Results 91 to 100 of about 6,483 (202)

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

VIEW, Volume 7, Issue 3, June 2026.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai, Tianming Peng, Zhiyue Xie, Chuqian Zhen, Chen Yao, Nan Peng, Qianyi Li, Yuzhong Yu, Jiming Bao, Xian‐Lu Song, Mingkun Chen, Shan‐Chao Zhao   +11 more
wiley   +1 more source

OCT2, SSX and SAGE1 reveal the phenotypic heterogeneity of spermatocytic seminoma reflecting distinct subpopulations of spermatogonia.

, 2011
Spermatocytic seminoma (SS) is a rare testicular neoplasm that occurs predominantly in older men. In this study, we aimed to shed light on the histogenesis of SS by investigating the developmental expression of protein markers that identify distinct ...
Rajpert-De Meyts, E, Rajpert-De Meyts, Ewa, Ewen, Katherine A, Jacobsen, GK, Graem, Niels, Katherine A Ewen, Lim, J, Andrew OM Wilkie, Jacobsen, Grete Krag, Gareth DH Turner, Jasmine Lim, Ewa Rajpert‐De Meyts, Wilkie, Andrew Om, Grete Krag Jacobsen, Ewen, KA, Goriely, Anne, Turner, Gareth Dh, Anne Goriely, Lim, Jasmine, Goriely, A, Turner, GD, Graem, N, Niels Graem, Wilkie, AO   +23 more
core   +1 more source

Evaluation of the in vitro otoprotective potential of 4-aminopyridine for cisplatin-induced ototoxicity

Frontiers in Audiology and Otology
BackgroundCisplatin, an effective chemotherapy, is a cause of ototoxicity. It enters inner ear cells through Organic Cation Transporter 2 (OCT2). Recently, we identified another cochlear transporter, Multidrug and Toxin Extrusion Protein 1 (MATE1); it ...
Sofia Waissbluth, Cindel Figueroa-Cares, Cindel Figueroa-Cares, Helmuth A. Sánchez, Agustin Demetrio Martinez, Agustin Demetrio Martinez   +5 more
doaj   +1 more source

Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients

, 2012
Purpose: Knowledge of transporters responsible for the renal secretion of creatinine is key to a proper interpretation of serum creatinine and/or creatinine clearance as markers of renal function in cancer patients receiving chemotherapeutic agents ...
Ciarimboli, G. (Giuliano), Franke, R.M. (Ryan), Yang, W. (Wenjian), Sparreboom, A. (Alex), Relling, M.V. (Mary), Mathijssen, A.H.J. (Ron), Pavenstädt, H. (Hermann), Lancaster, C.S. (Cynthia), Guckel, D. (Denise), Pui, C.H. (Ching-Hon), Schlatter, E. (Eberhard), Herrmann, E. (Eva), Sprowl, J.A. (Jason), Massmann, V. (Vivian)   +13 more
core   +2 more sources

Relevance of Copper and Organic Cation Transporters in the Activity and Transport Mechanisms of an Anticancer Cyclometallated Gold(III) Compound in Comparison to Cisplatin

Frontiers in Chemistry, 2018
The molecular mechanisms of toxicity and cellular transport of anticancer metallodrugs, including platinum-based agents, have not yet been fully elucidated.
Sarah Spreckelmeyer, Sarah Spreckelmeyer, Margot van der Zee, Benoît Bertrand, Benoît Bertrand, Ewen Bodio, Stefan Stürup, Angela Casini, Angela Casini   +8 more
doaj   +1 more source

Differential tryptophan uptake rate in oocytes overexpressing the OCT2 reference and 808G>T variant.

, 2012
Uptake of (A) 100 nM [3H]tryptophan or (B) 18.5 nM [3H]MPP+ by oocytes overexpressing the OCT2 reference or 808G>T variant. Defolliculated oocytes were injected with 50 ng of capped cRNA and incubated for 2 days. Uptake was measured for 30 min.
Hyunmi Kim (156020), Inmyoung Park (166766), Oliver Fiehn (17098), Jae-Gook Shin (166770), Yun Gyong Ahn (166763), Kwang-Hyeon Liu (166773), Do Yup Lee (166755), Kyoung Heon Kim (166768), Im-Sook Song (166751), Min-Hye Shin (166758), Tobias Kind (17097)   +10 more
core   +1 more source

EBV Positive Diffuse Large B Cell Lymphoma with Negative Pan-B Cell Markers, Case Report, and Literature Review

Case Reports in Hematology
Most B cell lymphomas are positive for one or more B cell markers including CD19, CD20, CD79a, or PAX5. However, rare cases of mature B cell lymphoma not expressing any B cell markers have been characterized and recognized as distinct diagnostic entities
Janna Shold, Lea Jukic, Daniel Farrell, Wei Cui, Da Zhang   +4 more
doaj   +1 more source

Hormonal regulation of organic cation transporter OCT2 expression in rat kidney

FEBS Letters, 2000
Rat (r) OCT2 was identified as the second member of the organic cation transporter (OCT) family, and is predominantly expressed in the kidney. We reported previously that rOCT2 was responsible for the gender differences in renal basolateral membrane organic cation transport activity.
Urakami, Yumiko, Okuda, Masahiro, Saito, Hideyuki, Inui, Ken-ichi   +3 more
openaire   +2 more sources

Fluorocholine transport mediated by the organic cation transporter 2 (OCT2,SLC22A2): implication for imaging of kidney tumors

, 2018
[18F]fluorocholine is the fluorinated analogue of [11C]choline and is used in positron emission tomography (PET) to monitor tumor metabolic activity. While important to optimize its use and expand the clinical indications, the molecular determinants of ...
Hausler, Stephanie, Peter H. Schraml, Zhibo Gai, Chao Li, Visentin, Michele, Hiller, Christian, Schraml, Peter H, Angelo Torozi, Stephanie Häusler, Gerd A. Kullak-Ublick, Torozi, Angelo, Moch, Holger, Christian Hiller, Michele Visentin, Li, Chao, Kullak-Ublick, Gerd A, Gai, Zhibo, Holger Moch   +17 more
core   +1 more source

Rapidly Progressive Cutaneous Nodules in an Elderly Woman

JEADV Clinical Practice, Volume 5, Issue 2, Page 737-741, June 2026.
Valeria Olvera‐Rodriguez, Gerardo González‐Martínez, Marion Carolina Alemán‐Jiménez, Minerva Gómez‐Flores, Jorge Ocampo‐Candiani, Lucía T. Fernández   +5 more
wiley   +1 more source