Results 141 to 150 of about 67,898 (346)

Fifty-kDa Hyaluronic Acid Upregulates Some Epidermal Genes without Changing TNF-α Expression in Reconstituted Epidermis [PDF]

, 2011
Background: Due to its strong water binding potential, hyaluronic acid (HA) is a well-known active ingredient for cosmetic applications. However, based on its varying molecular size, skin penetration of HA may be limited. Recent studies have demonstrated
B. Malle, Baccarani-Contri M, Bhattacharya J, G. Gauglitz, G. Schmitz, H.C. Korting, K. Schwach-Abdellaoui, M. Farwick, M. Wegmann, Mehul B, Noble PW, T. Köhler, T. Pavicic, Turino GM, V. Tarabin, Weigel PH   +15 more
core   +2 more sources

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

Advanced Science, EarlyView.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu, Jiajia Zhuo, Xiaoquan Hong, Shihao Rao, Yafang Ye, Dandan Kang, Huifang Peng, Huiqin Zhuo   +7 more
wiley   +1 more source

Early loss of blood-brain barrier integrity precedes NOX2 elevation in the prefrontal cortex of an animal model of psychosis [PDF]

, 2016
The social isolation rearing of young adult rats is a model of psychosocial stress and provides a nonpharmacological tool to study alterations reminiscent of symptoms seen in psychosis.
Bove, Maria, Cuomo, Vincenzo, Di Giovanni, Giuseppe, Mhillaj, Emanuela, Morgese, Maria Grazia, Neri, Margherita, Pomara, Cristoforo, Schiavone, Stefania, Trabace, Luigia, Tucci, Paolo, Turillazzi, Emanuela, Valentino, Mario   +11 more
core   +4 more sources

Roles of claudin-2, ZO-1 and occludin in leaky HK-2 cells

PLoS ONE, 2017
Background Claudin-2, ZO-1, and occludin are major components of tight junctions (TJs) in the proximal tubule. However, their roles in maintaining paracellular permeability as leaky epithelia have yet to be defined.
Sua Kim, G. Kim
semanticscholar   +1 more source

The second extracellular loop dictates Occludin-mediated HCV entry

Virology, 2010
Recent findings have implicated tight junction (TJ) protein Occludin (OCLN) as an essential factor for hepatitis C virus (HCV) to enter human hepatocytes. To gain insights into OCLN-mediated HCV entry, we created a panel of OCLN deletion mutants and found that without impairing OCLN's cell surface localization, removal of the extracellular loop 2 (EL2)
Liu, Shufeng, Kuo, Wayne, Yang, Wei, Liu, Weiqun, Gibson, Gregory A., Dorko, Kenneth, Watkins, Simon C., Strom, Stephen C., Wang, Tianyi   +8 more
openaire   +2 more sources

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

The development of metabolic endotoxemia is dependent on the type of sweetener and the presence of saturated fat in the diet

Gut Microbes, 2020
Fat and sweeteners contribute to obesity. However, it is unknown whether specific bacteria are selectively modified by different caloric and noncaloric sweeteners with or without a high-fat diet (HFD).
Mónica Sánchez-Tapia, Aaron W. Miller, Omar Granados-Portillo, Armando R. Tovar, Nimbe Torres   +4 more
doaj   +1 more source

Polarization restricts hepatitis C virus entry into HepG2 hepatoma cells [PDF]

, 2009
The primary reservoir for hepatitis C virus (HCV) replication is believed to be hepatocytes, which are highly polarized with tight junctions (TJ) separating their basolateral and apical domains.
Balfe, Peter, Davis, Christopher, Farquhar, Michelle J, Harris, Helen J, McKeating, Jane A, Mee, Christopher J, Reynolds, Gary, van IJzendoorn, Sven C D, Wilson, Garrick   +8 more
core   +3 more sources

Campylobacter jejuni outer membrane vesicle‐associated proteolytic activity promotes bacterial invasion by mediating cleavage of intestinal epithelial cell E‐cadherin and occludin

Cellular Microbiology, 2016
Outer membrane vesicles (OMVs) play an important role in the pathogenicity of Gram‐negative bacteria. Campylobacter jejuni produces OMVs that trigger IL‐8, IL‐6, hBD‐3 and TNF‐α responses from T84 intestinal epithelial cells and are cytotoxic to Caco‐2 ...
A. Elmi, Fauzy Nasher, H. Jagatia, O. Gundogdu, M. Bajaj‐Elliott, B. Wren, N. Dorrell   +6 more
semanticscholar   +1 more source