Results 131 to 140 of about 39,916 (217)

Microglial Activation Plays a Critical Role in LPS-Induced Contextual Fear Memory Consolidation Impairment and Blood-Brain Barrier Disruption. [PDF]

Brain Behav
Zheng J, Li L, Jin X, Liu W.
europepmc   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Differential Effects of Cannabidiol and Cannabigerol on Cognition, Neuroinflammation, and Blood-Brain Barrier Integrity in a Rat Model of Iron Overload. [PDF]

Neurotox Res
Kowalski L, Colucci ACM, Dos Santos JB, Vuaden BW, Herlinger AL, Hallak JEC, Zuardi AW, Crippa JAS, de Lima MNM, Schröder N.   +9 more
europepmc   +1 more source

Betulinic Acid Enema Alleviates Colitis by Targeting Vitamin D Receptor to Protect the Intestinal Mucosal Barrier and Modulate Mucosa‐Associated Microbiota

Phytotherapy Research, EarlyView.
ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with limited effectiveness and safety of current drug therapies. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid present in traditional Chinese medicines used clinically as retention enemas for UC, but its direct effects and mechanisms remain unclear ...
Lina Dong, Yuanxia Gao, Qian Li, Guangxin Chen, Dong Yang, Liping Zhao, Xiaojing Liu, Shumei Lin   +7 more
wiley   +1 more source

Expression and localization of tight, adherens, and gap junction proteins in the chicken ovary during pause in laying induced by fasting. [PDF]

Poult Sci
Frydrych K, Machura MH, Hrabia A.
europepmc   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

Targeting PPARγ-NF-κB: (+)-catechin reverses <i>Clostridioides difficile</i> toxin A-induced intestinal barrier dysfunction. [PDF]

Future Microbiol
Li S, Luan Y, Li Z, Lu Y, Lai D, Chen K.
europepmc   +1 more source

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Responsive Materials, EarlyView.
This review presents the structure and transport routes of the blood‐brain barrier, summarizes the ischemic stroke pathophysiological cascade, and discusses the BBB‐crossing mechanisms and multitarget therapeutic effects of carbon dots, demonstrating their promising theranostic potential for ischemic stroke.
Yanhan Huang, Xuan Hou, Haiping Zhao, Qi Kong, Xiayan Wang, Xiaokun Geng, Zaicheng Sun   +6 more
wiley   +1 more source

Effective-Component Compatibility of Bufei Yishen Formula Alleviates Alveolar Epithelial Barrier Damage in COPD Through Inhibition of p38 MAPK Phosphorylation. [PDF]

Int J Chron Obstruct Pulmon Dis
Shao X, Zhang L, Guo M, Wang C, Chu H, Mo Y, Lu R, Zhao P, Tian Y.   +8 more
europepmc   +1 more source