Results 101 to 110 of about 6,483 (202)

Regulation of Solute Carriers OCT2 and OAT1/3 in the Kidney: A Phylogenetic, Ontogenetic and Cell Dynamic Perspective [PDF]

, 2022
Over the course of more than 500 million years, the kidneys have undergone a remarkable evolution from primitive nephric tubes to intricate filtration-reabsorption systems that maintain homeostasis and remove metabolic end products from the body.
Jansen, Katja, Clevers, Hans, Masereeuw, Rosalinde, Pou Casellas, Carla, Verhaar, Marianne C, Rookmaaker, Maarten B   +5 more
core  

Rescue of cart¹ phenotype by expressing human OCT2 in photoreceptors.

, 2016
(A) OCT2 was able to transport carcinine. S2 cells transiently expressed OCT2-mCherry in a culture medium to which carcinine was added at a final concentration of 20μM or 100 μM. Cells were immunolabeled with anti-carcinine (green), and the mCherry (red)
Futing An (841495), Jolanta A. Borycz (338019), Janusz Borycz (841496), Tao Wang (12008), Ying Xu (9172), Ian A. Meinertzhagen (46700)   +5 more
core   +1 more source

Assessing Substrate-Dependence and Mechanism of Ligand Interaction with the Organic Cation Transporter, OCT2

, 2018
Among its many functions, the kidney has a significant role in limiting the body’s exposure to potentially toxic xenobiotic compounds. One family of these compounds is designated as ‘organic cations’ (OCs); these are organic compounds that are ...
Sandoval, Philip Joseph
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Identification of single nucleotide polymorphisms within the OCT2 gene in the South African black population [PDF]

, 2016
A dissertation submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in fulfilment of requirements for the degree of Master of Science.
Wilson, Nina Claire
core  

Multiple Mechanisms of Ligand Interaction with the Human Organic Cation Transporter, OCT2

, 2013
OCT2 is the entry step for organic cation secretion by renal proximal tubules. Although many drugs inhibit OCT2 activity, neither the mechanistic basis of their inhibition nor their transport status is generally known.
Harper, Jaclyn Nicole
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Influence of Oct1/Oct2-Deficiency on Cisplatin-Induced Changes in Urinary N-Acetyl-β-D-Glucosaminidase

, 2010
Purpose: This study aimed to test the influence of functional renal organic cation transporters (OCT2 in humans, Oct1 and Oct2 in mice) on biomarkers of cisplatin nephrotoxicity, such as urinary activity of N-acetyl-β-D-glucosaminidase (NAG).
Mathijssen, Ron H; id_orcid, Kelly K. Filipski, Lancaster, Cynthia S, Chaoxin Hu, Filipski, Kelly K, Oliver Zolk, Franke, Ryan M, Ashley M. Kosloske, Ron H. Mathijssen, Sparreboom, Alex, Ryan M. Franke, Hu, Chaoxin, Kosloske, Ashley M, Mathijssen, Ron H, Cynthia S. Lancaster, Alex Sparreboom, Zolk, Oliver   +16 more
core   +1 more source

Comment on “Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin”

, 2017
Although the combination of decitabine and platinum drugs may be promising for therapy of renal cell carcinoma, the role of OCT2 needs further investigations.
Arnulf Stenzl, Anne T. Nies, Elke Schaeffeler, Matthias Schwab, Stefan Winter, Florian Büttner, Pascale Fisel, Jens Bedke   +7 more
core   +1 more source

Allele frequencies and genotype distribution of three metformin transporter polymorphisms in Mexican population and their application in pharmacogenomics of type 2 diabetes

Frontiers in Pharmacology
BackgroundMetformin is the first-line antidiabetic therapy for type 2 diabetes in Mexico, despite recent recommendations highlighting alternatives like GLP-1 receptor agonists for individuals with obesity.
Oscar I. Chávez-Arreola, Brissia Lazalde, Marisol López-López, Alberto Ortega-Vázquez, Alberto Ortega-Vázquez, Quitzia L. Torres-Salazar   +5 more
doaj   +1 more source

The importance of incorporating OCT2 plasma membrane expression and membrane potential in ivive of metformin renal secretory clearance S

, 2018
Copyright \ua9 2018 by The American Society for Pharmacology and Experimental Therapeutics. Transporter expression, determined by quantitative proteomics, together with PBPK models is a promising approach for in vitro-to-in vivo extrapolation (IVIVE) of ...
Kumar V, Prasad B, Unadkat JD, Brown CDA, Billington S, Wang J, Yin J   +6 more
core  

Transcriptional Coactivator BOB1 (OBF1, OCA-B) Modulates the Specificity of DNA Recognition by the POU-Domain Factors OCT1 and OCT2 in a Monomeric Configuration

Biomolecules
BOB1, a mammalian lymphocyte-specific transcriptional coactivator of the transcription factors OCT1 and OCT2 (OCT1/2), plays important roles in normal immune responses, autoimmunity, and hematologic malignancies.
Igor B. Nazarov, Danil S. Zilov, Mikhail N. Gordeev, Evgenii V. Potapenko, Nataliya Yeremenko, Alexey N. Tomilin   +5 more
doaj   +1 more source