Results 111 to 120 of about 43,361 (299)

Effect of E2 on occludin and claudin-1. [PDF]

open access: yes, 2016
(A) Immunoblots of occludin and (B) claudin-1 protein from Huh7.5 cells treated with 10 μM E2. (C) Expression of HCV receptors occludin, claudin-1 and SR-B1 in Huh7.5 cells treated with increasing amounts of E2 or (D) G1.
Manuel M. Lafer (843502)   +5 more
core   +1 more source

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

open access: yesAdvanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin   +13 more
wiley   +1 more source

Occludin gene expression in human NEC versus control mucosa. [PDF]

open access: yes, 2014
(A) We measured gene expression levels of occluding by quantitative RT-PCR in 16 NEC tissue sections and 13 controls by quantitative RT-PCR array.
Jörn-Hendrik Weitkamp (218989)   +10 more
core   +1 more source

Dielectric Elastomer Actuators as Safe and Effective Tools for Mechanostimulation of Human Cells

open access: yesAdvanced Intelligent Systems, EarlyView.
Replicating physiological forces is crucial for realistic cell models. Dielectric elastomer actuators (DEAs) offer a soft alternative, though their high voltages raised toxicity concerns. We demonstrate that DEA stimulation causes no cell damage, cell death or cell‐cycle disruption, while activating mechanosensitive responses.
Simon Holzer   +6 more
wiley   +1 more source

Occludin dephosphorylation in early development of Xenopus laevis [PDF]

open access: yes, 1997
Using immunoblot and immunofluorescence analysis with a cross-reacting antiserum, we identified Xenopus laevis occludin as a 57-61 kDa antigen colocalized with cingulin in epithelial junctions of embryos.
DE RIGO L.   +5 more
core  

Occludin Content Modulates Hydrogen Peroxide–Induced Increase in Renal Epithelial Paracellular Permeability [PDF]

open access: yes, 2016
The ability of hydrogen peroxide (H2O2) to increase paracellular permeability of renal epithelial cell monolayers was examined and the role of occludin in this regulation was investigated.
Amsler, Kurt   +3 more
core   +1 more source

Mesoporous Silica Nanoparticles With Customized Drug Ratio/Loading for Effective Treatment of Gemcitabine‐Resistant Pancreatic Tumors

open access: yesAdvanced NanoBiomed Research, EarlyView.
Redox responsive mesoporous silica nanoparticles (MSNs) were engineered to deliver gemcitabine (Gem) and cisplatin (cisPt) at defined ratios to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Optimized Gem MSNs and Gem cisPt MSNs enhanced cytotoxicity in murine and human Gem resistant models, with select formulations inducing ...
Tamanna Binte Huq   +5 more
wiley   +1 more source

Capsaicin decreases occludin protein content and the protein-protein interactions involving occludin in TJ. [PDF]

open access: yes, 2013
(A,B) MDCK monolayers were exposed to ethanol control or 300 µM capsaicin for 45 min. (A) The cellular localization of the TJ proteins occludin and claudin-1 was examined by immunofluorescence. Scale bar: 10 µm.
Hiroko Isoda (486330)   +4 more
core   +1 more source

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

open access: yesAnimal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao   +6 more
wiley   +1 more source

Reduction of Ribonucleotide Reductase Subunit RRM2 Potentially Impairs Gut Function of Woody Breast Broilers

open access: yesAnimal Research and One Health, EarlyView.
Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri   +8 more
wiley   +1 more source

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