Results 81 to 90 of about 6,483 (202)

Gallic Acid‐Mediated Enhancement of Diazepam‐Induced Sedation via GABAA Receptor Modulation: In Vivo and In Silico Evaluation

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Gallic acid (GA) dose‐dependently reduced sleep latency and prolonged sleep duration in thiopental sodium‐induced mice, with synergistic effects when combined with diazepam. Molecular docking revealed GA's higher binding affinity (−9.8 kcal/mol) to GABAA receptor (α1 and β2 subunits) than diazepam (−8.4 kcal/mol), suggesting GABAergic potential ...
Noshin Tasnim Yana, Anike Chakrabarty, Chinmoy Kumar Saha, Nikhat Jamal Siddiqi, Norah Alnazhan, Md. Sakib Al Hasan, Feroz Khan Nun, Imam Hossen Rakib, Md. Nasimul Haque Shipon, Emon Mia, Md Asaduzzaman Jony, Ali Mohamod Wasaf Hasan, Muhammad Torequl Islam, Azmat Ali Khan   +13 more
wiley   +1 more source

An Unusual Case of Classic Hodgkin Lymphoma With Strong Expression of B‐Cell Markers

International Journal of Laboratory Hematology, EarlyView.
Christopher Liwski, Sorin Selegean, Allam Shawwa, David M. Conrad   +3 more
wiley   +1 more source

Potential of Aeginetia indica for Alzheimer's Disease Management: In Vitro, In Vivo, and Computational Insights

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
MeOH extract of Aeginetia indica (AİME); chromatographic study: LCMS/MS and GCMS; in vitro assays: AChE assays → ↓ AChE level, ↓ inflammation level and antioxidant assays → ROS; in vivo anti‐inflammatory study: ↓ inflammation level; molecular docking → molecular dynamics simulations: acacetin and acteoside.
Marjanur Rahman Bhuiyan, Md. Sharif Reza, Sadikur Rahman Shuvo, Mustafa Abdullah Yilmaz, Syed Mumtahin Mannan Siam, Md. Shadman Sakib, Oguz Cakir, Md. Nazmul Islam Durjoy, Abbas Tarhan, Nuraniye Eruygur, A. F. M. Shahid Ud Daula   +10 more
wiley   +1 more source

Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.

PLoS ONE, 2019
The effects of hyperuricemia on the expression of kidney drug transporters and on the pharmacokinetics of several substrate drugs were examined. We first established a rat model of hyperuricemia without marked symptoms of chronic kidney failure by 10-day
Kei Nishizawa, Noriaki Yoda, Fumi Morokado, Hisakazu Komori, Takeo Nakanishi, Ikumi Tamai   +5 more
doaj   +1 more source

Aberrant CD19 Expression on CD8‐Positive T‐Cell Lymphoma

International Journal of Laboratory Hematology, EarlyView.
Brian Vadasz, Yijie Liu, Qing Chen
wiley   +1 more source

The Role of Neutrophils and NETosis in Diseases: The Implications for Therapy

MedComm, Volume 7, Issue 6, June 2026.
Neutrophils secrete cytokines, express specific surface proteins, increase or decrease in cell count, and their ratio to lymphocyte count can be used as biomarkers to characterize collective status and disease progression. Neutrophils can monitor and track the body's health status, “Wei Bing” status, disease status, and different times of disease ...
Zhen Ma, Qing Wang, Yusheng Zhang, Yang Li, Hongwei Wu, Hongjun Yang, Xianyu Li   +6 more
wiley   +1 more source

Die Bedeutung des organischen Kationentransporters OCT2 für die Cisplatin-induzierte Ototoxizität

, 2010
Hintergrund: Für Tubuluszellen der Niere konnte in vitro gezeigt werden, dass der organische Kationentransporter 2 (OCT2) die Cisplatin-Aufnahme in die Zelle vermittelt.
Pavenstädt, H, Deuster, D, Knief, A, Edemir, B, am Zehnhoff-Dinnesen, A, Ciarimboli, G, Schinkel, AH, Jürgens, H, Schlatter, E, Lanvers-Kaminsky, C   +9 more
core   +1 more source

Encephalopathy: Cause, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv, Xia Zhong, Ruirui Shang, Linghui Kong, Yufei Huang, Yuexiang Ma, Jing Teng, Sheng Wei   +7 more
wiley   +1 more source

Supplementary Tables S1-S2, Figures S1-S8 from Targeting OCT2 with Duloxetine to Prevent Oxaliplatin-induced Peripheral Neurotoxicity

, 2022
Supplementary Table S1. Percentage of OCT2 inhibition by compounds reported to reduce platinum-induced toxicities. Supplementary Table S2. Validation of human, rat, and murine overexpressed cells by evaluating their ability to accumulate known ...
Shuiying Hu (15132390), Muhammad Erfan Uddin (15034434), Alex Sparreboom (15132393), Hanieh Taheri (15132381), Alice A. Gibson (15034428), Yan Jin (143500), Yang Li (15132384), Zahra Talebi (5624021), Maryam B. Lustberg (8809205), Duncan F. DiGiacomo (15132387), Mahesh R. Nepal (15132378)   +10 more
core   +1 more source

Impact of Viral Inflammation on the Expression of Renal Drug Transporters in Pregnant Rats

Pharmaceutics, 2019
Inflammation impacts the expression and function of drug transporters at term-gestation; however, the impact of inflammation on the expression of drug transporters at mid-gestation is largely unknown.
Navaz Karimian Pour, Eliza R. McColl, Micheline Piquette-Miller   +2 more
doaj   +1 more source