Results 171 to 180 of about 5,258 (215)

Human and rat renal proximal tubule in vitro models for ADME applications. [PDF]

Arch Toxicol
Klatt OC, de Brouwer L, Hendriks F, Dehne EM, Ataç Wagegg B, Jennings P, Wilmes A.   +6 more
europepmc   +1 more source

Pharmacotherapy in kidney disease: what it takes to move from general guidance to specific recommendations to stratified subgroups of patients - the tale of autosomal dominant polycystic kidney disease (ADPKD). [PDF]

Expert Opin Drug Metab Toxicol
Tillmann AC, Rostami-Hodjegan A, Barber J, Al-Majdoub ZM.   +3 more
europepmc   +1 more source

In Vivo Regulation of Small Molecule Natural Products, Antioxidants, and Nutrients by OAT1 and OAT3. [PDF]

Nutrients
Falah K, Zhang P, Nigam AK, Maity K, Chang G, Granados JC, Momper JD, Nigam SK.   +7 more
europepmc   +1 more source

Probenecid Inhibits Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase Mitogen-Activated Protein Kinase Pathways in Regulating Respiratory Syncytial Virus Response. [PDF]

Int J Mol Sci
Jones LP, Bergeron HC, Martin DE, Murray J, Sancilio FD, Tripp RA.   +5 more
europepmc   +1 more source

Sex-dependent expression of Oat3 (Slc22a8) and Oat1 (Slc22a6) proteins in murine kidneys [PDF]

American Journal of Physiology - Renal Physiology, 2013
In the mouse kidney, organic anion transporter 3 (mOat3, Slc22a8) was previously localized to the basolateral membrane (BLM) of proximal tubule (PT), thick ascending limb of Henle, macula densa, distal tubule, and cortical collecting duct. However, the specificity of anti-Oat3 antibodies (Oat3-Ab) used in these studies was not properly verified ...
Davorka Breljak, Douglas H Sweet, Naohiko Anzai   +2 more
exaly   +5 more sources

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Environmental contaminants modulate transport activity of zebrafish organic anion transporters Oat1 and Oat3

Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 2020
Organic anion transporters (OATs) are transmembrane proteins which belong to SLC22 subfamily. They are responsible for the uptake of various endo- and xenobiotics into the cells of different organs and tissues. Following our previous work on characterization of zebrafish Oat1 and Oat3, in this study we analyzed interaction of various classes of ...
Marta Popovic, Ivan Mihaljevic, Tvrtko Smital   +2 more
exaly   +5 more sources

Zebrafish (Danio rerio) Oat1 and Oat3 transporters and their interaction with physiological compounds

Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 2019
Organic anion transporters (OATs) are membrane proteins within the Solute carrier family 22 (SLC22). They play important roles in cellular uptake of various organic compounds, and due to their expression in barrier tissues of major excretory and non-excretory organs are considered as crucial elements in absorption and distribution of a wide range of ...
Ivan Mihaljevic, Marta Popovic, Tvrtko Smital   +2 more
exaly   +6 more sources

Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis

American Journal of Physiology-Renal Physiology, 2008
During cholestasis, bile acids are mainly excreted into the urine, but adaptive renal responses to cholestasis, especially molecular mechanisms for renal secretion of bile acids, have not been well understood. Organic anion transporters (OAT1 and OAT3) are responsible for membrane transport of anionic compounds at the renal basolateral membranes.
Jiarong, Chen, Tomohiro, Terada, Ken, Ogasawara, Toshiya, Katsura, Ken-ichi, Inui   +4 more
openaire   +2 more sources