Results 171 to 180 of about 3,886 (197)

The Contribution of Organic Anion Transporters OAT1 and OAT3 to the Renal Uptake of Rosuvastatin

The Journal of Pharmacology and Experimental Therapeutics, 2007
No description ...
Windass A, Lowes S, Wang Y, Brown C
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Molecular Cloning and Functional Analyses of OAT1 and OAT3 From Cynomolgus Monkey Kidney

Pharmaceutical Research, 2005
The functional characterization of monkey OAT1 (SLC22A6) and OAT3 (SLC22A8) was carried out to elucidate species differences in the OAT1- and OAT3-mediated transport between monkey and human.The cDNAs of monkey OAT1 and OAT3 were isolated from monkey kidney, and their stable transfectants were established in HEK293 cells (mkOAT1- and mkOAT3-HEK ...
Hiroyuki Kusuhara, Akira Takadate
exaly   +3 more sources

Abstract 5471: Identification of OAT1/OAT3 as contributors to cisplatin nephrotoxicity

Cancer Research, 2015
Abstract Cisplatin is among the most widely used anticancer drugs and known to cause dose-limiting nephrotoxicity. We previously reported that renal organic cation transporters (OCT2 in humans, Oct1/Oct2 in mice) are involved in the etiology of this side effect (Filipski et al, CPT 2009), but the tubular damage is not completely ...
Shuiying Hu, Navjotsingh Pabla, Laura J. Janke, Lie Li, Aksana Vasilyeva, Jason A. Sprowl, Alex Sparreboom   +6 more
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New insight in cell localization of Oat3 in the mouse kidney : different sex-dependent expression of Oat3 and Oat1

2012
Immunolocalization of the organic anion transporter 3 in the mouse kidney (mOAT3, Slc22a8) was previously studied with antibodies against the rat (rOAT3-Ab) and mouse (mOAT3-Ab) proteins, and detected in both species in the basolateral membrane (BLM) of various nephron segments, including proximal tubule (PT), thick ascending limb of Henle, cortical ...
Brzica, Hrvoje, Breljak, Davorka, Sabolić, Ivan   +2 more
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Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis

American Journal of Physiology-Renal Physiology, 2008
During cholestasis, bile acids are mainly excreted into the urine, but adaptive renal responses to cholestasis, especially molecular mechanisms for renal secretion of bile acids, have not been well understood. Organic anion transporters (OAT1 and OAT3) are responsible for membrane transport of anionic compounds at the renal basolateral membranes.
Jiarong, Chen, Tomohiro, Terada, Ken, Ogasawara, Toshiya, Katsura, Ken-ichi, Inui   +4 more
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Caffeic acid inhibits organic anion transporters OAT1 and OAT3 in rat kidney

dmdi, 2013
Abstract Background: Some food components influence drug elimination. Previously, we found that caffeic acid, present in coffee, fruits, and vegetables, strongly inhibited human homologs of organic anion transporters (OATs) OAT1 and OAT3, which are responsible for renal tubular secretion of ...
Yuichi, Uwai, Tatsuya, Kawasaki, Tomohiro, Nabekura   +2 more
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MDR1 and OAT1/OAT3 Mediate the Drug-Drug Interaction between Puerarin and Methotrexate

Pharmaceutical Research, 2013
To conduct in vivo and in vitro experiments to investigate puerarin (PUR), an isoflavone C-glyoside, and elucidate its ability to alter methotrexate (MTX) transport and pharmacokinetics.In vivo absorption studies, in vitro everted intestinal sac preparation, kidney slices in rats and bi-directional transport assay with mock-/MDCK-MDR1 cells, uptake ...
Qi, Liu, Changyuan, Wang, Qiang, Meng, Xiaokui, Huo, Huijun, Sun, Jinyong, Peng, Xiaochi, Ma, Pengyuan, Sun, Kexin, Liu   +8 more
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Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics

Clinical Pharmacology & Therapeutics, 2003
Our objective was to quantitate the contribution of the genetic polymorphisms of the genes for 2 human organic anion transporters-organic anion transporting polypeptide C (OATP-C) and organic anion transporter 3 (OAT3)-to the pharmacokinetics of pravastatin.Genetic polymorphisms were screened by polymerase chain reaction-single-strand conformation ...
Yohei, Nishizato, Ichiro, Ieiri, Hiroshi, Suzuki, Miyuki, Kimura, Kiyoshi, Kawabata, Takeshi, Hirota, Hiroshi, Takane, Shin, Irie, Hiroyuki, Kusuhara, Yoko, Urasaki, Akinori, Urae, Shun, Higuchi, Kenji, Otsubo, Yuichi, Sugiyama   +13 more
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Isoflavones from Camphorosma lessingii Inhibit the Organic Anion Transporters OAT1 and OAT3

Planta Medica, 2018
AbstractPhytochemical investigation of Camphorosma lessingii has resulted in the isolation of four previously unreported isoflavones (1–4) and eight known compounds (5–12). Nine of these compounds (1–6, 8–10) are reported for the first time from members of the family Amaranthaceae.
Xinhui, Wang, Dujuan, Wang, Xue, Wang, Manana, Khutsishvili, Kamilla, Tamanyan, George, Fayvush, Daniel, Atha, Youcai, Zhang, Robert P, Borris   +8 more
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OAT1 and OAT3 also mediate the drug-drug interaction between piperacillin and tazobactam

International Journal of Pharmaceutics, 2018
This study aimed to demonstrate that organic anion transporters (OATs) mediate the drug-drug interaction (DDI) between piperacillin and tazobactam. After co-administration with piperacillin in rats, the AUC of tazobactam in plasma was significantly increased, and t1/2β was prolonged with significant reduction in plasma clearance, renal clearance and ...
Shijie, Wen, Changyuan, Wang, Yingjie, Duan, Xiaokui, Huo, Qiang, Meng, Zhihao, Liu, Shilei, Yang, Yanna, Zhu, Huijun, Sun, Xiaodong, Ma, Siyun, Yang, Kexin, Liu   +11 more
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