Results 71 to 80 of about 6,483 (202)

Kinetic basis of metformin-MPP interactions with organic cation transporter OCT2 [PDF]

American Journal of Physiology-Renal Physiology, 2019
Organic cation transporter 2 (OCT2) clears the blood of cationic drugs. Efforts to understand OCT2 selectivity as a means to predict the potential of new molecular entities (NMEs) to produce unwanted drug-drug interactions typically assess the influence of the NMEs on inhibition of transport.
Philip J. Sandoval, Mark Morales, Timothy W. Secomb, Stephen H. Wright   +3 more
openaire   +2 more sources

Conjunctive Therapy of Cisplatin With the OCT2 Inhibitor Cimetidine: Influence on Antitumor Efficacy and Systemic Clearance

, 2013
The organic cation transporter 2 (OCT2) regulates uptake of cisplatin in proximal tubules, and inhibition of OCT2 protects against severe cisplatin-induced nephrotoxicity.
Li, Li, Mathijssen, Ron; id_orcid, van Doorn, L, Mathijssen, Ron, Gerven, Leander, de Bruijn, Peter, Gibson, AA, Sprowl, JA, Sparreboom, A, Hu, S   +9 more
core   +1 more source

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Transport of Monoamine Transmitters by the Organic Cation Transporter Type 2, OCT2 [PDF]

Journal of Biological Chemistry, 1998
The recently cloned apical renal transport system for organic cations (OCT2) exists in dopamine-rich tissues such as kidney and some brain areas (Gründemann, D., Babin-Ebell, J., Martel, F., Ording, N., Schmidt, A., and Schömig, E. (1997) J. Biol. Chem. 272, 10408-10413).
D, Gründemann, S, Köster, N, Kiefer, T, Breidert, M, Engelhardt, F, Spitzenberger, N, Obermüller, E, Schömig   +7 more
openaire   +2 more sources

A lifespan staging model of basal forebrain cholinergic vulnerability

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract The cholinergic neurons of the basal forebrain are among the most vulnerable cell types to age‐ and Alzheimer's disease‐related dysfunction and neurodegeneration. However, the biological bases of basal forebrain cholinergic vulnerability (the why) and the temporal sequence (the how) have yet to be fully resolved.
Hayley R. C. Shanks, Sherry Chen, Kate M. Onuska, Taylor W. Schmitz   +3 more
wiley   +1 more source

Regulation of Solute Carriers OCT2 and OAT1/3 in the Kidney

Physiological Reviews, 2022
Over the course of more than 500 million years, the kidneys have undergone a remarkable evolution from primitive nephric tubes to intricate filtration-reabsorption systems that maintain homeostasis and remove metabolic end products from the body.
Pou Casellas, Carla, Jansen, Katja, Rookmaaker, Maarten B, Clevers, Hans, Verhaar, Marianne C, Masereeuw, Rosalinde   +5 more
openaire   +1 more source

Hyperreflective Foci in the Inner Nuclear Layer: Proof‐of‐Concept for an Optical Coherence Tomography Derived Microglia‐Related Marker in Multiple Sclerosis

Annals of Neurology, Volume 99, Issue 6, Page 1480-1485, June 2026.
The role of microglia has emerged as a critical driver of disease progression in multiple sclerosis (MS), but we lack broadly applicable monitoring tools. Here, we investigated whether hyperreflective foci (HRF), as detected by optical coherence tomography (OCT) within the inner nuclear layer (INL) of the retina, can be used as a marker for microglial ...
Jonathan A. Gernert, Laura M. Bartos, Tara Christmann, Hanna Zausinger, Luca N. Diedrich, Daniel Engels, Miriam Schlüter, Sarah Schlaeger, Sophia Stoecklein, Leonie F. Keidel, Tania Kümpfel, Martin Kerschensteiner, Matthias Brendel, Joachim Havla   +13 more
wiley   +1 more source

Identification of Target Genes of the Lymphoid-Specific Transcription Factor Oct2

Immunobiology, 1997
The Oct2 transcription factor is expressed predominantly in B lymphocytes and plays an essential role during the terminal phase of B cell differentiation. The regulatory regions of several genes specifically expressed in B cells contain functional binding sites for Oct2.
P, Pfisterer, J, Hess, T, Wirth
openaire   +2 more sources

In Silico Evaluation of 5‐Arylidine Glitazone Esters as Potential Antidiabetic Agents: ADMET, Molecular Docking, Dynamics, MMGBSA and DFT Studies

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
This study presents an in silico evaluation of 5‐Arylidine Glitazone Esters 3ai‐ev as Potential Antidiabetic Agents utilizing ADMET, Molecular Docking, Dynamics, MMGBSA, and DFT Studies. The drug‐like characteristics, safety, binding affinity, stability, free binding energy, and electronic properties of 31 compounds were investigated.
Kabelo P. Mokgopa, Mofeli B. Leoma, Tendamudzimu Tshiwawa, Ndivhuwo R. Tshiluka   +3 more
wiley   +1 more source

Bioenhancer‐Driven Modulation of Membrane Dynamics Improves B‐Vitamin Uptake in Caco‐2 Cells

ChemFoodChem, Volume 2, Issue 2, June 2026.
Natural bioenhancers such as extracts from ginger, turmeric, black pepper, and spearmint increase the uptake of vitamins B1, B5, B6, and B7 in Caco‐2 cells. Micellized formulations further increase efficacy. These findings indicate that altered membrane fluidity contributes to enhanced cellular absorption, providing a new route to improve vitamin B ...
Verena Preinfalk, Bernhard Blank‐Landeshammer, Marina Bishara, Sigrid Ihninger, Katja Essl, Stefanie Atzmüller, Mara Heckmann, Marcus Iken, Mario Brameshuber, Julian Weghuber   +9 more
wiley   +1 more source