Acta Medica, 2006 In this work, in vitro potency of novel serie of monoquaternary pyridinium oximes to reactivate cyclosarin-inhibited acetylcholinesterase (AChE) was tested.
Kamil Kuča, Jan Pícha, Daniel Jun
doaj +1 more source
Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats: Survival Study [PDF]
, 2015 There are a great number of reports with assertions that oxidative stress is produced by organophosphorus compound (OPC) poisoning and is a cofactor of mortality and morbidity in OPC toxicity.
Abdu Adem +5 more
core +3 more sources
Treatment efficacy in a soman-poisoned guinea pig model: added value of physostigmine? [PDF]
, 2010 Current treatment of organophosphate poisoning is insufficient, and survivors may suffer from long-lasting adverse effects, such as cognitive deficits and sleep-wake disturbances.
A Gnagey +36 more
core +5 more sources
Effect of Seven Newly Synthesized and Currently Available Oxime Cholinesterase Reactivators on Cyclosarin-Intoxicated Rats [PDF]
, 2009 Seven new oxime-based acetylcholinesterase reactivators were compared with three currently available ones (obidoxime, trimedoxime, HI-6) for their ability to lessen cholinesterase inhibition in blood and brain of cyclosarin-treated rats.
Bajgar +33 more
core +4 more sources
Cyclosarin-An Organophosphate Nerve Agent [PDF]
, 2005 Organophosphorus compounds ascribed to as nerve agents (sarin, soman, tabun, cyclosarin) are highly toxic, and are considered to be the most dangerous chemical compounds.
Krejcova, G., Kuca, K., Sevelova, L.
core +2 more sources
Acta Medica, 2004 Summary: 1. The influence of the time of administration of antidotal treatment consisting of anticholinergic drug (atropine) and oxime (pralidoxime, obidoxime, HI-6 or trimedoxime) on its effectiveness to eliminate tabun-induced lethal effects was ...
Jiří Kassa
doaj +1 more source
Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification. [PDF]
, 2014 Intoxication by organophosphate (OP) nerve agents and pesticides should be addressed by efficient, quickly deployable countermeasures such as antidotes reactivating acetylcholinesterase or scavenging the parent OP.
Amitai, Gabriel +5 more
core
Novel Group of AChE Reactivators—Synthesis, In Vitro Reactivation and Molecular Docking Study
Molecules, 2018 The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam.
David Malinak +4 more
doaj +1 more source
Antidote Stocking at Hospitals in North Palestine [PDF]
, 2007 Objective: The purpose of this study was to determine the availability and adequacy of antidote stocking at hospitals in north Palestine based on published guidelines for antidote stocking.
Al-Jabi W, Samah +3 more
core +1 more source
Reactivation of Human Acetylcholinesterase and Butyrylcholinesterase Inhibited by Leptophos-Oxon with Different Oxime Reactivators in Vitro [PDF]
, 2010 We have evaluated in vitro the potency of 23 oximes to reactivate human erythrocyte acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BChE) inhibited by racemic leptophos-oxon (O-[4-bromo-2,5-dichlorophenyl]-O-methyl phenyl-phosphonate), a ...
Bajgar +20 more
core +3 more sources