Drug-induced hyperuricemia: multi-pathway regulation, causative drugs, and individualized management strategies. [PDF]
Front PharmacolXiong B +6 more
europepmc +1 more source
A novel Chinese medicine formula against hyperuricemia-induced kidney inflammation involving pyroptosis inhibition via modulating AMPK-TLR4-NLRP3 pathway. [PDF]
Chin MedTian YY +5 more
europepmc +1 more source
Sex-Dependent Expression of Oat3 (Slc22a8) and Oat1 (Slc22a6) Proteins in Murine Kidneys [PDF]
American Journal of Physiology - Renal Physiology, 2013 In the mouse kidney, organic anion transporter 3 (mOat3, Slc22a8) was previously localized to the basolateral membrane (BLM) of proximal tubule (PT), thick ascending limb of Henle, macula densa, distal tubule, and cortical collecting duct.
Davorka Breljak +2 more
exaly +6 more sources
Reduced Renal Clearance of Cefotaxime in Asians With a Low-Frequency Polymorphism of OAT3 (SLC22A8) [PDF]
Journal of Pharmaceutical Sciences, 2013 Organic anion transporter 3 (OAT3, SLC22A8), a transporter expressed on the basolateral membrane of the proximal tubule, plays a critical role in the renal excretion of organic anions including many therapeutic drugs.
Kathleen Giacomini +2 more
exaly +7 more sources
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Expression and Function of Oat1 and Oat3 in Rat Kidney Exposed to Mercuric Chloride
Archives of Toxicology, 2009This study was designed to evaluate the expression and function of the organic anion transporters, Oat1 and Oat3, in rats exposed to a nephrotoxic dose of HgCl(2). Oat1 protein expression increased in renal homogenates and decreased in renal basolateral membranes from HgCl(2) rats, while Oat3 protein abundance decreased in both kidney homogenates and ...
Gisela Di Giusto +2 more
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Organic anion transporters (OATs) are membrane proteins within the Solute carrier family 22 (SLC22). They play important roles in cellular uptake of various organic compounds, and due to their expression in barrier tissues of major excretory and non-excretory organs are considered as crucial elements in absorption and distribution of a wide range of ...
Ivan Mihaljevic +2 more
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Chlorothiazide is a Substrate for the Human Uptake Transporters OAT1 and OAT3
Journal of Pharmaceutical Sciences, 2013The thiazide diuretic chlorothiazide is poorly metabolized, and is predominantly excreted via the kidneys. We have previously shown that chlorothiazide is transported by ATP-binding cassette transporter G2, suggesting a potential role for this transporter in apical efflux of chlorothiazide in the kidney.
Viktória, Juhász +8 more
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Benzylpenicillin inhibits the renal excretion of acyclovir by OAT1 and OAT3
Pharmacological Reports, 2013Acyclovir is acyclic guanosine derivative. Benzylpenicillin (PCG) is a β-lactam antibiotic. The purpose of this study was to investigate the pharmacokinetic drug-drug interaction (DDI) between PCG and acyclovir.When acyclovir and PCG were co-administered, plasma concentration of acyclovir, urinary excretion of acyclovir in vivo, uptake of acyclovir in ...
Jianghao, Ye +7 more
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The Drug Transporter OAT3 (SLC22A8) and Endogenous Metabolite Communication via the Gut–Liver–Kidney Axis [PDF]
Journal of Biological Chemistry, 2017 The organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC22A8) have similar substrate specificity for drugs, but it is far from clear whether this holds for endogenous substrates.
Kevin T Bush, Sanjay Nigam
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Renal Expression and Function of Oat1 and Oat3 in Rats with Vascular Calcification
Pharmacology, 2012Calcium overload in vascular smooth muscle is a highly pathogenic event, which progresses with advancing age. Old patients are polymedicated, and several pharmacotherapeutic agents circulate in the plasma as organic anions. The organic anion transporters 1 and 3 (Oat1 and Oat3) are present in renal basolateral membranes, which transport organic anions ...
Romina, Bulacio +2 more
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