Results 111 to 120 of about 6,483 (202)

Correlation between inhibition of OCT2-mediated metformin, MPP⁺, and ASP⁺ uptake in HEK-OCT2 cells.

, 2015
(A) Shown are drugs which were tested for each of the three substrates (n = 75). Drugs were tested at 20 μM. The size of the balls represents the inhibition of ASP+ uptake. Black balls, positive values; white balls, negative values.
Kristina Hacker (773425), Martin F. Fromm (526796), Johannes Kornhuber (44072), Renke Maas (453805), Oliver Zolk (526793)   +4 more
core   +1 more source

Response to Comment on “Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin”

, 2017
OCT2 plays a key role in synergy between decitabine and oxaliplatin in renal cell carcinoma cell lines.
Hua Wang, Qinqin Yu, Xiaoli Zheng, Lushan Yu, Huidi Jiang, Su Zeng, Yanqing Liu, Fuqing Tan, Qianying Zhu, Lingmin Yuan   +9 more
core   +1 more source

Renoprotective action of rabeprazole and lansoprazole in gentamicin-induced nephrotoxicity: roles of oxidative stress, apoptosis, ER stress, and OCT2 expression

Future Journal of Pharmaceutical Sciences
Background Gentamicin (GNT)-induced nephrotoxicity involves oxidative stress, apoptosis, and enhanced renal accumulation, partly mediated by OCT2 transport activity.
Khalid AlAzmi, Rehab M. Khedr, Elsayed K. El-Sayed, Mohamad Elbaz   +3 more
doaj   +1 more source

Comparison of the inhibition of OCT2-mediated MPP⁺ uptake by the metabolites at multiple concentration ranges.

, 2012
(A) Inhibitory effect of TEA (0.1–1000 mM), glycine (1–100 mM), taurine (1–100 mM), L-tryptophan (0.01–10 mM), and uridine (1–100 mM) on OCT2-mediated MPP+ uptake.
Hyunmi Kim (156020), Inmyoung Park (166766), Oliver Fiehn (17098), Jae-Gook Shin (166770), Yun Gyong Ahn (166763), Kwang-Hyeon Liu (166773), Do Yup Lee (166755), Kyoung Heon Kim (166768), Im-Sook Song (166751), Min-Hye Shin (166758), Tobias Kind (17097)   +10 more
core   +1 more source

Efficient proximal tubule-on-chip model from hiPSC-derived kidney organoids for functional analysis of renal transporters

iScience
Summary: Renal transporters play critical roles in predicting potential drug-drug interactions. However, current in vitro models often fail to adequately express these transporters, particularly solute carrier proteins, including organic anion ...
Cheng Ma, Ramin Banan Sadeghian, Ryosuke Negoro, Kazuya Fujimoto, Toshikazu Araoka, Naoki Ishiguro, Minoru Takasato, Ryuji Yokokawa   +7 more
doaj   +1 more source

Abstract 1521: Influence of Oct1/Oct2-deficiency on cisplatin-induced changes in urinary N-acetyl-β-D-glucosaminidase

, 2010
Cisplatin is among the most widely used anticancer drugs and known to cause dose-limiting nephrotoxicity. We recently reported that renal organic cation transporters (OCT2 in humans, Oct1 and Oct2 in mice) are involved in the urinary excretion and ...
Ryan M. Franke, Kelly K. Filipski, Ashley M. Kosloske, Alex Sparreboom   +3 more
core   +1 more source

OCT2 demethylation cracks open oxaliplatin resistance [PDF]

Nature Reviews Nephrology, 2016
openaire   +1 more source

Identification of Brimonidine as a Novel Substrate of Organic Cation Transporters OCT2 and MATE1 Expressed in Human Eye. [PDF]

Invest Ophthalmol Vis Sci
Kölz C, Neul C, Hofmann U, Dressler JC, Süsskind D, Wissinger B, Schwab M, Nies AT.   +7 more
europepmc   +1 more source

Incidence and Magnitude of Pseudo-decrease in Kidney Function With Oral Epidermal Growth Factor Inhibitor Osimertinib. [PDF]

Kidney Med
Ilyas M, Nguyen J, Shettigar S, LeClaire J, Mathavan A, Mathavan A, Shah CV.   +6 more
europepmc   +1 more source

Regulation of Human Renal Transporters by Pregnancy-Related Hormones in Primary Proximal Tubular Epithelial Cells. [PDF]

Metabolites
Tsang YP, Wang K, Kelly EJ, Mao Q, Unadkat JD.   +4 more
europepmc   +1 more source