Results 101 to 110 of about 43,361 (299)

Protective effect of bile acids on the onset of fructose-induced hepatic steatosis in mice

Journal of Lipid Research, 2010
Fructose intake is being discussed as a key dietary factor in the development of nonalcoholic fatty liver disease (NAFLD). Bile acids have been shown to modulate energy metabolism. We tested the effects of bile acids on fructose-induced hepatic steatosis.
Valentina Volynets, Astrid Spruss, Giridhar Kanuri, Sabine Wagnerberger, Stephan C. Bischoff, Ina Bergheim   +5 more
doaj   +1 more source

TNFα alters occludin and cerebral endothelial permeability: Role of p38MAPK. [PDF]

, 2017
Occludin is a key tight junction (TJ) protein in cerebral endothelial cells (CECs) playing an important role in modulating blood-brain barrier (BBB) functions.
James C Lee, Grace Y. Sun (36988), James C. Lee (277043), Agnes Simonyi (36987), Runting Li (3723301), Tao Teng (3723298), Runting Li, James C. Lee, Yawen Ni, Grace Y. Sun, Grace Y Sun, Agnes Simonyi, Tao Teng, Yawen Ni (3723304)   +13 more
core   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Acute exposure to 27.12 MHz radiofrequency electromagnetic field disrupts blood-brain barrier integrity via eNOS activation and occludin down-regulation [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Controlled modulation of blood-brain barrier (BBB) permeability without inducing damage represents a promising strategy for enhancing central nervous system drug delivery.Materials and Methods: This study investigated the effects of 27.12 ...
Arzu Ulusoy, Halil Asci, Rumeysa Taner, Muhammet Tepebasi, Ilter Ilhan, Pinar Karabacak, Selcuk Comlekci, Ozlem Ozmen   +7 more
doaj   +1 more source

Occludin is required for cytokine-induced regulation of tight junction barriers [PDF]

, 2010
The function of occludin remains elusive. Proposed roles include maintenance of tight junction barriers, signaling and junction remodeling. To investigate a potential role in mediating cytokine-induced changes in barrier properties, we measured barrier ...
Christina M. Van Itallie, James M. Anderson, Fanning, Alan S., Jennifer Holmes, Van Itallie, Christina M., Holmes, Jennifer, Anderson, James M., Alan S. Fanning   +7 more
core   +2 more sources

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

Advanced Science, EarlyView.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang, Liucan Wang, Guoqing Chen, Yuanling Zhang, Jiarui Shi, Wenzhe Fan, Min Yu, Jixi Zhang, Hua Yang   +8 more
wiley   +1 more source

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease

Advanced Science, EarlyView.
An orally administered prebiotic polysaccharide hydrogel (predaGel) based on inulin and alginate‐dopamine is stable in the stomach, adheres to the intestine, and degrades slowly in the colon. It enables site‐specific delivery of anti‐TNF‐α and anti‐IL‐12/23 antibodies, scavenges reactive oxygen species, and remodels gut microbiota, offering effective ...
Xinyi Dong, Huan He, Li Cao, Fenghua Meng, Zhiyuan Zhong   +4 more
wiley   +1 more source

Bibliometric Analysis of the Role of Occludin in the Pathogenesis of Stroke

Oxidative Medicine and Cellular Longevity
Over the past decade, there has been a notable surge in research dedicated to unraveling the intricate role of tight junction proteins in blood–brain barrier (BBB) damage associated with ischemic stroke. This bibliometric analysis explores the expansive landscape of occludin research, a key tight junction protein, during the years 2000–2023, shedding ...
Zhanylsyn U. Urasheva, Gulnar B. Kabdrakhmanova, Aigul P. Yermagambetova, Aigerim B. Utegenova, Nazgul A. Seitmaganbetova, Ondassyn M. Aliyev, Saulesh S. Kurmangaliyeva, Nazym K. Kenzhina, Yergen Z. Kurmambayev, Alima A. Khamidulla   +9 more
openaire   +2 more sources

Occludin expression inhibits tumorigenicity and metastasis

The FASEB Journal, 2006
Occludin is the first identified integral protein for tight junction (TJ), and its long C‐terminal domain is considered to have functions in receiving or transmitting cell survival signals. Loss of TJ‐associated molecules such as occludin has been correlated with tumor progression in carcinogenesis: however, the precise molecular mechanisms explaining ...
Makoto Osanai, Nami Nishikiori, Masaki Murata, Hideki Chiba, Takashi Kojima, Norimasa Sawada   +5 more
openaire   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source