Letter: long‐term treatment of severe bile acid diarrhoea—obeticholic acid can normalise Se
, 2018 Julian R.F. Walters
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OP02 The first new monotherapy therapeutic PBC study in a decade? An international study evaluating the farnesoid X receptor agonist obeticholic acid in PBC: Abstract OP02 Table 1 [PDF]
, 2011 Diana Jones +10 more
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Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats [PDF]
, 2013 Len Verbeke +10 more
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An efficient regioconvergent synthesis of 3-aza-obeticholic acid
SteroidsBile acids (BAs) are steroidal molecules that play important roles in nutrient absorption, distribution, and excretion. They also act on specific receptors implicated in various metabolic and inflammatory diseases demonstrating their importance as potential drug candidates. Accordingly, there has been a concerted effort to develop new BA derivatives to
Lawrence D. Harris +7 more
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Trials of obeticholic acid for non-alcoholic steatohepatitis [PDF]
The Lancet, 2015 Musso, Giovanni +2 more
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Unravelling the therapeutic landscape of bile acid-based therapies in gastrointestinal disorders
The Saudi Journal of GastroenterologyBile acids serve as endogenous ligands for nuclear and cell membrane receptors and play a crucial role in bile acid and lipid metabolism. These detergent-like compounds promote bile flow and aid in the absorption of dietary fats and fat-soluble vitamins ...
Bandar D. Alrehaili
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Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine, Midazolam, Warfarin, Dextromethorphan, Omeprazole, Rosuvastatin, and Digoxin in Phase 1 Studies in Healthy Subjects [PDF]
, 2017 Jeffrey E. Edwards +4 more
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Stability Indicating RP-HPLC Method Development and Validation for the Quantification of Obeticholic Acid in Bulk and its Pharmaceutical Dosage Form [PDF]
, 2020 R. Kiran Jyothi +3 more
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A variant of FGF19 for treatment of disorders of cholestasis and bile acid metabolism. [PDF]
, 2015 Appleby, RN, Walters, JR
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Reply to: “Obeticholic acid and hepatic bile acids: Excellent study faulty conclusion” [PDF]
Journal of Hepatology, 2021 Susanne Keiding +2 more
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