), but the tubular damage is not completely ...
Shuiying Hu, Navjotsingh Pabla, Laura J. Janke, Lie Li, Aksana Vasilyeva, Jason A. Sprowl, Alex Sparreboom   +6 more
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Transport of Xanthurenic Acid by Rat/Human Organic Anion Transporters OAT1 and OAT3

Bioscience, Biotechnology, and Biochemistry, 2013
Kynurenic acid, a tryptophan metabolite, is involved in psychiatric disease. Our laboratory previously described its transport by rat/human organic anion transporters rOAT1, hOAT1, rOAT3 and hOAT3, which are involved in drug disposition. In this study, we performed an uptake experiment using Xenopus laevis oocytes to examine the transport of ...
Yuichi, Uwai, Emi, Honjo
openaire   +2 more sources