Results 61 to 70 of about 1,214 (179)
Protein Science, Volume 33, Issue 5, May 2024.Abstract Chemical warfare nerve agents and pesticides, known as organophosphorus compounds inactivate cholinesterases (ChEs) by phosphorylating the serine hydroxyl group located at the active site of ChEs. Over the course of time, phosphorylation is followed by loss of an organophosphate‐leaving group and the bond with ChEs becomes irreversible, a ...
Jure Stojan +3 more
wiley +1 more source
Acta Medica, 2007 Nerve agents and pesticides belong to the group of organophosphates. They are able to inhibit irreversibly the enzyme acetylcholinesterase (AChE). Acetylcholinesterase reactivators were designed for the treatment of nerve agent intoxications.
Kamil Musílek, Kamil Kuča, Daniel Jun
doaj +1 more source
Recent advances in cholinergic mechanisms as reactions to toxicity, stress, and neuroimmune insults
Journal of Neurochemistry, Volume 168, Issue 4, Page 355-369, April 2024.We reviewed the current advances in our understanding of the effects of a variety of stressors in order to connect acute poisoning with organophosphates, neurotoxicity, changes in microRNAs, and transfer RNA fragments with cholinergic signaling dysfunction.
Zrinka Kovarik +3 more
wiley +1 more source
Anticholinergic Drugs – Functional Antidotes for the Treatment of Tabun Intoxication
Acta Medica, 2004 Summary: 1. To study the influence of antidotes on tabun-induced neurotoxicity, the rats were injected intramuscularly with organophosphate tabun (LD50).
Gabriela Krejčová, Jiří Kassa
doaj +1 more source
Examination of effectiveness of chemical scavengers as therapeutics in organophosphate poisoning [PDF]
, 2017 Cholinergic crisis triggered by inhibition of cholinesterases via organophosphorus nerve agents (OP) and pesticides is treated with atropine and a reactivator of inhibited cholinesterase, called oxime.
Bierwisch, Anne
core
Acta Medica, 2006 In the past, scientists focused on the development of antidotes (mainly anticholinergics in combination with reactivators of inhibited acetylcholinesterase – oximes) to increase the number of surviving nerve agent-intoxicated individuals.
Gabriela Kunešová, Jiří Kassa
doaj +1 more source
Effect of Several New and Currently Available Oxime Cholinesterase Reactivators on Tabun-intoxicated Rats [PDF]
, 2008 The therapeutical efficacies of eleven oxime-based acetylcholinesterase reactivators were compared in an in vivo (rat model) study of treatment of intoxication caused by tabun.
Bajgar +33 more
core +3 more sources
Acta Medica, 2001 1. The influence of anticholinergic drugs (atropine, benactyzine, biperiden) on the efficacy of monopyridinium and bispyridinium oximes (HI-6, BI-6, obidoxime, pralidoxime, methoxime) on soman-induced supralethal poisoning was studied in mice. 2.
Jiří Kassa
doaj +1 more source
Organophosphate Insecticide Poisoning and Parkinsonism
Pediatric Neurology Briefs, 2005 Extrapyramidal parkinsonism in a 14 year-old boy developed 5 days after the accidental ingestion of a raw eggplant sprayed with the organophosphate dimethoate (Rogor), in a report from Meyer Children Hospital, Rappaport School of Medicine, Haifa, Israel.
J Gordon Millichap
doaj +1 more source
The Mechanism by Which Oximes Reactivate Cholinesterases Inhibited by Organophosphates [PDF]
, 2013 The enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are inhibited by nerve agents such as sarin and tabun. In general, the inhibited enzymes are reactivated by bisquaternary ammonium compounds (oximes).
Bhavaraju, Manikanthan Hari Naga Venkata
core +1 more source