Results 91 to 100 of about 43,361 (299)

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

Selected Serum Biomarkers in Patients with Relapsing-Remitting Multiple Sclerosis—A 3-Year Prospective Pilot Study

Medical Sciences
Background: The aim of this study was to evaluate the significance of serum concentrations of the inflammatory marker osteopontin, the blood–brain barrier damage marker occludin, and the neurodegeneration marker neurofilament light chain (NFL) in ...
Przemyslaw Puz, Katarzyna Maciejowska, Daria Gendosz de Carrillo, Malgorzata Janik, Anetta Lasek-Bal   +4 more
doaj   +1 more source

A Microgel Platform Enables Site‐Specific Intestinal Delivery of Lactoferrin, Improving its Bioavailability for Targeted Alleviating Liver Injury and Colitis

Advanced Science, EarlyView.
This work first time reports an eco‐friendly desert plant food‐based polysaccharide ASKP microgels which have intestinal site‐specific release properties which can achieve small‐intestine or colon targeting capability via different cross‐linking chemistry.
Huiling Yan, Yixuan Li, Shanan Chen, Pengcheng Du, Kaiwen Wu, Hui Zhang, Kasper Hettinga, Lina Zhang, Gergely Toldi, Fazheng Ren, Yuan Li   +10 more
wiley   +1 more source

Altered Expression of Intestinal Tight Junctions in Patients with Chronic Kidney Disease: A Pathogenetic Mechanism of Intestinal Hyperpermeability

Biomedicines
Background: Systemic inflammation in chronic kidney disease (CKD) is associated (as a cause or effect) with intestinal barrier dysfunction and increased gut permeability, with mechanisms not yet fully understood.
Georgia-Andriana Georgopoulou, Marios Papasotiriou, Pinelopi Bosgana, Anne-Lise de Lastic, Eleni-Evangelia Koufou, Evangelos Papachristou, Dimitrios S. Goumenos, Periklis Davlouros, Eleni Kourea, Vasiliki Zolota, Konstantinos Thomopoulos, Athanasia Mouzaki, Stelios F. Assimakopoulos   +12 more
doaj   +1 more source

Tight Junctions Go Viral!

Viruses, 2015
Tight junctions (TJs) are highly specialized membrane domains involved in many important cellular processes such as the regulation of the passage of ions and macromolecules across the paracellular space and the establishment of cell polarity in ...
Jesús M. Torres-Flores, Carlos F. Arias
doaj   +1 more source

An Edible Biohybrid Platform Accomplishes In Situ Fenton‐Mediated Enteral Nanoplastics Aging and Excretion

Advanced Science, EarlyView.
An edible biohybrid platform triggers nanoplastics (NPs) aging and agglomeration by in situ generating hydroxyl radicals within the intestine. The enlarged NPs are unable to penetrate the intestine and are subsequently excreted. Simultaneously, probiotic biofilms reinforce the intestinal barrier.
Su Zhou, Anran Yan, Haowei Guo, Ping Chen, Qiang Chu   +4 more
wiley   +1 more source

Effects and underlying mechanisms of ginsenoside Rb1 in improving non-alcoholic steatohepatitis via modulation of the gut-liver axis

陆军军医大学学报
Objective To investigate the therapeutic effects of ginsenoside Rb1 on non-alcoholic steatohepatitis (NASH) and its mechanisms through modulating gut microbiota and repairing intestinal barriers in liver inflammation and metabolic disorders. Methods
FU Hui, FU Hui, XU Benjin
doaj   +1 more source

The Role of Occludin in Vascular Endothelial Protection

, 2023
Endothelial tight junction proteins play an important role in maintaining the integrity of vascular endothelial structure and physiological function. In recent years, studies have found that alterations in the expression, distribution, and structure of endothelial tight junction proteins may lead to many related vascular diseases and pathologies (such ...
Yunhui Du, Yanru Duan, Shihan Zhang
openaire   +1 more source

Neurons and ECM regulate occludin localization in brain endothelial cells [PDF]

, 2000
We report that extracellular matrix and neurons modulate the expression of occludin, one of the main components of tight junctions, by rat brain endothelial cells (RBE4.B).
Savettieri G., Licata L., Giandalia G., Pitarresi G. L., Giannola L. I., Catania C., De Caro V., Di Liegro I., D'Agostino S., Cestelli A., Schiera G.   +10 more
core   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source