Results 71 to 80 of about 46,424 (193)

Effects and underlying mechanisms of ginsenoside Rb1 in improving non-alcoholic steatohepatitis via modulation of the gut-liver axis

陆军军医大学学报
Objective To investigate the therapeutic effects of ginsenoside Rb1 on non-alcoholic steatohepatitis (NASH) and its mechanisms through modulating gut microbiota and repairing intestinal barriers in liver inflammation and metabolic disorders. Methods
FU Hui, FU Hui, XU Benjin
doaj   +1 more source

Protective effect of bile acids on the onset of fructose-induced hepatic steatosis in mice

Journal of Lipid Research, 2010
Fructose intake is being discussed as a key dietary factor in the development of nonalcoholic fatty liver disease (NAFLD). Bile acids have been shown to modulate energy metabolism. We tested the effects of bile acids on fructose-induced hepatic steatosis.
Valentina Volynets, Astrid Spruss, Giridhar Kanuri, Sabine Wagnerberger, Stephan C. Bischoff, Ina Bergheim   +5 more
doaj   +1 more source

Zonula occludin toxin, a microtubule binding protein

World Journal of Gastroenterology, 2000
AIM:To investigate the interaction of Zot with microtubule.METHODS:Zot affinity column was applied to purify Zot-binding protein(s) from crude intestinal cell lysates. After incubation at room temperature, the column was washed and the proteins bound to the Zot affinity column were eluted by step gradient with NaCl (0.3molcenter dotL(-1) -0.5molcenter ...
Wen-Le, Wang, Rui-Liang, Lu, MariaRosaria, DiPierro, Alessio, Fasano   +3 more
openaire   +2 more sources

Connexin-Occludin Chimeras Containing the Zo-Binding Domain of Occludin Localize at Mdck Tight Junctions and Nrk Cell Contacts [PDF]

The Journal of Cell Biology, 1999
Occludin is a transmembrane protein of the tight junction that functions in creating both an intercellular permeability barrier and an intramembrane diffusion barrier. Creation of the barrier requires the precise localization of occludin, and a distinct family of transmembrane proteins called claudins, into continuous linear fibrils visible by freeze ...
L L, Mitic, E E, Schneeberger, A S, Fanning, J M, Anderson   +3 more
openaire   +2 more sources

Acute exposure to 27.12 MHz radiofrequency electromagnetic field disrupts blood-brain barrier integrity via eNOS activation and occludin down-regulation [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Controlled modulation of blood-brain barrier (BBB) permeability without inducing damage represents a promising strategy for enhancing central nervous system drug delivery.Materials and Methods: This study investigated the effects of 27.12 ...
Arzu Ulusoy, Halil Asci, Rumeysa Taner, Muhammet Tepebasi, Ilter Ilhan, Pinar Karabacak, Selcuk Comlekci, Ozlem Ozmen   +7 more
doaj   +1 more source

Das Zusammenspiel zwischen Occludin und ZO-1 ist redox-empfindlich

, 2011
1\. Introduction .......................................................................................................................................
Castro Villela, Víctor Manuel
core   +1 more source

Ang-1 diminishes thrombin mediated tyrosine phosphorylation of Occludin.

, 2015
(A) Serum starved HBMECs were treated with 100nM thrombin for indicated time periods. Cellular proteins were immunoprecipitated with anti-Occludin antibody followed by immunoblotting using anti-PY-20 antibody.
M. Rizwan Siddiqui (757691), Kwang Sik Kim (18727), Tadanori Tomita (198796), Chandra S. Mayanil (757692)   +3 more
core   +1 more source

JNK inhibition prevents loss of occludin.

, 2013
Occludin concentration in cell monolayers significantly drops following 60 minutes of stretch (0.25 Hz, 37% ΔSA) compared to unstretched monolayers ...
Gladys Gray Lawrence (157183), Amit Khasgiwala (365311), Susan S. Margulies (157185), Taylor S. Cohen (157180)   +3 more
core   +1 more source

Arsenic exposure results in differential phosphorylation of occludin.

, 2013
Occludin protein levels were significantly increased following a 5-day arsenic exposure that was coincident with an increased phosphorylation state seen most prominently in the banding pattern of the 3.9 μM As-treated cultures.
R. Clark Lantz (494123), Jefferey L. Burgess (65119), Andrew E. Liguori (494121), Scott Boitano (494124), Colin E. Olsen (494122), Cara L. Sherwood (494120)   +5 more
core   +1 more source

MMP-9 activation mediated by E2 modulates occludin.

, 2016
(A) Immunoblot of occludin down-regulation by G1, reversed by ONO-4817 (ONO). Protein expression relative to GAPDH was quantitated in a SyngeneG:box (right).
Manuel M. Lafer (843502), Nicoleta Cehan (843504), Laura Ulitzky (248632), Deborah R. Taylor (248652), Mark A. KuKuruga (843503), Erica Silberstein (248622)   +5 more
core   +1 more source