Results 81 to 90 of about 46,424 (193)

Diesel exhaust particles modulate the tight junction protein occludin in lung cells in vitro [PDF]

, 2009
: BACKGROUND: Using an in vitro triple cell co-culture model consisting of human epithelial cells (16HBE14o-), monocyte-derived macrophages and dendritic cells, it was recently demonstrated that macrophages and dendritic cells create a transepithelial ...
Rothen-Rutishauser, Barbara M, Peter Gehr, Andrea D Lehmann, Barbara M Rothen-Rutishauser, Baum, Oliver, Blank, Fabian, Fabian Blank, Oliver Baum, Gehr, Peter, Lehmann, Andrea D   +9 more
core   +2 more sources

New Postbiotic Derived from Sequential Fermentation of Two Lacticaseibacillus Strains Exerts Beneficial Effects on Epithelial Gut Barrier and Innate Immunity in Human Enterocytes

Microorganisms
The efficacy of postbiotics varies significantly between different strains and preparation processes. We aimed at evaluating the effect of an innovative postbiotic product (iPB) generated through the sequential fermentation of Lacticaseibacillus ...
Franca Oglio, Alessia Cadavere, Monia De Aloe, Anna Lintura, Marco Michelini, Chiara Luongo, Serena Coppola, Alessandra Agizza, Erika Caldaria, Laura Carucci   +9 more
doaj   +1 more source

Effects of Claudin-1 on the Action of Clostridium perfringens Enterotoxin in Caco-2 Cells

Toxins, 2019
Clostridium perfringens enterotoxin (CPE) contributes to diarrhea and an often-lethal enterotoxemia. CPE action starts when it binds to claudin receptors, forming a small complex (90 kDa). Six small complexes then oligomerize to create prepores, followed
Iman Mehdizadeh Gohari, Jihong Li, Mauricio Navarro, Francisco Uzal, Bruce McClane   +4 more
doaj   +1 more source

A novel basolateral type IV secretion model for the CagA oncoprotein of Helicobacter pylori

Microbial Cell, 2017
Intercellular junctions are crucial structural elements for the formation and maintenance of epithelial barrier functions to control homeostasis or protect against intruding pathogens in humans.
Silja Wessler, Steffen Backert
doaj   +1 more source

Occludin expression inhibits tumorigenicity and metastasis

The FASEB Journal, 2006
Occludin is the first identified integral protein for tight junction (TJ), and its long C‐terminal domain is considered to have functions in receiving or transmitting cell survival signals. Loss of TJ‐associated molecules such as occludin has been correlated with tumor progression in carcinogenesis: however, the precise molecular mechanisms explaining ...
Makoto Osanai, Nami Nishikiori, Masaki Murata, Hideki Chiba, Takashi Kojima, Norimasa Sawada   +5 more
openaire   +1 more source

Oleoylethanolamide supplementation enriches Akkermansia muciniphila and modulates intestinal barrier function in adults with obesity: A randomized, double-blind, placebo-controlled trial

Gut Microbes Reports
Targeted modulation of the gut microbiome represents a promising nutritional strategy to support metabolic and intestinal health in overweight and obese adults.
Romeo Batacan, Amanda Rao, Yadav Sharma Bajagai, Dragana Stanley, David Briskey   +4 more
doaj   +1 more source

Bibliometric Analysis of the Role of Occludin in the Pathogenesis of Stroke

Oxidative Medicine and Cellular Longevity
Over the past decade, there has been a notable surge in research dedicated to unraveling the intricate role of tight junction proteins in blood–brain barrier (BBB) damage associated with ischemic stroke. This bibliometric analysis explores the expansive landscape of occludin research, a key tight junction protein, during the years 2000–2023, shedding ...
Zhanylsyn U. Urasheva, Gulnar B. Kabdrakhmanova, Aigul P. Yermagambetova, Aigerim B. Utegenova, Nazgul A. Seitmaganbetova, Ondassyn M. Aliyev, Saulesh S. Kurmangaliyeva, Nazym K. Kenzhina, Yergen Z. Kurmambayev, Alima A. Khamidulla   +9 more
openaire   +2 more sources

Occludin is required for cytokine-induced regulation of tight junction barriers [PDF]

, 2010
The function of occludin remains elusive. Proposed roles include maintenance of tight junction barriers, signaling and junction remodeling. To investigate a potential role in mediating cytokine-induced changes in barrier properties, we measured barrier ...
Christina M. Van Itallie, James M. Anderson, Fanning, Alan S., Jennifer Holmes, Van Itallie, Christina M., Holmes, Jennifer, Anderson, James M., Alan S. Fanning   +7 more
core   +1 more source

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science
Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gastrointestinal tract. This disease is characterized by a steadily increasing global incidence.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
doaj   +1 more source

Upregulation of Intestinal Barrier Function in Mice with DSS-Induced Colitis by a Defined Bacterial Consortium Is Associated with Expansion of IL-17A Producing Gamma Delta T Cells

Frontiers in Immunology, 2017
Bacterial consortium transplantation (BCT) is a promising alternative to fecal microbiota transplantation in treating inflammatory bowel disease (IBD). Here, we showed that a defined bacterial consortium derived from healthy mice was able to enhance the ...
Ming Li, Bing Wang, Xiaotong Sun, Yan Tang, Xiaoqing Wei, Biying Ge, Yawei Tang, Ying Deng, Chunyang He, Jieli Yuan, Xia Li   +10 more
doaj   +1 more source