Results 91 to 100 of about 56,078 (308)
Anthocyanins protect the gastrointestinal tract from high fat diet-induced alterations in redox signaling, barrier integrity and dysbiosis. [PDF]
, 2019 The gastrointestinal (GI) tract can play a critical role in the development of pathologies associated with overeating, overweight and obesity. We previously observed that supplementation with anthocyanins (AC) (particularly glycosides of cyanidin and ...
Adamo, Ana M +9 more
core +2 more sources
Loss of occludin leads to the progression of human breast cancer [PDF]
International Journal of Molecular Medicine, 2010 Occludin is an integral membrane protein localised at tight junctions (TJs). It has become clear that the TJ is an important structure that cancer cells must overcome in order to metastasize successfully. The purpose of this study was to elucidate the importance of the expression of occludin in human breast cancer.
Martin, Tracey Amanda +2 more
openaire +3 more sources
Advanced Science, EarlyView.This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley +1 more source
Advanced Science, EarlyView.Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia +4 more
wiley +1 more source
Medical SciencesBackground: The aim of this study was to evaluate the significance of serum concentrations of the inflammatory marker osteopontin, the blood–brain barrier damage marker occludin, and the neurodegeneration marker neurofilament light chain (NFL) in ...
Przemyslaw Puz +4 more
doaj +1 more source
Protective effect of bile acids on the onset of fructose-induced hepatic steatosis in mice
Journal of Lipid Research, 2010 Fructose intake is being discussed as a key dietary factor in the development of nonalcoholic fatty liver disease (NAFLD). Bile acids have been shown to modulate energy metabolism. We tested the effects of bile acids on fructose-induced hepatic steatosis.
Valentina Volynets +5 more
doaj +1 more source
Cytokine tuning of intestinal epithelial function [PDF]
, 2018 The intestine serves as both our largest single barrier to the external environment and the host of more immune cells than any other location in our bodies.
Andrews, Caroline +2 more
core +4 more sources
Advanced Science, EarlyView.Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong +21 more
wiley +1 more source
BiomedicinesBackground: Systemic inflammation in chronic kidney disease (CKD) is associated (as a cause or effect) with intestinal barrier dysfunction and increased gut permeability, with mechanisms not yet fully understood.
Georgia-Andriana Georgopoulou +12 more
doaj +1 more source
Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions. [PDF]
, 2020 Polarized distribution of organelles and molecules inside a cell is vital for a range of cellular processes and its loss is frequently encountered in disease.
Choi, Julie +6 more
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