Results 161 to 170 of about 6,483 (202)
OCT2 expression in histiocytoses
Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin, 2023 Diagnosis of histiocytosis can be difficult and one of the biggest challenges is to distinguish between reactive and neoplastic histiocytes on histology alone. Recently, OCT2 nuclear expression was reported in Rosai-Dorfman disease (RDD). Our purpose was to expand the testing of OCT2 on a broader variety of sporadic or H syndrome-related histiocytoses.
Irena Antonia Ungureanu +2 more
exaly +7 more sources
In Vitro Inhibition of Renal OCT2 and MATE1 Secretion by Antiemetic Drugs [PDF]
International Journal of Molecular Sciences, 2021 The organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1) mediate the renal secretion of drugs. Recent studies suggest that ondansetron, a 5-HT3 antagonist drug used to prevent nausea and vomiting, can inhibit OCT2- and MATE1-mediated transport. The purpose of this study was to test the ability of five 5-HT3 antagonist
Xia Wen +2 more
exaly +4 more sources
Immunohistochemical localization of OCT2 in the cochlea of various species [PDF]
Laryngoscope, 2015 ObjectiveTo locate the organic cation transporter 2 (OCT2) in the cochlea of three different species and to modulate the ototoxicity of cisplatin in the guinea pig by pretreatment with phenformin, having a known affinity for OCT2.Study DesignImmunohistochemical and in vivo study.MethodsSections from the auditory end organs were subjected to ...
Hans Ehrsson +2 more
exaly +4 more sources
Lower Prevalence of the OCT2 Ser270 Allele in Patients with Essential Hypertension
Clinical and Experimental Hypertension, 2006 Impairment of the renal dopaminergic pathway has been shown to result in essential hypertension. The Organic Cation Transporter 2, OCT2 (SLC22A2), has been implicated in renal dopamine handling as well as in the inactivation of circulating catecholamines and is supposed to be involved in blood pressure regulation.
Andreas Lazar +2 more
exaly +4 more sources
Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes
Biochimica Et Biophysica Acta - Biomembranes, 1999 The molecular mechanisms of organic cation transport by rat OCT2 was examined in the Xenopus oocyte expression system. When extracellular Na+ ions were replaced with K+ ions, uptake of tetraethylammonium (TEA) by OCT2-expressing oocytes was decreased ...
Masahiro Okuda +2 more
exaly +2 more sources
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Oct2 transcription factors in fish – a comparative genomic analysis
Fish and Shellfish Immunology, 2006The Oct2 transcription factor is important in driving expression of the IgH locus of the channel catfish, Ictalurus punctatus. Two isoforms, catfish Oct2alpha and Oct2beta, have been characterized at the level of expression and function, but little is known of the structure of the Oct2 gene in catfish.
Melanie R Wilson +2 more
exaly +3 more sources
Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2
Nature Structural & Molecular Biology, 2023A wide range of endogenous and xenobiotic organic ions require facilitated transport systems to cross the plasma membrane for their disposition. In mammals, organic cation transporter (OCT) subtypes 1 and 2 (OCT1 and OCT2, also known as SLC22A1 and SLC22A2, respectively) are polyspecific transporters responsible for the uptake and clearance of ...
Yang Suo +7 more
openaire +2 more sources